Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jonathan, Iaconelli"'
Autor:
Yeonjin Ko, Mannkyu Hong, Seungbeom Lee, Manoj Kumar, Lara Ibrahim, Kayla Nutsch, Caroline Stanton, Phillip Sondermann, Braddock Sandoval, Maya L. Bulos, Jonathan Iaconelli, Arnab K. Chatterjee, R. Luke Wiseman, Peter G. Schultz, Michael J. Bollong
Publikováno v:
Proceedings of the National Academy of Sciences. 120
KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the presence of electrophilic agents by modification of its sensor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9942402c6cf77a38e8f7f6272daca91
https://doi.org/10.1073/pnas.2300763120
https://doi.org/10.1073/pnas.2300763120
Autor:
Shrikanta Chattopadhyay, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Radhika Subramanian, Leigh C. Carmody, Rushdia Z. Yusuf, David B. Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D. Cirstea, Teru Hideshima, Vlado Dančík, Max M. Majireck, Mahmud M. Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J. Tolliday, Paul A. Clemons, Malcolm A.S. Moore, Andrew M. Stern, Alykhan F. Shamji, Benjamin L. Ebert, Todd R. Golub, Noopur S. Raje, David T. Scadden, Stuart L. Schreiber
Publikováno v:
Cell Reports, Vol 10, Iss 5, Pp 755-770 (2015)
Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance. One such compou
Externí odkaz:
https://doaj.org/article/82708c323e2f4ecd99ce9d25576f54c6
Autor:
Jeyun Jo, Jisu Kim, Lara Ibrahim, Manoj Kumar, Jonathan Iaconelli, Cong So Tran, Hyung Ryong Moon, Yunjin Jung, R. Luke Wiseman, Luke L. Lairson, Arnab K. Chatterjee, Michael J. Bollong, Hwayoung Yun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 89:129306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600a07bb58eb970320926cc4e0a8362
https://doi.org/10.1016/j.bmcl.2023.129306
https://doi.org/10.1016/j.bmcl.2023.129306
Autor:
Jason S. Chen, Benjamin F. Cravatt, Jonathan Iaconelli, Minseob Koh, Michael J. Bollong, Peter G. Schultz, Ekaterina V. Vinogradova, Stormi R Chadwick, Kristine Senkane, Xiaotian Qi, Peng Liu, Arnab Chatterjee, Claudio Zambaldo, Radu M. Suciu, Brittany Sanchez
Publikováno v:
J Am Chem Soc
The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd4de3fdea02c9acf05e1b892583211
https://doi.org/10.1021/jacs.0c02721
https://doi.org/10.1021/jacs.0c02721
Autor:
Mitchell V. Hull, Emily I. Chen, Michael J. Bollong, Jonathan Iaconelli, Lara Ibrahim, Peter G. Schultz
Publikováno v:
ChemBioChem. 21:1816-1819
The transcription factor nuclear factor erythroid 2-related factor 1 (NRF1) maintains proteostasis and promotes cellular resilience by stimulating the transcription of proteasomal subunits and a host of protective enzymes. Although NRF1 activation wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7782a487d8f754da56c1e5b01cb777cb
https://doi.org/10.1002/cbic.201900487
https://doi.org/10.1002/cbic.201900487
Autor:
Sophia Z, Shalhout, Peng-Yu, Yang, Edyta M, Grzelak, Kayla, Nutsch, Sida, Shao, Claudio, Zambaldo, Jonathan, Iaconelli, Lara, Ibrahim, Caroline, Stanton, Stormi R, Chadwick, Emily, Chen, Michael, DeRan, Sijia, Li, Mitchell, Hull, Xu, Wu, Arnab K, Chatterjee, Weijun, Shen, Fernando D, Camargo, Peter G, Schultz, Michael J, Bollong
Publikováno v:
Nature chemical biology. 17(7)
The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::113abd6d43aecc5052478625d0c29143
https://pubmed.ncbi.nlm.nih.gov/33758335
https://pubmed.ncbi.nlm.nih.gov/33758335
Autor:
Rakesh Karmacharya, Bangyan Liu, Jasmin Lalonde, Bradley Watmuff, Ralph Mazitschek, Stephen J. Haggarty, Jonathan Iaconelli
Publikováno v:
ACS Chemical Biology. 12:2139-2148
AKT family of serine-threonine kinases functions downstream of phosphatidylinositol 3-kinase (PI3K) to transmit signals by direct phosphorylation of a number of targets, including the mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f6ef247c3fdd9376d2b4b9470d60a8
https://doi.org/10.1021/acschembio.6b01014
https://doi.org/10.1021/acschembio.6b01014
Autor:
Rakesh Karmacharya, Hyoungjun Park, Bradley Watmuff, Dost Öngür, Clary B. Clish, Bruce M. Cohen, Shaunna S. Berkovitch, Joanne H. Huang, Donna L. McPhie, Jonathan Iaconelli
Publikováno v:
Journal of Proteome Research. 16:481-493
We undertook an unbiased metabolite profiling of fibroblasts from schizophrenia patients and healthy controls to identify metabolites and pathways that are dysregulated in disease, seeking to gain new insights into the disease biology of schizophreni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c64fc3dc157be815d17a0720d30d46
https://doi.org/10.1021/acs.jproteome.6b00628
https://doi.org/10.1021/acs.jproteome.6b00628
Autor:
Dost Öngür, Clary B. Clish, Rakesh Karmacharya, Bruce M. Cohen, Jonathan Iaconelli, Shrikanta Chattopadhyay, Hyoungjun Park, Donna L. McPhie, Bradley Watmuff, Shaunna S. Berkovitch, Joanne H. Huang
Publikováno v:
Complex Psychiatry. 2:97-106
Many studies suggest the presence of aberrations in cellular metabolism in bipolar disorder. We studied the metabolome in bipolar disorder to gain insight into cellular pathways that may be dysregulated in bipolar disorder and to discover evidence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2425e8aee42a8c8a68cfb371e9e83d1
https://doi.org/10.1159/000446654
https://doi.org/10.1159/000446654
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1605 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Recent studies show that histone deacetylase 6 (HDAC6) has important roles in the human brain, especially in the context of a number of nervous system disorders. Animal models of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3a38fdcaa1bdf27ddecca53b11bc4f
https://doi.org/10.3390/ijms20071605
https://doi.org/10.3390/ijms20071605