Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Jonathan B Chaires"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270165 (2022)
DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified that exhibit selectivity for G4s over alternative forms of DNA, such as the ubiquitous dup
Externí odkaz:
https://doaj.org/article/69041d37cfcd4e85ac7eacdc4d385475
Autor:
Lynn W DeLeeuw, Robert C Monsen, Vytautas Petrauskas, Robert D Gray, Lina Baranauskiene, Daumantas Matulis, John O Trent, Jonathan B Chaires
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245675 (2021)
The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end fusions. It is the only component of shelterin that binds single-stranded DNA. We describe h
Externí odkaz:
https://doaj.org/article/d54a95b20059451db626866be17532dd
Autor:
Shesh N Rai, Sudhir Srivastava, Jianmin Pan, Xiaoyong Wu, Somesh P Rai, Chongkham S Mekmaysy, Lynn DeLeeuw, Jonathan B Chaires, Nichola C Garbett
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220765 (2019)
The thermoanalytical technique differential scanning calorimetry (DSC) has been applied to characterize protein denaturation patterns (thermograms) in blood plasma samples and relate these to a subject's health status. The analysis and classification
Externí odkaz:
https://doaj.org/article/9437ad295cf94d8faceac981575995d2
Autor:
Santi Mestre-Fos, Petar I Penev, John Colin Richards, William L Dean, Robert D Gray, Jonathan B Chaires, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226177 (2019)
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformation
Externí odkaz:
https://doaj.org/article/d9c87c731498483f8c555473ba91cdd0
Autor:
Maryam Zahin, William L Dean, Shin-Je Ghim, Joongho Joh, Robert D Gray, Sujita Khanal, Gregory D Bossart, Antonio A Mignucci-Giannoni, Eric C Rouchka, Alfred B Jenson, John O Trent, Jonathan B Chaires, Julia H Chariker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195625 (2018)
The Florida manatee (Trichechus manatus latirotris) is a threatened aquatic mammal in United States coastal waters. Over the past decade, the appearance of papillomavirus-induced lesions and viral papillomatosis in manatees has been a concern for tho
Externí odkaz:
https://doaj.org/article/87735bf4c1f340e58a3c83c0df098c6e
Autor:
Nichola C Garbett, Guy N Brock, Jonathan B Chaires, Chongkham S Mekmaysy, Lynn DeLeeuw, Kathy L Sivils, John B Harley, Brad H Rovin, K B Kulasekera, Wael N Jarjour
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186398 (2017)
OBJECTIVE:Plasma thermograms (thermal stability profiles of blood plasma) are being utilized as a new diagnostic approach for clinical assessment. In this study, we investigated the ability of plasma thermograms to classify systemic lupus erythematos
Externí odkaz:
https://doaj.org/article/512a96db786e4dc7a14a6eedc10242d1
Autor:
Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126420 (2015)
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o
Externí odkaz:
https://doaj.org/article/3bd91e8f42734f39965350067490e003
Autor:
Nichola C Garbett, Michael L Merchant, C William Helm, Alfred B Jenson, Jon B Klein, Jonathan B Chaires
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84710 (2014)
Improved methods for the accurate identification of both the presence and severity of cervical intraepithelial neoplasia (CIN) and extent of spread of invasive carcinomas of the cervix (IC) are needed. Differential scanning calorimetry (DSC) has rece
Externí odkaz:
https://doaj.org/article/09cf011b9a9d40928773b730e7dea6fe
Autor:
Jonathan B Chaires, John O Trent, Robert D Gray, William L Dean, Robert Buscaglia, Shelia D Thomas, Donald M Miller
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115580 (2014)
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the h
Externí odkaz:
https://doaj.org/article/4b8ffa132fa7426e88368c69a7a664b2
Autor:
Gurudas Chakraborty, Konstantin Balinin, Rafael del Villar-Guerra, Meike Emondts, Giuseppe Portale, Mark Loznik, Wiebe Jacob Niels Klement, Lifei Zheng, Tanja Weil, Jonathan B. Chaires, Andreas Herrmann
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109689- (2024)
Summary: The distinct folding accompanied by its polymorphic character renders DNA G-quadruplexes promising biomolecular building blocks to construct novel DNA-based and supramolecular assemblies. However, the highly polar nature of DNA limits the us
Externí odkaz:
https://doaj.org/article/2c883cf09857438888b4da6e76e15e94