Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jonathan B Wagner"'
Autor:
Ronald Palmen, Tracy Sandritter, Lindsey Malloy-Walton, Christopher Follansbee, Jonathan B. Wagner
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Flecainide is a class IC antiarrhythmic utilized in prophylaxis of refractory paroxysmal supraventricular tachycardias in pediatric populations. Despite being a highly effective agent, its narrow therapeutic index increases the risk of toxicity and p
Externí odkaz:
https://doaj.org/article/da9f5df906fd4c07b981905f4c68fcdf
Autor:
Jonathan B. Wagner, Susan Abdel‐Rahman, Andrea Gaedigk, Roger Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, J. Steven Leeder
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 628-637 (2020)
This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8–21 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n = 13; 521CC, n = 2)
Externí odkaz:
https://doaj.org/article/9623a046028444f18b6d4117c07ea6a9
Autor:
Chance S. Friesen, Sherwin S. Chan, Jonathan B. Wagner, Chelsea Hosey‐Cojocari, Iván L. Csanaky, Valentina Shakhnovich
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 781-783 (2021)
Abstract Nonalcoholic fatty liver disease (NAFLD) affects up to 70% of children with obesity and has become the number one etiology for liver transplant in the United States. Early, effective intervention is critical to prevent disease progression in
Externí odkaz:
https://doaj.org/article/f61a6b7f86c440d8abb61605030e8b9e
Autor:
Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S. Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke R. Sweeney, Alec Friesen, Jason D. Fraser, Valentina Shakhnovich
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Obesity is the single greatest risk factor for nonalcoholic fatty liver disease (NAFLD). Without intervention, most pediatric patients with NAFLD continue to gain excessive weight, making early, effective weight loss intervention key for disease trea
Externí odkaz:
https://doaj.org/article/0d34bc7d196a472eb158eb3b5f6542fb
Publikováno v:
Advances in Molecular Pathology. 5:109-118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac276f614576c12be77a2da3c6aa438
https://doi.org/10.1016/j.yamp.2022.05.003
https://doi.org/10.1016/j.yamp.2022.05.003
Autor:
Laura B. Ramsey, Li Gong, Seung‐been Lee, Jonathan B. Wagner, Xujia Zhou, Katrin Sangkuhl, Solomon M. Adams, Robert J. Straka, Philip E. Empey, Erin C. Boone, Teri E. Klein, Mikko Niemi, Andrea Gaedigk
Publikováno v:
Clinical pharmacology and therapeutics.
The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variation within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ef3f17891eeacecb260e955975b37d
https://pubmed.ncbi.nlm.nih.gov/35797228
https://pubmed.ncbi.nlm.nih.gov/35797228
Autor:
Leon van Haandel, Andrea Gaedigk, Vincent S. Staggs, Geetha Raghuveer, Jonathan B. Wagner, J. Steven Leeder, Susan M. Abdel-Rahman, Roger Gaedigk
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 628-637 (2020)
Clinical and Translational Science
Clinical and Translational Science
This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-21 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n = 13; 521CC, n = 2) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea5456b533c4aa8dc15a8c8fe501d89
https://doaj.org/article/9623a046028444f18b6d4117c07ea6a9
https://doaj.org/article/9623a046028444f18b6d4117c07ea6a9
Autor:
R. Mark Payne, Gail D. Pearson, Andrew S. Mackie, Stephen M. Paridon, Amanda J. Shillingford, Stacy Woyciechowski, Shabana Shahanavaz, Christopher K. Davis, James L. Yeager, David J. Goldberg, Arash Sabati, Bryan H. Goldstein, Shaji C. Menon, Victor Zak, Ruchira Garg, Benjamin P. Frischhertz, Matthew D. Files, Jeffrey P. Jacobs, Michael DiMaria, Jonathan Rhodes, Seong Ho Kim, Anji T. Yetman, Mario Stylianou, Michelle S Hamstra, Kevin D. Hill, Marc E. Richmond, Victoria L. Pemberton, Anitha S. John, Kathleen A. Rathge, Christopher J. Petit, Jonathan B Wagner, Salil Ginde, Brian W. McCrindle, Mark W. Russell, Michael G. McBride, Todd T. Nowlen, Kurt R. Schumacher, Elaine M. Urbina, Kimberly E. McHugh, Daniel J. Penny, Gi Beom Kim, Peter C. Frommelt
Publikováno v:
Circulation. 141:641-651
Background: The Fontan operation creates a total cavopulmonary connection, a circulation in which the importance of pulmonary vascular resistance is magnified. Over time, this circulation leads to deterioration of cardiovascular efficiency associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098f79b92fa377485b0581c6578c1279
https://doi.org/10.1161/circulationaha.119.044352
https://doi.org/10.1161/circulationaha.119.044352
Autor:
Chelsea Hosey-Cojocari, Chance S. Friesen, Valentina Shakhnovich, Jonathan B. Wagner, Iván L. Csanaky, Sherwin S Chan
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 781-783 (2021)
Clinical and Translational Science
Clinical and Translational Science
Nonalcoholic fatty liver disease (NAFLD) affects up to 70% of children with obesity and has become the number one etiology for liver transplant in the United States. Early, effective intervention is critical to prevent disease progression into adulth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f76199412631b66b6fe28e8b9804501
https://doi.org/10.1111/cts.12952
https://doi.org/10.1111/cts.12952
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699bc3230303aacd3a9c86415f651c74
http://europepmc.org/articles/PMC6697721
http://europepmc.org/articles/PMC6697721