Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jonathan A, Sheps"'
Autor:
Renxue Wang, Jonathan A. Sheps, Lin Liu, Jun Han, Patrick S.K. Chen, Jason Lamontagne, Peter D. Wilson, Ian Welch, Christoph H. Borchers, Victor Ling
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 85-97 (2019)
Bile acid imbalance causes progressive familial intrahepatic cholestasis type 2 (PFIC2) or type 3 (PFIC3), severe liver diseases associated with genetic defects in the biliary bile acid transporter bile salt export pump (BSEP; ABCB11) or phosphatidyl
Externí odkaz:
https://doaj.org/article/db1d6831af9842b0b39690e0a76d0744
Autor:
Ian Welch, Renxue Wang, Victor Ling, Lin Liu, Christoph H. Borchers, Jonathan A. Sheps, Peter R. Wilson, Patrick S. K. Chen, Jun Han, Jason Lamontagne
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 85-97 (2019)
Bile acid imbalance causes progressive familial intrahepatic cholestasis type 2 (PFIC2) or type 3 (PFIC3), severe liver diseases associated with genetic defects in the biliary bile acid transporter bile salt export pump (BSEP; ABCB11) or phosphatidyl
Autor:
Teng Liu, Jing Zhao, Jia-Yan Feng, Yi Lu, Jonathan A. Sheps, Ren-Xue Wang, Jun Han, Victor Ling, Jian-She Wang
Publikováno v:
Journal of Clinical and Translational Hepatology. :000-000
The aim was to determine if liver biochemistry indices can be used as biomarkers to help differentiate patients with neonatal Dubin-Johnson syndrome (nDJS) from those with biliary atresia (BA).Patients with genetically-confirmed nDJS or cholangiograp
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1866:158925
Bile acids are key components of bile required for human health. In humans and mice, conditions of reduced bile flow, cholestasis, induce bile acid detoxification by producing tetrahydroxylated bile acids (THBA), more hydrophilic and less cytotoxic t
Autor:
Renxue, Wang, Jonathan A, Sheps, Lin, Liu, Jun, Han, Patrick S K, Chen, Jason, Lamontagne, Peter D, Wilson, Ian, Welch, Christoph H, Borchers, Victor, Ling
Publikováno v:
Journal of lipid research. 60(1)
Bile acid imbalance causes progressive familial intrahepatic cholestasis type 2 (PFIC2) or type 3 (PFIC3), severe liver diseases associated with genetic defects in the biliary bile acid transporter bile salt export pump (BSEP; ABCB11) or phosphatidyl
Autor:
Jia-Qi Li, Teng Liu, Jing-Yu Gong, Neng-Li Wang, A S Knisely, Mei-Hong Zhang, Yan-Yan Yan, Christoph H. Borchers, Jonathan A. Sheps, Jian-She Wang, Lian Chen, Qing-He Xing, Yi Lu, Victor Ling, Jun Han, Bence Sipos, Jia-Yan Feng, Yi-Ling Qiu, Li-Ting Li, Ren-Xue Wang
Publikováno v:
Hepatology (Baltimore, Md.)
Hereditary cholestasis in childhood and infancy with normal serum gamma‐glutamyltransferase (GGT) activity is linked to several genes. Many patients, however, remain genetically undiagnosed. Defects in myosin VB (MYO5B; encoded by MYO5B) cause micr
Publikováno v:
Current Pharmaceutical Biotechnology. 12:636-646
The biliary secretion of bile acids is critical for multiple liver functions including digesting fatty nutrients and driving bile flow. When this process is impaired, the accumulating bile acids cause inflammatory liver injury. Multiple ABC transport
Publikováno v:
African Journal of Herpetology. 52:83-92
Africa (excluding the Seychelles) has a diverse caecilian fauna, including the endemic family Scolecomorphidae and six endemic genera of the more cosmopolitan Caeciliidae. Previous molecular phylogenetic studies have not included any caecilians from
Publikováno v:
Systematic Biology. 47:495-537
Many researchers working on the phyloge? netic analysis of nucleotide or amino acid se? quences find it necessary, at some time, to build upon prior work. When this involves importing an alignment (and masks) that have been des? cribed and sometimes
Autor:
Jonathan A. Sheps, Renxue Wang, Lin Liu, Victor Ling, Alan F. Hofmann, Lee R. Hagey, Dana Forrest
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 305(4)
The bile salt export pump (BSEP), encoded by the abcb11 gene, is the major canalicular transporter of bile acids from the hepatocyte. BSEP malfunction in humans causes bile acid retention and progressive liver injury, ultimately leading to end-stage