Výsledky vyhledávání - "Jonathan, Uy"

Demographics, Disease Characteristics, and Patient-Reported Outcomes Among Patients with Psoriasis Who Initiated Guselkumab in CorEvitas’ Psoriasis Registry

Autor: Timothy Fitzgerald, Jessica A. Walsh, Kristina Callis Duffin, Katelyn Rowland, Wendi Malley, Joseph F. Merola, Robert R. McLean, Amanda Teeple, Angel Cronin, Soumya D. Chakravarty, Abby S. Van Voorhees, Jonathan Uy

Publikováno v: Dermatology and Therapy

Introduction Guselkumab is approved for the treatment of both moderate-to-severe plaque psoriasis and active psoriatic arthritis (PsA) in the USA. However, little is known about patients initiating guselkumab in a real-world setting. The objective of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fbe07c244d3f050b7b7a9f6669b9c8
https://doi.org/10.1007/s13555-021-00637-2

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Trip Generation Study of a Shuttle Service System in Southville 7

Autor: Angelo Josh Custodio, Jacob Layug, Joenel G. Galupino, Jonathan Uy, Maria Cecilia Paringit, Reil Dominic Catolos, Paolo Ian Lucero

Publikováno v: Transportation Research Procedia. 48:2844-2851

The current income of the residents of Southville 7 in Calauan, Laguna is not sufficient to support their everyday expenses and one of the main reasons why they could not save is that they are spending too much on transportation costs. Therefore, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::469c319da8adadfa8a3c5562bca1de31
https://doi.org/10.1016/j.trpro.2020.08.234

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Signal Detection and Methodological Limitations in a Real-World Registry: Learnings from the Evaluation of Long-Term Safety Analyses in PSOLAR

Autor: Steven Fakharzadeh, Alice B. Gottlieb, Bruce Strober, Jesse A. Berlin, Kim A. Papp, Jonathan Uy, Richard G. Langley, Emily S. Brouwer, Robert Bissonnette, Wayne Langholff, Craig L. Leonardi, Kim Parnell Lafferty, Andrew Greenspan, David M. Pariser

Publikováno v: Drug Safety

Introduction Psoriasis Longitudinal Assessment and Registry (PSOLAR) was designed in 2007 as the first disease-based registry for patients with psoriasis. Objective The aim of this study was to discuss methodological limitations and post hoc analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1227de0316c1b456cfebb5474bf2b194
https://pubmed.ncbi.nlm.nih.gov/34075572

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Akademický článek

Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings.

Publikováno v: PLoS Medicine, Vol 9, Iss 8, p e1001290 (2012)

BackgroundAntiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-dai

Externí odkaz: https://doaj.org/article/28bce7526ebb4cd2809cf9e8b4bd1e1a

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Akademický článek

Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.

Autor: Max Lataillade, Jennifer Chiarella, Rong Yang, Michelle DeGrosky, Jonathan Uy, Daniel Seekins, Birgitte Simen, Elizabeth St John, Elizabeth Moreno, Michael Kozal

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30118 (2012)

It is unknown whether HIV-positive patients experiencing virologic failure (VF) on boosted-PI (PI/r) regimens without drug resistant mutations (DRM) by standard genotyping harbor low-level PI resistant variants. CASTLE compared the efficacy of atazan

Externí odkaz: https://doaj.org/article/26adf67fd8fc4adaaab99d6ab3617dd8

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Akademický článek

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study.

Autor: Max Lataillade, Jennifer Chiarella, Rong Yang, Steven Schnittman, Victoria Wirtz, Jonathan Uy, Daniel Seekins, Mark Krystal, Marco Mancini, Donnie McGrath, Birgitte Simen, Michael Egholm, Michael Kozal

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e10952 (2010)

CASTLE compared the efficacy of atazanavir/ritonavir with lopinavir/ritonavir, each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents.Determine the baseline rate and clinical significance of TDR mutations using ultr

Externí odkaz: https://doaj.org/article/8375a24f827a4f72b10609d3e67974e1

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CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects

Autor: Xiaohui Xu, Blisse Vakkalagadda, Ellen Chung, Li Zhu, David M. Burger, Jonathan Uy, Richard Bertz, Roger J. M. Brüggemann, K. Sims, Ron H.N. van Schaik, Matthew Hruska, Angela Colbers

Publikováno v: The Journal of Clinical Pharmacology. 57:235-246

Voriconazole, a broad-spectrum triazole antifungal agent, is metabolized by cytochrome P450 (CYP) 2C19 and, to a lesser extent, by CYP3A. Genetic polymorphism of CYP2C19 not only plays a prominent role in its disposition but may also influence potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9cca1ada7d1e4f81a670eaf56517591
https://doi.org/10.1002/jcph.798

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Changes in Biomarkers in HIV-1-Infected Treatment-Naive Patients Treated with Tenofovir DF/Emtricitabine plus Atazanavir/Ritonavir or Lopinavir/Ritonavir for 96 Weeks: The CASTLE Biomarker Substudy

Autor: Maria Jesus Jimenez-Exposito, Jonathan Uy, Neelanjana Ray, Donnie McGrath, Edwin DeJesus, Graeme Moyle, Helene Hardy

Publikováno v: Antiviral Therapy. 19:693-699

Background The impact of boosted protease inhibitor therapy on inflammatory and cardiovascular biomarker levels in treatment-naive HIV-infected patients remains unclear and may differ between agents. Unconjugated bilirubin elevation, which favourably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efb5d5e87da6ac65a0e3b81d9909c02
https://doi.org/10.3851/imp2778

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