Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jonathan A. Deane"'
Autor:
Jonathan A. Deane, Stuart Hawtin, Roland Feifel, Pius Loetscher, Sarah Limonta, Tobias Junt, Ralf Glatthar, Michellys Pierre-Yves, Marjorie Bourrel, Thomas Knoepfel, Cedric Bernard Andre, Thomas Boulay, Pierre Nimsgern, Sebastien Jacquier, Eric Vangrevelinghe, Michael Faller, Claudia Betschart, Jutta Blank, Phillip B. Alper, Geraldine Collignon Zipfel, Dirk Behnke
Publikováno v:
Journal of Medicinal Chemistry. 63:8276-8295
Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a6d30a18c77cefd130b9738cd75108
https://doi.org/10.1021/acs.jmedchem.0c00130
https://doi.org/10.1021/acs.jmedchem.0c00130
Autor:
Tao Jiang, Stuart Hawtin, Claudia Betschart, Tobias Junt, Pierre-Yves Michellys, Maureen Ibanez, Satoru Niwa, Jillian Maginnis, Zhang Yi, Geraldine Collignon Zipfel, James S. Rush, Wendy Richmond, Daniel Mutnick, Perry Gordon, Bishnu P. Nayak, David Buffet, Xue-Feng Zhu, Bo Liu, Thomas Knoepfel, Phil B. Alper, Una McKeever, Jonathan A. Deane, Syka Peter, Janice Hampton
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Antagonism of the Toll-like receptors (TLRs) 7 and TLR8 has been hypothesized to be beneficial to patients suffering from autoimmune conditions. A phenotypic screen for small molecule antagonists of TLR7/8 was carried out in a murine P4H1 cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec134d2986300d8633e09dd727ca587
https://pubmed.ncbi.nlm.nih.gov/32738975
https://pubmed.ncbi.nlm.nih.gov/32738975
Autor:
Martha Leibbrandt, Tamar Tomassian, Michael P. Cooke, Jonathan A. Deane, Tami Annable, Siddhartha Jain
Publikováno v:
Autoimmunity. 48:29-39
Subunit vaccines are typically poorly immunogenic when administered alone, and require adjuvants for robust responses. Triggering TLRs to boost antigen-specific adaptive immunity is an attractive approach to increase the potency and quality of vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee64fc7b7e4ed80d4142c44e035194b7
https://doi.org/10.3109/08916934.2014.959166
https://doi.org/10.3109/08916934.2014.959166
Autor:
Jonathan A. Deane, Jean S. Oak, Thomas E. Lane, Travis I. Moore, Linda N. Stiles, Lewis C. Cantley, Ji Luo, Michael G. Kharas, Hong Ji, David A. Fruman, Christian Rommel
Publikováno v:
Blood
The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea68c3392fcece1b849599777d91d45
https://doi.org/10.1182/blood-2006-07-038620
https://doi.org/10.1182/blood-2006-07-038620
Autor:
Lewis C. Cantley, David A. Fruman, Thomas E. Lane, Michael G. Kharas, Ji Luo, Jean S. Oak, Jonathan A. Deane
Publikováno v:
Proceedings of the National Academy of Sciences. 103:16882-16887
Sjögren's syndrome (SS) is an autoimmune disease that is characterized by infiltration of exocrine tissues, resulting in xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Here, we show that mice with T cell-specific loss of class IA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abccb8fa9d921576e776466d3f278975
https://doi.org/10.1073/pnas.0607984103
https://doi.org/10.1073/pnas.0607984103
Autor:
Jonathan A. Deane, David A. Fruman, Owen N. Witte, Michael G. Kharas, Naomi Rosenberg, Karen R O'Bosky, Stephane Wong
Publikováno v:
Blood. 103:4268-4275
BCR-ABL and v-ABL are oncogenic forms of the Abl tyrosine kinase that can cause leukemias in mice and humans. ABL oncogenes trigger multiple signaling pathways whose contribution to transformation varies among cell types. Activation of phosphoinositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c981b488f597695a5b3b6a20d58a432
https://doi.org/10.1182/blood-2003-07-2193
https://doi.org/10.1182/blood-2003-07-2193
Autor:
Jonathan A. Deane, David A. Fruman
Publikováno v:
Annual Review of Immunology. 22:563-598
▪ Abstract Cells of the immune system carry out diverse functions that are controlled by surface receptors for antigen, costimulatory molecules, cytokines, chemokines, and other ligands. A shared feature of signal transduction downstream of most re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddccdc11753ab3304d53623e07a59517
https://doi.org/10.1146/annurev.immunol.22.012703.104721
https://doi.org/10.1146/annurev.immunol.22.012703.104721
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 188(3)
Type I IFNs (IFN-I) are normally produced during antiviral responses, yet high levels of chronic IFN-I expression correlate with autoimmune disease. A variety of viral sensors generate IFN-I in their response, but other than TLRs, it is not fully kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef41059bc146da2b752c532e0044184b
https://pubmed.ncbi.nlm.nih.gov/22205024
https://pubmed.ncbi.nlm.nih.gov/22205024
Publikováno v:
Autoimmunity. 42(5)
Phosphoinositide kinase (PI3K) is activated by various receptors on lymphocytes and regulates development, activation, and tolerance. Genetic ablation of PI3K function in T cells leads to the appearance of autoimmune disorders. In B cells, loss of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e93c7a3eaa35751d649c0d8a5fcbb4
https://pubmed.ncbi.nlm.nih.gov/19811262
https://pubmed.ncbi.nlm.nih.gov/19811262
