Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jonathan, Parkinson"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
High-affinity antibodies are often identified through directed evolution but deep leaning methods hold great promise. Here the authors report RESP, a pipeline for efficient identification of high affinity antibodies, and apply this to the PD-L1 antib
Externí odkaz:
https://doaj.org/article/0b227fcca1014840a15034f12b0b13f8
Autor:
Simon Chadwick, Lachlan Donaldson, Pierre Janin, Archie Darbar, Rosie Sutherland, Oliver Flower, Naomi Hammond, Jonathan Parkinson, Anthony Delaney
Publikováno v:
Journal of Clinical Neuroscience. 110:80-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8469afd566d8a53860aee8d8b44fb6
https://doi.org/10.1016/j.jocn.2023.02.005
https://doi.org/10.1016/j.jocn.2023.02.005
Publikováno v:
Proceedings of the Institution of Civil Engineers - Engineering Sustainability. 175:224-235
Climate risk and vulnerability assessments were undertaken in the Caribbean for national ministries, with funding from the Caribbean Development Bank. The studies evaluated the impacts of climate-related natural hazards on road transport infrastructu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5569127ff9de6eb8b3145cfd3e8a19
https://doi.org/10.1680/jensu.21.00008
https://doi.org/10.1680/jensu.21.00008
Publikováno v:
Proceedings of the Institution of Civil Engineers - Municipal Engineer. 175:123-134
The paper assesses the potential for adopting sustainable urban drainage systems (SUDS) in Myanmar to mitigate flood risks related to urbanisation. Fieldwork in commercial and industrial developments and informal settlements was undertaken to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3304c983f78b5f2e45450697dba8ba57
https://doi.org/10.1680/jmuen.21.00042
https://doi.org/10.1680/jmuen.21.00042
Publikováno v:
Waterlines. 40:192-208
As part of the UK Government-funded Ideas to Impact programme, the Sanitation Challenge for Ghana (SC4Gh) ran from 2015 to 2019 aiming to incentivize local authorities in Ghana to prioritize resources to improve municipal sanitation services towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed3b7b7a0e828ad43e62c89e675e978
https://doi.org/10.3362/1756-3488.21-00005
https://doi.org/10.3362/1756-3488.21-00005
Publikováno v:
Proteins
JMJD2A is a histone lysine demethylase which recognizes and demethylates H3K9me3 and H3K36me3 residues and is overexpressed in various cancers. It utilizes a tandem tudor domain to facilitate its own recruitment to histone sites, recognizing various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20192e84dec58ffecdecf538731c5386
https://pubmed.ncbi.nlm.nih.gov/35927178
https://pubmed.ncbi.nlm.nih.gov/35927178
Autor:
Francie Barron, Hsiang-Wei Lu, Elizabeth Celaya, Regis Peytavi, Jonathan Parkinson, Sarah Balderston, Kenneth Dickerson, Philip G. Collins, Juan José Ripoll, Daehwan Kim, Reza Hajian, Simonas Kutanovas, Virginijus Siksnys, Giedrius Gasiunas, Irina M. Conboy, Brett R. Goldsmith, Kandace Fung, Amanda Jiao, Kiana Aran, Jeffrey Taulbee, Kasey Smith
Publikováno v:
Nature Biomedical Engineering. 5:713-725
Simple and fast methods for the detection of target genes with single-nucleotide specificity could open up genetic research and diagnostics beyond laboratory settings. We recently reported a biosensor for the electronic detection of unamplified targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0532526d1ad41d0584340057c7af386
https://doi.org/10.1038/s41551-021-00706-z
https://doi.org/10.1038/s41551-021-00706-z
Autor:
Olga Lomovskaya, Maxim Totrov, Dongxu Sun, K. Raja Reddy, Tomasz W. Glinka, Mojgan Sabet, Debora Rubio-Aparicio, Serge H. Boyer, Orville A. Pemberton, Ruslan Tsivkovski, Scott J. Hecker, Michael N. Dudley, David C. Griffith, Jonathan Parkinson, Kirk Nelson, Yu Chen, Ziad Tarazi
Publikováno v:
Journal of Medicinal Chemistry. 63:7491-7507
Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0120b5dd24d3ace9b34c3d9db7858b70
https://doi.org/10.1021/acs.jmedchem.9b01976
https://doi.org/10.1021/acs.jmedchem.9b01976
Publikováno v:
Artificial Intelligence in Healthcare and Medicine ISBN: 9781003120902
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402a3ff4cd5b7a3ba5b4aa8224e70e22
https://doi.org/10.1201/9781003120902-1
https://doi.org/10.1201/9781003120902-1
Autor:
Ziad Tarazi, K. Raja Reddy, Olga Lomovskaya, Jonathan Parkinson, Michael N. Dudley, Serge H. Boyer, Scott J. Hecker, David C. Griffith, Mojgan Sabet
Publikováno v:
Journal of medicinal chemistry. 64(23)
In recognition of the need for effective oral therapies to treat Gram-negative bacterial infections, efforts were directed toward identifying an oral prodrug of β-lactamase inhibitor clinical candidate QPX7728. Seventeen prodrugs were synthesized; k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d60110ef6fc895102d041e03ea9e74
https://pubmed.ncbi.nlm.nih.gov/34817182
https://pubmed.ncbi.nlm.nih.gov/34817182