Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jonathan B. Johnston"'
Autor:
Coral Y. Zhou, Caitlin I. Stoddard, Jonathan B. Johnston, Michael J. Trnka, Ignacia Echeverria, Eugene Palovcak, Andrej Sali, Alma L. Burlingame, Yifan Cheng, Geeta J. Narlikar
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2033-2044 (2017)
The hexameric AAA+ ATPases Rvb1 and Rvb2 (Rvbs) are essential for diverse processes ranging from metabolic signaling to chromatin remodeling, but their functions are unknown. While originally thought to act as helicases, recent proposals suggest that
Externí odkaz:
https://doaj.org/article/163ed11f9a7840cd8bc6609903d40b17
Autor:
Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 15-25 (2013)
Inhibition of the Trypanosoma cruzi cysteine protease cruzain has been proposed as a therapeutic approach for the treatment of Chagas’ disease. Among the best-studied cruzain inhibitors to date is the vinylsulfone K777 (1), which has proven effecti
Externí odkaz:
https://doaj.org/article/e62bfad262f447a899c4489a4219fb1f
Autor:
Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003588 (2015)
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate t
Externí odkaz:
https://doaj.org/article/58924484fcc34757ab91165c0f1e5fe2
Autor:
Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1736 (2012)
BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due
Externí odkaz:
https://doaj.org/article/0fedffa603054e8faa798a38e8ca4f82
Autor:
Luz Díaz-Storani, Jonathan B. Johnston, Andrea B. J. Bracca, Diego M. Moreno, Exequiel O. J. Porta, Anaelle A. Clary, María Sol Ballari, Guillermo R. Labadie
Publikováno v:
Bioorganic & Medicinal Chemistry. 44:116304
A series of C15-C20 isoprenyl derivatives bearing terminal alkenyl and alkynyl groups were synthesized as possible substrates of the methyl-branched lipid ω-hydroxylase CYP124A1 from Mycobacterium tuberculosis. The interactions of each compound with
Autor:
Caitlin I. Stoddard, Geeta J. Narlikar, Alma L. Burlingame, Jonathan B. Johnston, Andrej Sali, Michael J. Trnka, Eugene Palovcak, Yifan Cheng, Ignacia Echeverria, Coral Y. Zhou
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2033-2044 (2017)
Summary The hexameric AAA+ ATPases Rvb1 and Rvb2 (Rvbs) are essential for diverse processes ranging from metabolic signaling to chromatin remodeling, but their functions are unknown. While originally thought to act as helicases, recent proposals sugg
Autor:
Geeta J. Narlikar, David A. Agard, Alma L. Burlingame, Madeline M. Keenen, Jonathan B. Johnston, Adam G. Larson, Sy Redding, Michael J. Trnka, Daniel Elnatan
Publikováno v:
Nature, vol 547, iss 7662
Nature
Nature
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5a703edd466f86d93bfe3e22dd1890
https://escholarship.org/uc/item/3vh8n30c
https://escholarship.org/uc/item/3vh8n30c
Autor:
John Kim, Jessica A. Kirshner, Yan Xue, Jonathan B. Johnston, Steve E. Jacobsen, HyeongJun Kim, Nicita Mehta, Alma L. Burlingame, Somsakul Pop Wongpalee, Joseph J. Loparo, Linda Yen
Publikováno v:
Mol Cell
Summary Microrchidia (MORC) ATPases are critical for gene silencing and chromatin compaction in multiple eukaryotic systems, but the mechanisms by which MORC proteins act are poorly understood. Here, we apply a series of biochemical, single-molecule,
Autor:
Amander T. Clark, Dinshaw J. Patel, Jamie Ho, Jiamu Du, Jonathan B. Johnston, Steven E. Jacobsen, Wanlu Liu, Sisi Li, Alma L. Burlingame, William A. Pastor, Bryan Stender, Colin J. Shew, Linda Yen, Lucia Daxinger
Publikováno v:
Proceedings of the National Academy of Sciences, 113(35), E5108-E5116
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 35
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 35
Microrchidia (MORC) proteins are GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPases that function in gene regulation in multiple organisms. Animal MORCs also contain CW-type zinc finger domains, which are known to bind to modified h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c89e1212a9bbf9856b30f340b421277
https://hdl.handle.net/1887/88018
https://hdl.handle.net/1887/88018
Publikováno v:
Trends in Microbiology. 19:530-539
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects 10 million people worldwide and kills 2 million people every year. The uptake and utilization of nutrients by Mtb within the host cell is still poorly understood, although lip