Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Jonathan B. Chaires"'
Autor:
Gurudas Chakraborty, Konstantin Balinin, Rafael del Villar-Guerra, Meike Emondts, Giuseppe Portale, Mark Loznik, Wiebe Jacob Niels Klement, Lifei Zheng, Tanja Weil, Jonathan B. Chaires, Andreas Herrmann
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109689- (2024)
Summary: The distinct folding accompanied by its polymorphic character renders DNA G-quadruplexes promising biomolecular building blocks to construct novel DNA-based and supramolecular assemblies. However, the highly polar nature of DNA limits the us
Externí odkaz:
https://doaj.org/article/2c883cf09857438888b4da6e76e15e94
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified that exhibit selectivity for G4s over alternative forms of DNA, such as the ubiquitous dup
Externí odkaz:
https://doaj.org/article/222165cb4c8246be965eb0eccafe0b5a
Autor:
Lynn W DeLeeuw, Robert C Monsen, Vytautas Petrauskas, Robert D Gray, Lina Baranauskiene, Daumantas Matulis, John O Trent, Jonathan B Chaires
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245675 (2021)
The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end fusions. It is the only component of shelterin that binds single-stranded DNA. We describe h
Externí odkaz:
https://doaj.org/article/d54a95b20059451db626866be17532dd
Publikováno v:
Nucleic Acids Research. 51:1943-1959
Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d409dfd27b7ed4585cb38cf1dbb4cb8
https://doi.org/10.1093/nar/gkad014
https://doi.org/10.1093/nar/gkad014
Publikováno v:
Accounts of Chemical Research. 55:3242-3252
ConspectusG-quadruplexes (G4s) are distinctive four-stranded DNA or RNA structures found within cells that are thought to play functional roles in gene regulation and transcription, translation, recombination, and DNA damage/repair. While G4 structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d59aec458fa4302b2831a98ff83dbd
https://doi.org/10.1021/acs.accounts.2c00519
https://doi.org/10.1021/acs.accounts.2c00519
Autor:
Shesh N Rai, Sudhir Srivastava, Jianmin Pan, Xiaoyong Wu, Somesh P Rai, Chongkham S Mekmaysy, Lynn DeLeeuw, Jonathan B Chaires, Nichola C Garbett
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220765 (2019)
The thermoanalytical technique differential scanning calorimetry (DSC) has been applied to characterize protein denaturation patterns (thermograms) in blood plasma samples and relate these to a subject's health status. The analysis and classification
Externí odkaz:
https://doaj.org/article/9437ad295cf94d8faceac981575995d2
Autor:
Santi Mestre-Fos, Petar I Penev, John Colin Richards, William L Dean, Robert D Gray, Jonathan B Chaires, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226177 (2019)
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformation
Externí odkaz:
https://doaj.org/article/d9c87c731498483f8c555473ba91cdd0
Autor:
Robert C Monsen, Lynn W DeLeeuw, William L Dean, Robert D Gray, Srinivas Chakravarthy, Jesse B Hopkins, Jonathan B Chaires, John O Trent
Publikováno v:
Nucleic Acids Research. 50:4127-4147
We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach. Our approach uses quantitative biophysical tools (analytical ultracentrifugation, small-angle X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0957c5403c4afa49626d2a0a8e1f49
https://doi.org/10.1093/nar/gkac182
https://doi.org/10.1093/nar/gkac182
Autor:
Maryam Zahin, William L Dean, Shin-Je Ghim, Joongho Joh, Robert D Gray, Sujita Khanal, Gregory D Bossart, Antonio A Mignucci-Giannoni, Eric C Rouchka, Alfred B Jenson, John O Trent, Jonathan B Chaires, Julia H Chariker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195625 (2018)
The Florida manatee (Trichechus manatus latirotris) is a threatened aquatic mammal in United States coastal waters. Over the past decade, the appearance of papillomavirus-induced lesions and viral papillomatosis in manatees has been a concern for tho
Externí odkaz:
https://doaj.org/article/87735bf4c1f340e58a3c83c0df098c6e
Autor:
Nichola C Garbett, Guy N Brock, Jonathan B Chaires, Chongkham S Mekmaysy, Lynn DeLeeuw, Kathy L Sivils, John B Harley, Brad H Rovin, K B Kulasekera, Wael N Jarjour
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186398 (2017)
OBJECTIVE:Plasma thermograms (thermal stability profiles of blood plasma) are being utilized as a new diagnostic approach for clinical assessment. In this study, we investigated the ability of plasma thermograms to classify systemic lupus erythematos
Externí odkaz:
https://doaj.org/article/512a96db786e4dc7a14a6eedc10242d1