Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

Autor: Jason Boehme, Natacha Le Moan, Rebecca J Kameny, Alexandra Loucks, Michael J Johengen, Amy L Lesneski, Wenhui Gong, Brian D Goudy, Tina Davis, Kevin Tanaka, Andrew Davis, Youping He, Janel Long-Boyle, Vijay Ivaturi, Jogarao V S Gobburu, Jonathan A Winger, Stephen P Cary, Sanjeev A Datar, Jeffrey R Fineman, Ana Krtolica, Emin Maltepe

Publikováno v: PLoS Biology, Vol 17, Iss 1, p e3000119 (2019)

[This corrects the article DOI: 10.1371/journal.pbio.2005924.].

Externí odkaz: https://doaj.org/article/eac3c42183f74da5877f5fc5b371e190

Assessment of tumor hypoxia in spontaneous canine tumors after treatment with OMX, a novel H-NOX oxygen carrier, with [18F]FMISO PET/CT

Autor: Sangkyung Choen, Michael S. Kent, F. Alexandra Loucks, Jonathan A. Winger, Allison L. Zwingenberger

Publikováno v: BMC Veterinary Research, Vol 20, Iss 1, Pp 1-9 (2024)

Abstract Background Hypoxia is a detrimental factor in solid tumors, leading to aggressiveness and therapy resistance. OMX, a tunable oxygen carrier from the heme nitric oxide/oxygen-binding (H-NOX) protein family, has the potential to reduce tumor h

Externí odkaz: https://doaj.org/article/6f914b97778b4f07af09ef02fb69da7b

E-023 Intravenous oxygen carrier therapy delays infarct size progression in a canine large vessel occlusion model

Autor: Matthew J. Gounis, L Kelly, Mohammed Salman Shazeeb, V Anagnostakou, Z Vardar, Jonathan A. Winger, Nils Henninger, Afif Kraitem, Robert M. King, J Kolstad, Ana Krtolica, Christopher M. Raskett

Publikováno v: Electronic Poster Abstracts.

Introduction Neuroprotective strategies represent a significant opportunity to delay infarct progression in patients suffering a Large Vessel Occlusion (LVO), allowing more time for treatment by mechanical thrombectomy. Oxygen carrier therapy has the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b68c8f2d02824c68d1e2c672ae9dc03
https://doi.org/10.1136/neurintsurg-2020-snis.59

TMIC-15. OMX IS A TUMOR MICROENVIRONMENT MODIFIER THAT RESTORES ANTI-TUMOR IMMUNITY AND IMPROVES ANTI-TUMOR EFFICACY BY REDUCING TUMOR HYPOXIA IN INTRACRANIAL GLIOBLASTOMA MOUSE MODEL

Autor: Ana Krtolica, Nicholas Butowski, Philberta Y. Leung, Natacha Le Moan, Jonathan A. Winger, Sarah Ng, Cary Stephen P L, Tina Davis

BACKGROUND: Intratumoral hypoxia is associated with resistance to chemo- and radio-therapies and poor patient outcomes. In addition, hypoxia promotes the immune escape of tumors by altering the recruitment and function of innate and adaptive immune e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1759145a35f5dba8ce9677ad7f0fc80
https://europepmc.org/articles/PMC6216340/

Identification of inhibitors of the association of ZAP-70 with the T cell receptor by high-throughput screen

Autor: Michelle R. Arkin, Kevin Lin, Christopher G. Wilson, Qingrong Yan, Patrick R. Visperas, Arthur Weiss, John Kuriyan, Jonathan A. Winger

Publikováno v: Visperas, PR; Wilson, CG; Winger, JA; Yan, Q; Lin, K; Arkin, MR; et al.(2017). Identification of inhibitors of the association of ZAP-70 with the T cell receptor by high-throughput screen. SLAS Discovery, 22(3), 324-331. doi: 10.1177/1087057116681407. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/2p06n6x6
SLAS discovery : advancing life sciences R & D, vol 22, iss 3

© 2016 Society for Laboratory. ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f67fda223d5eee7331c9be1cba39bf
http://www.escholarship.org/uc/item/2p06n6x6