Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Jonathan B Demb"'
Autor:
Hyoseo Lee, Hannah Weinberg-Wolf, Hae-Lim Lee, Tracy Lee, Joseph Conte, Carlos Godoy-Parejo, Jonathan B Demb, Andrii Rudenko, In-Jung Kim
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002386 (2023)
Defensive responses to visually threatening stimuli represent an essential fear-related survival instinct, widely detected across species. The neural circuitry mediating visually triggered defensive responses has been delineated in the midbrain. Howe
Externí odkaz:
https://doaj.org/article/88f34a30d36243718a29e1afa91ba1a2
Autor:
Silvia JH Park, Evan E Lieberman, Jiang-Bin Ke, Nao Rho, Padideh Ghorbani, Pouyan Rahmani, Na Young Jun, Hae-Lim Lee, In-Jung Kim, Kevin L Briggman, Jonathan B Demb, Joshua H Singer
Publikováno v:
eLife, Vol 9 (2020)
Night vision in mammals depends fundamentally on rod photoreceptors and the well-studied rod bipolar (RB) cell pathway. The central neuron in this pathway, the AII amacrine cell (AC), exhibits a spatially tuned receptive field, composed of an excitat
Externí odkaz:
https://doaj.org/article/1a1dcc80608b452db3fc0bfe5ad86051
Publikováno v:
eLife, Vol 5 (2016)
Visual processing depends on specific computations implemented by complex neural circuits. Here, we present a circuit-inspired model of retinal ganglion cell computation, targeted to explain their temporal dynamics and adaptation to contrast. To loca
Externí odkaz:
https://doaj.org/article/a268cf598cac473a88943ada7e61ce01
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
A presynaptic neuron can increase its computational capacity by transmitting functionally distinct signals to each of its postsynaptic cell types. To determine whether such computational specialization occurs over fine spatial scales within a neurite
Externí odkaz:
https://doaj.org/article/ae68a466094444d1adc26ee2c3475501
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Direction selectivity represents an elementary sensory computation that can be related to underlying synaptic mechanisms. In mammalian retina, direction-selective ganglion cells (DSGCs) respond strongly to visual motion in a “preferred” direction
Externí odkaz:
https://doaj.org/article/c91f8581878d41c89e3a8c0e66c4b5a9
Autor:
Lena S. Mortensen, Silvia J.H. Park, Jiang-bin Ke, Benjamin H. Cooper, Lei Zhang, Cordelia Imig, Siegrid Löwel, Kerstin Reim, Nils Brose, Jonathan B. Demb, Jeong-Seop Rhee, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2239-2250 (2016)
Complexin (Cplx) proteins modulate the core SNARE complex to regulate exocytosis. To understand the contributions of Cplx to signaling in a well-characterized neural circuit, we investigated how Cplx3, a retina-specific paralog, shapes transmission a
Externí odkaz:
https://doaj.org/article/3c96857817d840289321a4eb85904210
Autor:
Kathy Zhang, Pouyan Rahmani, Nicholas J. Justice, Hannah Walsh, Jonathan B. Demb, Joseph Pottackal
Publikováno v:
J Neurosci
Intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit melanopsin-dependent light responses that persist in the absence of rod and cone photoreceptor-mediated input. In addition to signaling anterogradely to the brain, ipRGCs signal ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa48783bde85c27a03958081d001054
https://doi.org/10.1523/jneurosci.0674-20.2020
https://doi.org/10.1523/jneurosci.0674-20.2020
Autor:
Earnest P. Chen, Yonejung Yoon, Ethan J. Mohns, Christopher Starr, Wei Liu, Louis R. Pasquale, Yidong Li, Jonathan B. Demb, Michael C. Crair, Xinzheng Guo, Jing Zhou, Kohichi Tanaka, Hongbing Wang, Bo Chen, Christopher P. Kellner
Publikováno v:
Cell
Summary Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information from the retina to the brain. Diverse insults and pathological states cause degeneration of RGC somas and axons leading to irreversible vision loss. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64766fa266b2f36c892a54448afa3b2c
https://pubmed.ncbi.nlm.nih.gov/34381202
https://pubmed.ncbi.nlm.nih.gov/34381202
Autor:
Jiang-Bin Ke, Pouyan Rahmani, Evan E. Lieberman, Kevin L. Briggman, Joshua H. Singer, Na Young Jun, In-Jung Kim, Nao Rho, Hae-Jim Lee, Silvia J. H. Park, Jonathan B. Demb, Padideh Ghorbani
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Night vision in mammals depends fundamentally on rod photoreceptors and the well-studied rod bipolar (RB) cell pathway. The central neuron in this pathway, the AII amacrine cell (AC), exhibits a spatially tuned receptive field, composed of an excitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a21d7c5f2da2106b5202d46783c7c5
https://doi.org/10.1101/2020.02.24.963868
https://doi.org/10.1101/2020.02.24.963868
Autor:
Pouyan Rahmani, In-Jung Kim, Jiang-Bin Ke, Joseph Pottackal, Na Young Jun, Joshua H. Singer, Jonathan B. Demb, Silvia J. H. Park
Publikováno v:
The Journal of Neuroscience. 38:3753-3766
Inhibitory interneurons sculpt the outputs of excitatory circuits to expand the dynamic range of information processing. In mammalian retina, >30 types of amacrine cells provide lateral inhibition to vertical, excitatory bipolar cell circuits, but fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4b059d550d543c958a59050d0eaf54
https://doi.org/10.1523/jneurosci.2518-17.2018
https://doi.org/10.1523/jneurosci.2518-17.2018