Zobrazeno 1 - 10
of 2 432
pro vyhledávání: '"Jonathan A. Cooper"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Overexpression or activation of oncogenes or loss of tumor-suppressor genes can induce cellular senescence as a defense mechanism against tumor development, thereby maintaining cellular homeostasis. However, cancer cells can circumvent this
Externí odkaz:
https://doaj.org/article/56fbeca6658f458ab0ef871f85a4091e
Autor:
Dao Thi Huyen, Julien Reboud, Dao Thanh Quyen, Jonathan M. Cooper, Thirumalaisamy P. Velavan, Ngo Tat Trung, Le Huu Song
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Background Neisseria meningitidis can cause life-threatening meningococcal meningitis and meningococcemia. Old standard microbiological results from CSF/blood cultures are time consuming. This study aimed to combine the sensitivity of loop-m
Externí odkaz:
https://doaj.org/article/a729a03bcc60497893cacf0ff9e98438
Autor:
Ndyetabura O Theonest, Kennedy Ngowi, Elizabeth R Kussaga, Allen Lyimo, Davis Kuchaka, Irene Kiwelu, Dina Machuve, John-Mary Vianney, Julien Reboud, Blandina T Mmbaga, Jonathan M Cooper, Joram Buza
Publikováno v:
PLOS Digital Health, Vol 3, Iss 8, p e0000565 (2024)
IntroductionDiagnosis is a key step towards the provision of medical intervention and saving lives. However, in low- and middle-income countries, diagnostic services are mainly centralized in large cities and are costly. Point of care (POC) diagnosti
Externí odkaz:
https://doaj.org/article/15a758add08b425483fc5f6c87a02968
Autor:
Natasha Edwards, Julien Reboud, Xiaoxiang Yan, Xin Guo, Jonathan M. Cooper, Jemma Wadsworth, Ryan Waters, Valerie Mioulet, Donald P. King, Andrew E. Shaw
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals responsible for economic losses that amount to >$20 billion annually. Rapid recognition of FMD cases provides vital information to guide control programmes. A
Externí odkaz:
https://doaj.org/article/a86e977612ee4cffa9311555bcdb98da
Autor:
Mengyuan Lyu, Gaolian Xu, Jian Zhou, Julien Reboud, Yili Wang, Hongli Lai, Yi Chen, Yanbing Zhou, Guiying Zhu, Jonathan M. Cooper, Binwu Ying
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract Despite its importance, the functional heterogeneity surrounding the dynamics of interactions between mycobacterium tuberculosis and human immune cells in determining host immune strength and tuberculosis (TB) outcomes, remains far from unde
Externí odkaz:
https://doaj.org/article/243beb68e2aa4760b3fe5cb23810d075
Autor:
Mahsa Taherzadeh, Erjun Zhang, Irene Londono, Benjamin De Leener, Sophie Wang, Jonathan D. Cooper, Timothy E. Kennedy, Carlos R. Morales, Zesheng Chen, Gregory A. Lodygensky, Alexey V. Pshezhetsky
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionChronic progressive neuroinflammation is a hallmark of neurological lysosomal storage diseases, including mucopolysaccharidosis III (MPS III or Sanfilippo disease). Since neuroinflammation is linked to white matter tract pathology, we ana
Externí odkaz:
https://doaj.org/article/cafc015daf404af5b7297df4d90ee240
Autor:
Gaolian Xu, Hao Yang, Jiani Qiu, Julien Reboud, Linqing Zhen, Wei Ren, Hong Xu, Jonathan M. Cooper, Hongchen Gu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Rapid and facile detection of specific nucleic acid modifications could have numerous applications. Here the authors present Specific Terminal Mediated Polymerase Chain Reaction (STEM-PCR) as a generic and accessible approach, and demonstrate proof-o
Externí odkaz:
https://doaj.org/article/7eae19c80ff7465f9c676e515a53c0b9
Autor:
Yewande Pearse, Don Clarke, Shih-hsin Kan, Steven Q. Le, Valentina Sanghez, Anna Luzzi, Ivy Pham, Lina R. Nih, Jonathan D. Cooper, Patricia I. Dickson, Michelina Iacovino
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 452-463 (2022)
Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB) is a recessive genetic disorder that severely affects the brain due to a deficiency in the enzyme α-N-acetylglucosaminidase (NAGLU), leading to intra-lysosomal accumulation of partially de
Externí odkaz:
https://doaj.org/article/776a0875754d4cc8976309f509235d55
Publikováno v:
Advanced Science, Vol 10, Iss 24, Pp n/a-n/a (2023)
Abstract Phage‐inducible chromosomal islands (PICIs) are a family of phage satellites that hijack phage components to facilitate their mobility and spread. Recently, these genetic constructs are repurposed as antibacterial drones, enabling a new to
Externí odkaz:
https://doaj.org/article/3efc2380140d48e8b9e769ac00405bf1
Publikováno v:
eLife, Vol 12 (2023)
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear. We provide evidence that the Src-family kinase (SFK) sub
Externí odkaz:
https://doaj.org/article/11d09edf5ee84214b8d846a0b003f23e