Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Autor: Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report tha

Externí odkaz: https://doaj.org/article/f8f3d49491b44be689810b9c6842639c

Ceramide-induced BOK promotes mitochondrial fission in preeclampsia

Autor: Isabella Caniggia, Abby Farrell, Jonathan Ausman, Andrea Tagliaferro, Joelcio Francisco Abbade, Martin Post, Leonardo Ermini

Publikováno v: Cell Death and Disease, Vol 9, Iss 3, Pp 1-18 (2018)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Cell Death & Disease

Made available in DSpace on 2018-12-11T17:18:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 National Institutes of Health Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb43093b4ce64961bbdd8841d065f5af
http://hdl.handle.net/11365/1095267

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

Autor: Michael L. Litvack, Behzad Yeganeh, Megan Melland-Smith, Jonathan Ausman, Michelle Letarte, Isabella Caniggia, Alessandro Rolfo, Leonardo Ermini, Tullia Todros, Martin Post

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports

Preeclampsia (PE), an hypertensive disorder of pregnancy, exhibits increased circulating levels of a short form of the auxillary TGF-beta (TGFB) receptor endoglin (sENG). Until now, its release and functionality in PE remains poorly understood. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aeb36b67c427ce8f850db4168a7fce
https://doi.org/10.1038/s41598-017-12491-4

Social Factors Influencing Career Choice in a Medical School in the United Arab Emirates

Autor: Anas Javed, Abdolraoof Salehi Pour, Rizwana B Shaikh, Shuja Ahmed, Jayadevan Sreedharan, Shatha Al-Sharbatti, Elsheba Mathew, Mohammad Abdul Samad, Jonathan Ausman

Publikováno v: Education in Medicine Journal. 5

Objective : The goal of this research was to identify familial and non-familial social factors influencing post-secondary students’ choices of career in medicine. Method : The comparative study was conducted in Ajman, among medical students in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61079a2bd739e5e95ba204fc46db41d0
https://doi.org/10.5959/eimj.v5i1.16