Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Jonathan A, Javitch"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different pharmacology compared to their homodimeric counterparts. Here, we use complemented donor-acceptor resonance energy transfer (CODA-RET) technology that
Externí odkaz:
https://doaj.org/article/3a700d9572124c27a40672d3dafdea71
Autor:
Václav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E. Pintar, Christopher Hwu, Rohini S. Ople, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and
Externí odkaz:
https://doaj.org/article/a56405d25d8040d397ce8623055b504b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Single-molecule FRET (smFRET) is a powerful imaging platform capable of revealing dynamic changes in the conformation and proximity of biological molecules. The expansion of smFRET imaging into living cells creates both numerous new research opportun
Externí odkaz:
https://doaj.org/article/e79b0c9b51604bc2ad840e75fa536cfc
Autor:
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101757- (2023)
Objective: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively. Most efficacious are so-calle
Externí odkaz:
https://doaj.org/article/a28f704e33e846e698b98299456a1403
Autor:
Daniel T Pederick, Nicole A Perry-Hauser, Huyan Meng, Zhigang He, Jonathan A Javitch, Liqun Luo
Publikováno v:
eLife, Vol 12 (2023)
The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner te
Externí odkaz:
https://doaj.org/article/14527b166af847cb97db84912bdfa479
Autor:
Alastair C. Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A. Javitch, J. Robert Lane
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.
Externí odkaz:
https://doaj.org/article/ac065c0033244eb3932a5b3f91103777
Autor:
Elizabeth A. Pekarskaya, Emma S. Holt, Jay A. Gingrich, Mark S. Ansorge, Jonathan A. Javitch, Sarah E. Canetta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Depression and anxiety, two of the most common mental health disorders, share common symptoms and treatments. Most pharmacological agents available to treat these disorders target monoamine systems. Currently, finding the most effective trea
Externí odkaz:
https://doaj.org/article/dacd9ec969a649caa396d38a5bf9a485
Autor:
Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin Strauss, Frank Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Brundu, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu, Sander Markx
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in CNTNAP2 have been associated with a syndromic form of Autism Spectrum Disorder. Here the authors show that forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of ASD with a homozygous trunc
Externí odkaz:
https://doaj.org/article/23d0c5b97fef4d90b66fccf00b3134ee
Autor:
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalizati
Externí odkaz:
https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
Autor:
Anika Mann, Alastair C. Keen, Hanka Mark, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals, Stefan Schulz, J. Robert Lane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and inter
Externí odkaz:
https://doaj.org/article/ca749480bcc9489bb045eb4ed1f42bf3