Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Jonathan A Javitch"'
Autor:
Daniel T Pederick, Nicole A Perry-Hauser, Huyan Meng, Zhigang He, Jonathan A Javitch, Liqun Luo
Publikováno v:
eLife, Vol 12 (2023)
The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner te
Externí odkaz:
https://doaj.org/article/14527b166af847cb97db84912bdfa479
Autor:
Ying Zhu, József Mészáros, Roman Walle, Rongxi Fan, Ziyi Sun, Andrew J Dwork, Pierre Trifilieff, Jonathan A Javitch
Publikováno v:
BioTechniques, Vol 68, Iss 3, Pp 122-129 (2020)
Despite the controversy regarding the existence and physiological relevance of class A G protein-coupled receptor dimerization, there is substantial evidence for functional interactions between the dopamine D2 receptor (D2R) and the adenosine A2A rec
Externí odkaz:
https://doaj.org/article/31c8c86ec0ef4ece99ee988a499d8c37
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd
Publikováno v:
BioTechniques, Vol 65, Iss 1, Pp 9-14 (2018)
Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. Methods to detect activities of G protein-coupled recep
Externí odkaz:
https://doaj.org/article/99b352e874484e2592c0a5f9724a88c4
Autor:
Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005948 (2018)
The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (
Externí odkaz:
https://doaj.org/article/c32595f0cebf4f86b145258df520dd63
Autor:
Zachary J Farino, Travis J Morgenstern, Julie Vallaghe, Nathalie Gregor, Prashant Donthamsetti, Paul E Harris, Nicolas Pierre, Robin Freyberg, Fabienne Charrier-Savournin, Jonathan A Javitch, Zachary Freyberg
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148684 (2016)
Direct measurement of insulin is critical for basic and clinical studies of insulin secretion. However, current methods are expensive and time-consuming. We developed an insulin assay based on homogenous time-resolved fluorescence that is significant
Externí odkaz:
https://doaj.org/article/d5d1b9e483904f1da5f84e0c75cfd217
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108232 (2014)
Macrophages are the primary cell type infected with HIV in the central nervous system, and infection of these cells is a major component in the development of neuropathogenesis and HIV-associated neurocognitive disorders. Within the brains of drug ab
Externí odkaz:
https://doaj.org/article/c21205dd64f34193987e3cafebc37caa
Autor:
Yi Wang, Jonathan A Javitch
Publikováno v:
eLife, Vol 2 (2013)
A fluorescent sensor that can monitor levels of extracellular ammonium has been made by using a fused green fluorescent protein to detect conformational changes in ammonium transport proteins.
Externí odkaz:
https://doaj.org/article/30ec1743864b48f29c5629897468de80
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16350 (2011)
The dopamine transporter (DAT), a member of the neurotransmitter:Na(+) symporter (NSS) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the treatment of at
Externí odkaz:
https://doaj.org/article/c1a59c49397440c68e10b74631eff9ed