Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonathan, Sheard"'
Autor:
Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi, Badrul Hisham Yahaya
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-21 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, stem cell-based appro
Externí odkaz:
https://doaj.org/article/b578f88ff1d740f1ac709eb36548bdc2
Autor:
Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Darius Widera, Ketan Patel
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would repl
Externí odkaz:
https://doaj.org/article/71390462c4da442ea58f57b8dc9a8551
Autor:
Donata Iandolo, Jonathan Sheard, Galit Katarivas Levy, Charalampos Pitsalidis, Francesca Santoro, Athina E. Markaki, Darius Widera, Rόisín M. Owens
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100380- (2020)
Externí odkaz:
https://doaj.org/article/f3a187b5842a40f3913efdf375cea2d7
Autor:
Mesude Bicer, Jonathan Sheard, Donata Iandolo, Samuel Y. Boateng, Graeme S. Cottrell, Darius Widera
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1696 (2020)
Due to the ageing population, there is a steadily increasing incidence of osteoporosis and osteoporotic fractures. As conventional pharmacological therapy options for osteoporosis are often associated with severe side effects, bone grafts are still c
Externí odkaz:
https://doaj.org/article/5ababa018b1542a2ac24e441a01cef87
Autor:
Federica Lorenzi, Roya Babaei-Jadidi, Jonathan Sheard, Bradley Spencer-Dene, Abdolrahman S Nateri
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Colorectal cancer (CRC) is one of the top three cancer-related causes of death worldwide. FBXW7 is a known tumor-suppressor gene, commonly mutated in CRC and in a variety of other epithelial tumors. Low expression of FBXW7 is also associated with poo
Externí odkaz:
https://doaj.org/article/bda010818adb48e3a9949922dd217d74
Autor:
Charalampos Pitsalidis, Ellasia Tan, Galit Karavitas Levy, Darius Widera, Donata Iandolo, Ji-Seon Kim, Anthony R. Dennis, Athina E. Markaki, Jonathan Sheard, Róisín M. Owens
Publikováno v:
MRS Communications. 10:179-187
Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e28a31c5fe09e9249dc71232494873
https://doi.org/10.1557/mrc.2020.10
https://doi.org/10.1557/mrc.2020.10
Autor:
Bhumika, Singh, Mohamed Essameldin, Abdelgawad, Zulfiqur, Ali, Jarrod, Bailey, Elisa, Budyn, Prospero, Civita, Martin J D, Clift, John T, Connelly, Samuel, Constant, Marius, Hittinger, Helena, Kandarova, Victoria Rosalind, Kearns, Tony, Kiuru, Tomasz, Kostrzewski, Sebastian, Kress, Victoria Marsh, Durban, Claus-Michael, Lehr, Hayley, McMillan, Julia Katharina, Metz, Vivian, Monteban, Dania, Movia, Catia, Neto, Carla, Owen, Lauri, Paasonen, Kerri Anne, Palmer, Geoffrey John, Pilkington, Karen, Pilkington, Adriele, Prina-Mello, Clive, Roper, Jonathan, Sheard, Sheree, Smith, Janette Ellen, Turner, Ipsita, Roy, Melissa Anne, Tutty, Eirini, Velliou, John Malcolm, Wilkinson
Publikováno v:
Alternatives to laboratory animals : ATLA. 49(3)
Experimental systems that faithfully replicate human physiology at cellular, tissue and organ level are crucial to the development of efficacious and safe therapies with high success rates and low cost. The development of such systems is challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18333ba90fd4ecdb62c6bab88e1d8aa6
https://pubmed.ncbi.nlm.nih.gov/34225465
https://pubmed.ncbi.nlm.nih.gov/34225465
Autor:
Jonathan Sheard, Rocío Martínez Aguilar, Alessia Frigo, Yiming Meng, Thomas M. Vallance, Darius Widera, Donata Iandolo, Mesude Bicer
Publikováno v:
Stem Cells International
Stem Cells International, Vol 2019 (2019)
Stem Cells International, Vol 2019 (2019)
The anti-inflammatory and immunomodulatory properties of human mesenchymal stromal cells (MSCs) are a focus within regenerative medicine. However, 2D cultivation of MSCs for extended periods results in abnormal cell polarity, chromosomal changes, red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc24bc1e4f7af68114cfc971c385489b
https://doi.org/10.1155/2019/3106929
https://doi.org/10.1155/2019/3106929
Autor:
William E. B. Johnson, Christopher M. Bunce, Martyn D. Snow, Max A Ellington, Andrew D. Southam, Hannah L. Mackay, Jonathan Sheard, Farhat L. Khanim
Publikováno v:
Bioscience Reports
Drug repurposing is a cost-effective means of targeting new therapies for cancer. We have examined the effects of the repurposed drugs, bezafibrate, medroxyprogesterone acetate and valproic acid on human osteosarcoma cells, i.e., SAOS2 and MG63 compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286e5918a0eefae4b0ec0ec75d7f59e8
https://doi.org/10.1042/bsr20202505
https://doi.org/10.1042/bsr20202505
Autor:
Prospero Civita, Hayley McMillan, Catia Neto, Sheree Smith, Vivian Monteban, Lauri Paasonen, Victoria Kearns, Bhumika Singh, Kerri Palmer, Mohamed Essameldin Abdelgawad, Julia Katharina Metz, Martin J. D. Clift, Samuel Constant, Jarrod Bailey, Claus-Michael Lehr, Ipsita Roy, Adriele Prina-Mello, Karen Pilkington, Geoffrey J. Pilkington, Dania Movia, Melissa Anne Tutty, Tony Kiuru, Elisa Budyn, Zulfiqur Ali, John Malcolm Wilkinson, Tomasz Kostrzewski, Victoria Marsh Durban, Carla Owen, Jonathan Sheard, Helena Kandarova, Clive Roper, Eirini Velliou, John T. Connelly, Janette Ellen Turner, Marius Hittinger, Sebastian Kress
Publikováno v:
Alternatives to laboratory animals : ATLA
England
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
ATLA Alternatives to Laboratory Animals
England
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
ATLA Alternatives to Laboratory Animals
Experimental systems that faithfully replicate human physiology at cellular, tissue and organ level are crucial to the development of efficacious and safe therapies with high success rates and low cost. The development of such systems is challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8988ab9c4803495a5cb1c9d4864c2090
https://cronfa.swan.ac.uk/Record/cronfa57289/Download/57289__20529__872b5658a37a4c01a75e6229a0ad1494.pdf
https://cronfa.swan.ac.uk/Record/cronfa57289/Download/57289__20529__872b5658a37a4c01a75e6229a0ad1494.pdf
