Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonathan B Coulter"'
Autor:
Jonathan B Coulter, Hariharan Easwaran
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002081 (2023)
Development of resistance in castration-resistant prostate cancer (CRPC) involves epigenetic pathways. A new study in PLOS Biology demonstrates that combined therapy targeting enhancer of zeste homolog 2 (EZH2) and histone deacetylases (HDACs) may se
Externí odkaz:
https://doaj.org/article/613dcf62225e4a31a73fa8a911c2ab2c
Autor:
Hernando Lopez-Bertoni, Amanda Johnson, Yuan Rui, Bachchu Lal, Sophie Sall, Maureen Malloy, Jonathan B. Coulter, Maria Lugo-Fagundo, Sweta Shudir, Harmon Khela, Christopher Caputo, Jordan J. Green, John Laterra
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Altered patterns of 5hmC and 5mC are widely
Externí odkaz:
https://doaj.org/article/c6cf026f792b49c69fedffbfcee29718
Autor:
Arlene L. Oei, Preethi Korangath, Kathleen Mulka, Mikko Helenius, Jonathan B. Coulter, Jacqueline Stewart, Esteban Velarde, Johannes Crezee, Brian Simons, Lukas J. A. Stalpers, H. Petra Kok, Kathleen Gabrielson, Nicolaas A. P. Franken, Robert Ivkov
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 0, Pp 47-63 (2019)
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and
Externí odkaz:
https://doaj.org/article/373ac4be0e8649e7bbb04b8ecf130b94
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Figure from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74e0f528f0b44e595a4a686d003dd6
https://doi.org/10.1158/1541-7786.22528140
https://doi.org/10.1158/1541-7786.22528140
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Data from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079fa3355e6e7a7e7440b04c149268c2
https://doi.org/10.1158/1541-7786.22528146
https://doi.org/10.1158/1541-7786.22528146
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
A limited number of cell lines have fueled the majority of preclinical prostate cancer research, but their genomes remain incompletely characterized. Here, we utilized whole-genome linked-read sequencing for comprehensive characterization of phased m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b27371dbf32222e2f7eb6c3686846b7
https://doi.org/10.1158/1541-7786.c.6545628.v1
https://doi.org/10.1158/1541-7786.c.6545628.v1
Autor:
Theodore L. DeWeese, Srinivasan Yegnasubramanian, William G. Nelson, Russell Hales, Aileen Santos, John T. Isaacs, Susan Dalrymple, Nina Razavi, Emma J. Knight, Omar Mian, Haoming Zhou, Yonggang Zhang, Raju R. Raval, Jonathan B. Coulter, Michael C. Haffner, Mohammad Hedayati
IR reduced xenograft growth in intact mice without androgen modulation. Xenograft tumors of LAPC4 (A) and LNCaP (B) cells established in intact nude mice were exposed to sham (control) or 8Gy ionizing radiation (IR). Tumor size was longitudinally det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148f96aab6fef6cf7e8b089de59b2a93
https://doi.org/10.1158/1078-0432.22456479
https://doi.org/10.1158/1078-0432.22456479
Autor:
Theodore L. DeWeese, Srinivasan Yegnasubramanian, William G. Nelson, Russell Hales, Aileen Santos, John T. Isaacs, Susan Dalrymple, Nina Razavi, Emma J. Knight, Omar Mian, Haoming Zhou, Yonggang Zhang, Raju R. Raval, Jonathan B. Coulter, Michael C. Haffner, Mohammad Hedayati
Purpose: The current standard of care for patients with locally advanced prostate cancer is a combination of androgen deprivation and radiation therapy. Radiation is typically given with androgen suppression when testosterone levels are at their nadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066ed94a28b4e3359669b1d517be798f
https://doi.org/10.1158/1078-0432.c.6523323
https://doi.org/10.1158/1078-0432.c.6523323
Autor:
Theodore L. DeWeese, Srinivasan Yegnasubramanian, William G. Nelson, Russell Hales, Aileen Santos, John T. Isaacs, Susan Dalrymple, Nina Razavi, Emma J. Knight, Omar Mian, Haoming Zhou, Yonggang Zhang, Raju R. Raval, Jonathan B. Coulter, Michael C. Haffner, Mohammad Hedayati
Clonogenic survival of PC3 cells following IR and DHT treatments. Clonogenic survival fraction is shown for AR negative PC3 cells exposed to vehicle control, 100 nM DHT, 4 Gy of IR or the combination of both. NS, not significant.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361ce8fc2496743fa12232a977d15a7e
https://doi.org/10.1158/1078-0432.22456482
https://doi.org/10.1158/1078-0432.22456482
Autor:
Theodore L. DeWeese, Srinivasan Yegnasubramanian, William G. Nelson, Russell Hales, Aileen Santos, John T. Isaacs, Susan Dalrymple, Nina Razavi, Emma J. Knight, Omar Mian, Haoming Zhou, Yonggang Zhang, Raju R. Raval, Jonathan B. Coulter, Michael C. Haffner, Mohammad Hedayati
DNA repair genes following androgen stimulation. Androgen-deprived LNCaP cells were exposed to vehicle or 100nM DHT for the indicated times and mRNA of classical AR-regulated genes (A) or DNA repair-related genes (B) were measured using qRT-PCR. mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346888b97c3f45c1bc7069dcd47cee10
https://doi.org/10.1158/1078-0432.22456488.v1
https://doi.org/10.1158/1078-0432.22456488.v1