Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jonathan A. Coulter"'
Autor:
Jie Feng, Varun Pathak, Niall M. Byrne, Tongchuan Wang, Cancan Yin, Reinhold J. Medina, Jonathan A. Coulter
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Background Radiotherapy is a major therapeutic modality for locally advanced head and neck cancer. However, the effectiveness of radiotherapy is hindered by resistance mechanisms, most notably hypoxia, leading to unfavourable treatment outco
Externí odkaz:
https://doaj.org/article/6ec043eac81e45ccacb1ebbd44bfc35c
Autor:
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency. This work examines the potential of RALA,
Externí odkaz:
https://doaj.org/article/7e5641acdb7d44ffa88ca6b2e0d590dd
Autor:
Jeremy M. C. Brown, Gerard G. Hanna, Nathanael Lampe, Balder Villagomez-Bernabe, James R. Nicol, Jonathan A. Coulter, Fred J. Currell
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast ca
Externí odkaz:
https://doaj.org/article/dc8bcf0877f34e35a7fc746e9975d94b
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-20 (2018)
Abstract Nanoparticles can be used as drug carriers, contrast agents and radiosensitisers for the treatment of cancer. Nanoparticles can either passively accumulate within tumour sites, or be conjugated with targeting ligands to actively enable tumou
Externí odkaz:
https://doaj.org/article/be3ca87f903a40089201aede25e00d4e
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or
Externí odkaz:
https://doaj.org/article/9ed2bf465afb41bba08a79b15b46f23a
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 249-258 (2017)
This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector,
Externí odkaz:
https://doaj.org/article/6e5a1d3407dd4a3ab97c5e21c1d9b806
Autor:
Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin
Publikováno v:
Journal of Functional Biomaterials, Vol 10, Iss 4, p 45 (2019)
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug. One of the most studied enzyme−prodrug combinations is the nitrore
Externí odkaz:
https://doaj.org/article/77539480b80f4442b6ffc59177ae4c97
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Figure from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74e0f528f0b44e595a4a686d003dd6
https://doi.org/10.1158/1541-7786.22528140
https://doi.org/10.1158/1541-7786.22528140
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Data from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079fa3355e6e7a7e7440b04c149268c2
https://doi.org/10.1158/1541-7786.22528146
https://doi.org/10.1158/1541-7786.22528146
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
A limited number of cell lines have fueled the majority of preclinical prostate cancer research, but their genomes remain incompletely characterized. Here, we utilized whole-genome linked-read sequencing for comprehensive characterization of phased m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b27371dbf32222e2f7eb6c3686846b7
https://doi.org/10.1158/1541-7786.c.6545628.v1
https://doi.org/10.1158/1541-7786.c.6545628.v1