Zobrazeno 1 - 10
of 1 407
pro vyhledávání: '"Jonathan A. Cooper"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Overexpression or activation of oncogenes or loss of tumor-suppressor genes can induce cellular senescence as a defense mechanism against tumor development, thereby maintaining cellular homeostasis. However, cancer cells can circumvent this
Externí odkaz:
https://doaj.org/article/56fbeca6658f458ab0ef871f85a4091e
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 3, Pp 233-243 (2018)
Cross talk of stromal-epithelial cells plays an essential role in both normal development and tumor initiation and progression. Fibroblast growth factor (FGF)-FGF receptor (FGFR)-Src kinase axis is one of the major signal transduction pathways to med
Externí odkaz:
https://doaj.org/article/764697e624b14f539739e537ef4d9929
Autor:
Yewande Pearse, Don Clarke, Shih-hsin Kan, Steven Q. Le, Valentina Sanghez, Anna Luzzi, Ivy Pham, Lina R. Nih, Jonathan D. Cooper, Patricia I. Dickson, Michelina Iacovino
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 452-463 (2022)
Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB) is a recessive genetic disorder that severely affects the brain due to a deficiency in the enzyme α-N-acetylglucosaminidase (NAGLU), leading to intra-lysosomal accumulation of partially de
Externí odkaz:
https://doaj.org/article/776a0875754d4cc8976309f509235d55
Autor:
Joshua T. Dearborn, Hemanth R. Nelvagal, Nicholas R. Rensing, Keigo Takahashi, Stephanie M. Hughes, Thomas M. Wishart, Jonathan D. Cooper, Michael Wong, Mark S. Sands
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have immunomodulatory, neuroprotective, and anti-seizure effects. Here, we determined the effects of chronic CBD administration in a mouse model of CLN1 diseas
Externí odkaz:
https://doaj.org/article/350eddea052f435687b37a8c0940ae75
Autor:
Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O’Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, Q. Paula Lei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a post-translational modification, was known to play a key role for antibody b
Externí odkaz:
https://doaj.org/article/92e48070fe3244d88988a4135f9f4025
Autor:
Yang Liu, Filipe Pinto, Xinyi Wan, Zhugen Yang, Shuguang Peng, Mengxi Li, Jonathan M. Cooper, Zhen Xie, Christopher E. French, Baojun Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In type II CRISPR systems, the guide RNA (gRNA) comprises a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA), both being essential in guided DNA targeting functions. Here the authors investigate the programmability of crRNA-trac
Externí odkaz:
https://doaj.org/article/1f2bda1d331e414c93297c37542d8e4a
Autor:
Gaolian Xu, Julien Reboud, Yunfei Guo, Hao Yang, Hongchen Gu, Chunhai Fan, Xiaohua Qian, Jonathan M. Cooper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Detecting nucleic acids often requires choosing between different amplification mechanisms. Here the authors present a generalisable and programmable isothermal methodology, demonstrated in clinical applications, including for multiplexed detection o
Externí odkaz:
https://doaj.org/article/0331783ada1f4cb7b18af55056fa9ac1
Autor:
Jonathan A. Cooper
Cooper answers two questions: why do police precincts look similar, despite being situated in very different environments? And, why do police engage in behavior that does not result in crime control? These two questions are closely related.
Autor:
Weronika Witkowska McConnell, Chris Davis, Suleman R. Sabir, Alice Garrett, Amanda Bradley-Stewart, Pawel Jajesniak, Julien Reboud, Gaolian Xu, Zhugen Yang, Rory Gunson, Emma C. Thomson, Jonathan M. Cooper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Current HCV nucleic acid-based diagnosis is largely performed in centralised laboratories. Here, the authors present a pan-genotypic RNA assay, based on reverse transcriptase loop mediated isothermal amplification and develop a low-cost prototype pap
Externí odkaz:
https://doaj.org/article/70d48ed159ba44c5ab33a8ce3a115976
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundThe Neuronal Ceroid Lipofuscinoses (NCLs) may be considered distinct neurodegenerative disorders with separate underlying molecular causes resulting from monogenetic mutations. An alternative hypothesis is to consider the NCLs as related di
Externí odkaz:
https://doaj.org/article/b51ea8ec992b4db487b873b02a349e16