Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jonathan R. Daft"'
Publikováno v:
Molecules, Vol 14, Iss 9, Pp 3339-3352 (2009)
A general scheme for the synthesis of C8-arylpurine phosphoramidites has been developed. C8-Arylation of C8-bromo-2′-deoxyguanosine is the key step and has been achieved through the use of a Suzuki coupling. Since the coupling reaction is conducted
Externí odkaz:
https://doaj.org/article/ff602d92d3684577a91ff9490ba6fc75
Autor:
A.D. Adema, Jonathan R. Daft, E. K. Hoebe, Marco Radi, G.J. Peters, J. Narayanasamy, L. E. Alexander, Chung K. Chu
Publikováno v:
Nucleosides, nucleotides & nucleic acids, 26(8-9), 1073-1077. Marcel Dekker Inc.
Troxacitabine is a cytotoxic deoxycytidine analogue with an unnatural L-configuration, which is activated by deoxycytidine kinase (dCK). The configuration is responsible for differences in the uptake and metabolism of troxacitabine compared to other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2903fd014ea48d72193a5566a516c77d
https://doi.org/10.1080/15257770701515591
https://doi.org/10.1080/15257770701515591
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:1272-1275
A general scheme for the synthesis of (S)-6-methoxy-2-propanoic acid (naproxen) deuterated on the naphthyl ring, methoxy group, or both, is described. The resulting labeled naproxen derivatives are useful probes for examining atypical kinetics displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f854e723c9a601236906c5429cde9d82
https://doi.org/10.1002/jlcr.1451
https://doi.org/10.1002/jlcr.1451
Publikováno v:
Journal of AOAC INTERNATIONAL. 85:1177-1180
Water-miscible solvents, such as acetone and acetonitrile, effectively extract both polar and nonpolar pesticide residues from nonfatty foods. The addition of sodium chloride to the resulting acetonitrile–water or acetone–water extract (salting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2f2a1ac0a136be7d0b6b54cefcbfb3
https://doi.org/10.1093/jaoac/85.5.1177
https://doi.org/10.1093/jaoac/85.5.1177
Autor:
Min Ding, Jonathan R. Daft, Yun Zhang, Peter M. Gannett, Jianping Ye, Xianglin Shi, Eva Darian, Jeannine H. Powell
Publikováno v:
Chemical Research in Toxicology. 13:1020-1027
Arenediazonium ions such as those found in the common mushroom Agaricus bisporus have been convincingly demonstrated to be tumorigenic. The specific mechanism of their tumorigenicity remains unclear. It has been shown that arenediazonium ions can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38bb6103cc706edada34ce0ffcbb1a0
https://doi.org/10.1021/tx000068s
https://doi.org/10.1021/tx000068s
Autor:
Eveline K. Hoebe, Godefridus J. Peters, Auke D. Adema, Chung K. Chu, Lou-Ella M. M. Alexander, Jong H. Cho, Marco Radi, Jonathan R. Daft
Publikováno v:
Journal of medicinal chemistry, 50(9), 2249-2253. American Chemical Society
l-1,3-Dioxolane-cytidine, a potent anticancer agent against leukemia, has limited efficacy against solid tumors, perhaps due to its hydrophilicity. Herein, a library of prodrugs were synthesized to optimize in vitro antitumor activity against non-sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac89060b027bdf1e3f9df988210a8cb2
https://pure.amc.nl/en/publications/in-vitro-optimization-of-nonsmall-cell-lung-cancer-activity-with-troxacitabine-l13dioxolanecytidine-prodrugs(b694a4df-8eb3-46d0-a7c5-7e640d8191ce).html
https://pure.amc.nl/en/publications/in-vitro-optimization-of-nonsmall-cell-lung-cancer-activity-with-troxacitabine-l13dioxolanecytidine-prodrugs(b694a4df-8eb3-46d0-a7c5-7e640d8191ce).html
Autor:
Jon D. Epperson, Peter M. Gannett, Kevin H. Shaughnessy, Sue Heavner, Jonathan R. Daft, Nancy L. Greenbaum
Publikováno v:
Chemical research in toxicology. 16(10)
Carcinogenic aryl hydrazines produce C8-arylated purine adducts. The effect of these adducts on DNA conformation and their role in hydrazine carcinogenesis are unknown. Here, we describe a new synthetic route to produce these adducts that is also com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b72b9eb65d3998895b53765a66ecf2
https://pubmed.ncbi.nlm.nih.gov/14565779
https://pubmed.ncbi.nlm.nih.gov/14565779
Autor:
Edward M. Johnson, Peter M. Gannett, Kevin H. Shaughnessy, Elizabeth C. Western, Jonathan R. Daft
Publikováno v:
The Journal of organic chemistry. 68(17)
Modification of nucleosides to give pharmaceutically active compounds, mutagenesis models, and oligonucleotide structural probes continues to be of great interest. The aqueous-phase modification of unprotected halonucleosides is reported herein. Usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e83eef210b56d7455dfdf81ad99f55
https://pubmed.ncbi.nlm.nih.gov/12919046
https://pubmed.ncbi.nlm.nih.gov/12919046
Autor:
Devona James, Blanche F. Rybeck, Peter M. Gannett, Jonathan R. Daft, James B. Knopp, Timothy S. Tracy
Publikováno v:
Journal of analytical toxicology. 25(6)
Barbiturates are widely used as sedatives, hypnotics, and antiepileptics, and, when coupled with their narrow therapeutic index, the probability that their use will result in accidental or intentional death is significant. When barbiturates are impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4d4772e8440e1447935905e79a7d3
https://pubmed.ncbi.nlm.nih.gov/11550818
https://pubmed.ncbi.nlm.nih.gov/11550818
Autor:
Seble Hailu, Blanche F. Rybeck, Devona James, Timothy S. Tracy, Jonathan R. Daft, Peter M. Gannett
Publikováno v:
ResearcherID
Embalming is common, and it can create problems for the forensic scientist if a drug has been the cause death and this drug is also reactive toward the embalming fluid. Previous studies have focused on the tricyclic amines nortriptyline and desiprami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2f2074b4d45eedd039100995de1456
https://pubmed.ncbi.nlm.nih.gov/11300512
https://pubmed.ncbi.nlm.nih.gov/11300512