Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Jonathan A Coles"'
Publikováno v:
Annals of Intensive Care, Vol 14, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/abc5ea2323024c4eb2fa022b6d9a8f54
Autor:
Jonathan A Coles, Elmarie Myburgh, Ryan Ritchie, Alana Hamilton, Jean Rodgers, Jeremy C Mottram, Michael P Barrett, James M Brewer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003714 (2015)
Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes meningoencephalitis. We have videoed the cortical meninges and superficial parenchyma of C56BL/6 reporter
Externí odkaz:
https://doaj.org/article/4f5c286785a64ef1b7a1deb687983e4d
Autor:
Tovah N Shaw, Phillip J Stewart-Hutchinson, Patrick Strangward, Durga B Dandamudi, Jonathan A Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M Brewer, Kevin N Couper, Michael L Dustin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005210 (2015)
There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the mechanisms through which they medi
Externí odkaz:
https://doaj.org/article/3f2002c434bb45ddb65f22c9102068f5
Autor:
Elmarie Myburgh, Jonathan A Coles, Ryan Ritchie, Peter G E Kennedy, Alex P McLatchie, Jean Rodgers, Martin C Taylor, Michael P Barrett, James M Brewer, Jeremy C Mottram
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2384 (2013)
HUMAN AFRICAN TRYPANOSOMIASIS (HAT) MANIFESTS IN TWO STAGES OF DISEASE: firstly, haemolymphatic, and secondly, an encephalitic phase involving the central nervous system (CNS). New drugs to treat the second-stage disease are urgently needed, yet test
Externí odkaz:
https://doaj.org/article/d8f63ebc485e4ac5958df2b230b0fd99
Autor:
Emmanuelle Grillon, Régine Farion, Katell Fablet, Michel De Waard, Chung Ming Tse, Mark Donowitz, Chantal Rémy, Jonathan A Coles
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17416 (2011)
Tumors create a heterogeneous acidic microenvironment which assists their growth and which must be taken into account in the design of drugs and their delivery. In addition, the acidic extracellular pH (pHe) is itself exploited in several experimenta
Externí odkaz:
https://doaj.org/article/b75a9372f4ec482cb5949cfef5850d27
Autor:
Annerixt Gribnau, Mark L. van Zuylen, Jonathan P. Coles, Mark P. Plummer, Henning Hermanns, Jeroen Hermanides
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2513 (2024)
Traumatic brain injury (TBI) is a major public health concern with significant consequences across various domains. Following the primary event, secondary injuries compound the outcome after TBI, with disrupted glucose metabolism emerging as a releva
Externí odkaz:
https://doaj.org/article/1da8f0d9b5ea4f46a4a15ce9881f16f2
Autor:
Tilak Das, Ruben Dammers, Emily Feilding, Vanessa Elliott, Laurence Glancz, Robert Grange, Peter Hartley, Felix Gooding, Dana Holl, Taj Hassan, Richard Knight, Julia Jones, Thais Minett, Val Luoma, George Peck, Stephen Novak, Ahmed-Ramadan Sadek, Shvaita Ralhan, Davina Richardson, Jennifer Ramshaw, Francoise Sheppard, Rebecca Rous, Katie Sheehan, David Shipway, Christelle Smit, Navneet Singh, Rhonda Sturley, Martin Smith, William Thomas, Michael Swart, Anthony Figaji, Crispin Weidmann, James Uprichard, David K Menon, Vickie Yeardley, Peter J Hutchinson, Paul M Brennan, Akbar Ansari, Christopher Corbett, Marilise Galea, Natalie Gray, Conor Gillespie, Harry Mee, Mary Dixon-Woods, Daniel J Stubbs, Thomas H Bashford, Benjamin M Davies, Diedrik Bulters, Philip Braude, Sophie Camp, Jonathan P Coles, Georgina Carr, Judith Dinsmore, Jugdeep Dhesi, Nicholas R Evans, Ellie Edlmann, Fiona Lecky, Emily Foster, Alexis Joannides, Angelos Kolias, Mike Nathanson, Iain Moppett, Nicola Owen, Virginia Newcombe, Amy Proffitt, Lisa Peterman, Sally R Wilson, Charlotte Skiterall, Ardalan Zolnourian, Peter Whitfield, Nick Borg, Meriem Amarouche, Charlotte Brown
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Introduction: A common neurosurgical condition, chronic subdural haematoma (cSDH) typically affects older people with other underlying health conditions. The care of this potentially vulnerable cohort is often, however, fragmented and suboptimal. In
Externí odkaz:
https://doaj.org/article/2915f8e6aaf94e3db55636303579cca2
Autor:
Xiaoyu Yang, Benjamin M. Davies, Jonathan P. Coles, David K. Menon, Daniel J. Stubbs, Aref-Ali Gharooni, Wunna Aung, Michelle L. Starkey, Douglas Hay, Fahim Anwar, Ivan S. Timofeev, Adel Helmy, Virginia F.J. Newcombe, Mark R.N. Kotter, Peter J.A. Hutchinson
Publikováno v:
Brain and Spine, Vol 3, Iss , Pp 102702- (2023)
Introduction: The epidemiology and prognosis of the isolated traumatic brain injury (TBI) and spinal cord injury (SCI) are well studied. However, the knowledge of the impact of concurrent neurotrauma is very limited. Research questions: To characteri
Externí odkaz:
https://doaj.org/article/2df8f66981ad416c8c1c08afdff00077
Autor:
Teerawit Audshasai, Jonathan A. Coles, Stavros Panagiotou, Shadia Khandaker, Hannah E. Scales, Morten Kjos, Murielle Baltazar, Julie Vignau, James M. Brewer, Aras Kadioglu, Marie Yang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The entry routes and translocation mechanisms of microorganisms or particulate materials into the central nervous system remain obscure We report here that Streptococcus pneumoniae (pneumococcus), or polystyrene microspheres of similar size,
Externí odkaz:
https://doaj.org/article/a69df22b4cba440db00265f14bfb2761
Publikováno v:
The Open Journal of Astrophysics, Vol 4 (2021)
We study the radial and azimuthal mass distribution of the lensing galaxy in WFI2033-4723. Mindful of the fact that modeling results depend on modeling assumptions, we examine two very different recent models: simply parametrized (SP) models from the
Externí odkaz:
https://doaj.org/article/1aaac99a893a4fa98289b6fd20f4d53c