Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan Almaden"'
Publikováno v:
Molecular Cancer Therapeutics. 20:LBA011-LBA011
CRISPR/Cas9 functional genetic screens are a powerful tool to discover drug targets in cancer. While many screens have been performed for identification of intrinsic cancer vulnerabilities, synthetic lethalities of targeted therapies remain largely u
Autor:
Xinmeng Jasmine Mu, Meirong Xu, Shahram Salek-Ardakani, Cinthia Costa-Jones, Lisa Nguyen, James Solowiej, David Looper, Scott L. Weinrich, Robert Louis Hoffman, Sutton Scott Channing, Sacha Ninkovic, Kephart Susan Elizabeth, Sherry Niessen, John Chionis, Jadwiga Bienkowska, Kevin Daniel Freeman-Cook, Rose Ann Ferre, John Lapek, Cecilia Oderup, Jordan Carelli, Cathy Zhang, Nanni Huser, Elizabeth A. McMillan, Asako Nagata, Martha A. Ornelas, Brion W. Murray, Douglas Carl Behenna, Koleen Eisele, Todd VanArsdale, Zhou Zhu, Zhengyan Kan, Chaoting Liu, Nichol Miller, Zehnder Luke Raymond, Michael A. White, Ying Ding, Nathan V. Lee, Jonathan Almaden, Qin Zhang, Tran Khanh Tuan, Ping Wei, Stephen Dann, Britton Boras, Tim S. Wang, Ravi Visswanathan, You-Ai He, Michele McTigue, Elizabeth Wilson
Publikováno v:
Cancer Cell. 39:1404-1421.e11
Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to discover PAL resistance mechanisms in preclinical models and through analys
Autor:
Elizabeth A. McMillan, Koleen Eisele, Christina Adams, John Chionis, Timothy Affolter, Nichol Miller, Monica Ramstetter, Christopher P. Dillon, Jonathan Almaden, Lynn Wang, Tim S. Wang, Stephen Dann, Todd VanArsdale, Smitha Pillai
Publikováno v:
Cancer Research. 81:2960-2960
Overcoming checkpoints to cell cycle control is the basis for tumorigenesis and malignant growth. Therefore, models that recapitulate clinically relevant cell cycle deregulation enhance our understanding of defined tumors subsets. Specifically, pancr
B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel
Autor:
Yi Liu, Jeremy Davis-Turak, Masataka Asagiri, Ananda W. Goldrath, Dennis C. Otero, Michael David, Alexander Hoffmann, Jonathan Almaden, Harry Birnbaum, Edward Yang
Publikováno v:
Blood. 127:1276-1286
Targeted deletion of BAFF causes severe deficiency of splenic B cells. BAFF-R is commonly thought to signal to nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB)-inducing kinase dependent noncanonical NF-κB RelB. However, RelB-defi
Autor:
Jeremy Davis-Turak, Alexander Hoffmann, Jesse D. Vargas, Maxim N. Shokhirev, Jonathan Almaden, Harry Birnbaum, Theresa M Russell
Publikováno v:
Molecular Systems Biology
Molecular systems biology, vol 11, iss 1
Molecular systems biology, vol 11, iss 1
Understanding the functions of multi-cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype. B-lymphocyte population dynamics, which are predictive of immune response a
Autor:
Dennis C. Otero, Kim A. Ngo, Yi Liu, Jeremy Davis-Turak, Soumen Basak, Harry Birnbaum, Rachel Tsui, Robert C. Rickert, Jonathan Almaden, Maxim N. Shokhirev, Alexander Hoffmann
Publikováno v:
Cell reports, vol 9, iss 6
Cell reports
Cell Reports, Vol 9, Iss 6, Pp 2098-2111 (2014)
Cell reports
Cell Reports, Vol 9, Iss 6, Pp 2098-2111 (2014)
SUMMARY BAFF, an activator of the noncanonical NFκB pathway, provides critical survival signals during B cell maturation and contributes to B cell proliferation. We found that the NFκB family member RelB is required ex vivo for B cell maturation, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad97ecdecf2ca810d199aefe25b45ba5
https://escholarship.org/uc/item/9dw7d9x7
https://escholarship.org/uc/item/9dw7d9x7
Publikováno v:
Metabolic Engineering. 7:38-44
In this paper, we described the optimization of a generic binding assay to measure ligand–receptor interactions for peroxisome proliferator-activated receptors (PPARs). The assay is based on scintillation proximity assay, in which a protein is coat
Autor:
Harry Birnbaum, Rachel Tsui, Julia Ponomarenko, Alexander Hoffmann, Jeremy Davis-Turak, Bryce N. Alves, Jessica K Fujimoto, Maxim N. Shokhirev, Jonathan Almaden
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(7)
The transcription factor NF-κB is a regulator of inflammatory and adaptive immune responses, yet only IκBα was shown to limit NF-κB activation and inflammatory responses. We investigated another negative feedback regulator, IκBε, in the regulat
Publikováno v:
Biochemistry. 47(17)
Small molecule activators of glucokinase (GK) were used in kinetic and equilibrium binding studies to probe the biochemical basis for their allosteric effects. These small molecules decreased the glucose K 0.5 ( approximately 1 mM vs approximately 8