Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jonathan A R Gordon"'
Autor:
Jonathan A R Gordon, Mark F Evans, Prachi N Ghule, Kyra Lee, Pamela Vacek, Brian L Sprague, Donald L Weaver, Gary S Stein, Janet L Stein
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282473 (2023)
The tumor microenvironment is a complex mixture of cell types that bi-directionally interact and influence tumor initiation, progression, recurrence, and patient survival. Mesenchymal stromal cells (MSCs) of the tumor microenvironment engage in cross
Externí odkaz:
https://doaj.org/article/79dc4743783b47faaf7a7026f4a06cdb
Autor:
Terri L Messier, Joseph R Boyd, Jonathan A R Gordon, Coralee E Tye, Natalie A Page, Rabail H Toor, Sayyed K Zaidi, Barry S Komm, Seth Frietze, Janet L Stein, Jane B Lian, Gary S Stein
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271725 (2022)
Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. One of the most persistent unresolved questions regarding menopausal ho
Externí odkaz:
https://doaj.org/article/23747e72e03144299f6791559e911b97
Autor:
Coralee E. Tye, Prachi N. Ghule, Jonathan A. R. Gordon, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Kirsten M. Tracy, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Bone formation requires osteogenic differentiation of multipotent mesenchymal stromal cells (MSCs) and lineage progression of committed osteoblast precursors. Osteogenic phenotype commitment is epigenetically controlled by genomic (chromatin
Externí odkaz:
https://doaj.org/article/cb869d076f7b42c0a921afee30acdf08
Autor:
Gillian L. Hirst, Thomas O'Keefe, Laura J. Esserman, Joseph Steward, Huazhen Yao, Janet L. Stein, Mark Evans, Adam Officer, Donald L. Weaver, Daniela Nachmanson, Alexander D. Borowsky, Olivier Harismendy, Jonathan A. R. Gordon, Brian L. Sprague, Hidetoshi Mori, Gary S. Stein, Kristen Jepsen, Farnaz Hasteh
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
NPJ Breast Cancer
NPJ breast cancer, vol 8, iss 1
NPJ Breast Cancer
NPJ breast cancer, vol 8, iss 1
The increased detection and treatment of early stage breast cancer as well as ductal carcinoma in situ (DCIS) has not led to significant survival benefits. Therefore, the current standard treatment of DCIS is questionable. An informed evidence-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14f6a7d864f9a96bac9fdfef6b44813
https://doaj.org/article/25a046ee37fb400db82cd80023557ef6
https://doaj.org/article/25a046ee37fb400db82cd80023557ef6
Autor:
Jane B. Lian, Jonathan A. R. Gordon, Nicole A. Bouffard, John H. Bushweller, Andrew J. Fritz, Joseph R. Boyd, Sayyed K. Zaidi, Gary S. Stein, Janet L. Stein, Anuradha Illendula, Joshua T. Rose, Eliana Moskovitz
Publikováno v:
Oncotarget
RUNX1 has recently been shown to play an important role in determination of mammary epithelial cell identity. However, mechanisms by which loss of the RUNX1 transcription factor in mammary epithelial cells leads to epithelial-to-mesenchymal transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c22be5f0cadf1a1bce7aec2bfdde17
http://europepmc.org/articles/PMC7335667
http://europepmc.org/articles/PMC7335667
Autor:
Jane B. Lian, Jason Kost, Joseph R. Boyd, Mark Fitzgerald, Seth Frietze, Deli Hong, Alqassem Abuarqoub, Prachi N. Ghule, Miles Malik, Janet L. Stein, John H. Bushweller, Sayyed K. Zaidi, Andrew J. Fritz, Jonathan A. R. Gordon, Sebastian Hanna, Kristiaan H. Finstaad, Gary S. Stein, Coralee E. Tye
Publikováno v:
J Cell Physiol
Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbfc0eb858b5dd7fd13c4948b57f8b9
https://doi.org/10.1002/jcp.29625
https://doi.org/10.1002/jcp.29625
Autor:
Prachi N. Ghule, Joseph R. Boyd, Sayyed K. Zaidi, Eric L Bolf, Jessica L. Heath, Kirsten Tracy, Janet L. Stein, Gary S. Stein, Seth Frietze, Andrew J. Fritz, Frances E. Carr, Coralee E. Tye, Diana L. Gerrard, Jane B. Lian, Jeffrey A. Nickerson, Jonathan A. R. Gordon, A. J. Van Wijnen, Deli Hong, Noelle E Gillis, Anthony N. Imbalzano, Joshua T. Rose, Princess D. Rodriguez
Publikováno v:
Genes Chromosomes Cancer
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4244f7c6e8bf2695661ab37de380471
https://doi.org/10.1002/gcc.22731
https://doi.org/10.1002/gcc.22731
Autor:
Coralee E. Tye, Gileade Pereira Freitas, Maria Paula O Gomes, Georgia K Quiles, Gary S. Stein, Adalberto Luiz Rosa, Alann T.P. Souza, Marcio Mateus Beloti, Helena Bacha Lopes, Jonathan A. R. Gordon, Jane B. Lian, Janet L. Stein
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Gene Ther
Universidade de São Paulo (USP)
instacron:USP
Gene Ther
Cell therapy is a valuable strategy for the replacement of bone grafts and repair bone defects and mesenchymal stem cells (MSCs) are the most frequently used cells. This study was designed to genetically edit MSCs to overexpress bone morphogenetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdd3a1f1cbac5eb42ed38d3b0f812ac
Autor:
Rayana L. Bighetti-Trevisan, Gary S. Stein, Adalberto Luiz Rosa, Luciana O. Almeida, Larissa Moreira Spinola de Castro-Raucci, Jane B. Lian, Janet L. Stein, Marcio Mateus Beloti, Jonathan A. R. Gordon, Coralee E. Tye
Publikováno v:
Biomater Adv
The bone remodeling process is crucial for titanium (Ti) osseointegration and involves the crosstalk between osteoclasts and osteoblasts. Considering the high osteogenic potential of Ti with nanotopography (Ti Nano) and that osteoclasts inhibit osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c5c5c4bd2acd1d4f70dae9ae740f94
https://doi.org/10.1016/j.msec.2021.112548
https://doi.org/10.1016/j.msec.2021.112548
Autor:
Eliana Moskovitz, Andrew J. Fritz, Joseph R. Boyd, Gary S. Stein, Janet L. Stein, John H. Bushweller, Sayyed K. Zaidi, Joshua T. Rose, Jonathan A. R. Gordon, Nicole A. Bouffard, Anuradha Illendula, Jane B. Lian
RUNX1 has recently been shown to play an important role in determination of mammary epithelial cell identity. However, mechanisms by which loss of the RUNX1 transcription factor in mammary epithelial cells leads to epithelial-to-mesenchymal transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdf6e6e42896334fd8c83a20c04cc0c