Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jonathan A Harton"'
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006059 (2016)
Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly immature myeloid cells and subsequent myeloid cell death drive pa
Externí odkaz:
https://doaj.org/article/7d4cc131edf44f8eb05e164857f96d86
Autor:
Sivakumar Periasamy, Dorina Avram, Amanda McCabe, Katherine C MacNamara, Timothy J Sellati, Jonathan A Harton
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005517 (2016)
Inhalation of Francisella tularensis (Ft) causes acute and fatal pneumonia. The lung cytokine milieu favors exponential Ft replication, but the mechanisms underlying acute pathogenesis and death remain unknown. Evaluation of the sequential and system
Externí odkaz:
https://doaj.org/article/38d8b9a1238d413f823f6484938cf6b7
Autor:
Danielle Hunt, Justin E Wilson, Karis A Weih, Satoshi Ishido, Jonathan A Harton, Paul A Roche, James R Drake
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37330 (2012)
Francisella tularensis is a bacterial pathogen that uses host-derived PGE₂ to subvert the host's adaptive immune responses in multiple ways. Francisella-induced PGE₂ acts directly on CD4 T cells to blunt production of IFN-γ. Francisella-induced
Externí odkaz:
https://doaj.org/article/1edc20e6d02f4927a2fcde96ca812dc6
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11304 (2010)
The Pr55(gag) (Gag) polyprotein of HIV serves as a scaffold for virion assembly and is thus essential for progeny virion budding and maturation. Gag localizes to the plasma membrane (PM) and membranes of late endosomes, allowing for release of infect
Externí odkaz:
https://doaj.org/article/302dc69edf68432e96779c1617068a1c
Autor:
Abhinit Nagar, Jonathan A. Harton
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdebbe648990acaa560ec0fd581b5049
https://doi.org/10.1007/978-1-0716-3020-4_11
https://doi.org/10.1007/978-1-0716-3020-4_11
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Although considered the ternary inflammasome structure, whether the singular, perinuclear NLRP3:ASC speck is synonymous with the NLRP3 inflammasome is unclear. Herein we report that the NLRP3:ASC speck is not required for nigericin-induced inflammaso
Autor:
Jonathan A. Harton
Publikováno v:
Human Immunology. 80:32-36
In addition to their role in antigen presentation, class II MHC molecules also transmit signals to B lymphocytes. Class II MHC-mediated signals initiate a range of events in B cells, including induction of cell surface proteins, initiation of cell-cy
Autor:
Hongnga T. Le, Jonathan A. Harton
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and
Externí odkaz:
https://doaj.org/article/f668f6f1797f4016ab964aec7cee6988
Autor:
Abhinit Nagar, Tabassum Rahman, Jonathan A. Harton, Ellen B. Duffy, Kendi Okuda, Neal S. Silverman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view
Publikováno v:
Current Pharmacology Reports. 3:213-220
Recent findings regarding major histocompatibility complex (MHC) class II polymorphisms, sources of peptides, and regulation of expression on human pathologies are described with regards to impacts on human health. Studies of MHC class II polymorphis