Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jonathan, Cairns"'
Autor:
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)
Abstract Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liv
Externí odkaz:
https://doaj.org/article/6ef35220f5cb430495895d01dab6b095
Autor:
Chang Sik Kim, Jonathan Cairns, Valentina Quarantotti, Bogumil Kaczkowski, Yinhai Wang, Peter Konings, Xiang Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/4f33d187a553428d97c588702d30bf3f
Autor:
Jonathan Cairns, Emilyanne Leonard, Kainat Khan, Conor Parks, Gareth Maglennon, Bairu Zhang, Stanley E. Lazic, Lorna Ewart, Rhiannon David
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Microphysiological systems (MPS; organ-on-a-chip) aim to recapitulate the 3D organ microenvironment and improve clinical predictivity relative to previous approaches. Though MPS studies provide great promise to explore treatment options
Externí odkaz:
https://doaj.org/article/1257d15b6da04bb7825cb361187ba6d5
Autor:
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G. Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A. César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W. Wingett, Peter Fraser
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation. In p
Externí odkaz:
https://doaj.org/article/9a210e18686b41e2bfd4786eebcb2e8a
Autor:
Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibit
Externí odkaz:
https://doaj.org/article/7547983126794fc0a17cf1c4d462a298
Autor:
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W. Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J. Rugg-Gunn
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Summary: Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active ch
Externí odkaz:
https://doaj.org/article/a9fe24befd3e4a119da1557f07e1eacc
Autor:
Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates iden
Externí odkaz:
https://doaj.org/article/a2ac010742a3449aa23a667a36cbedcf
Autor:
Romina Petersen, John J. Lambourne, Biola M. Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M. Rosa, Ana R. Tomé, Heather Elding, Johanna P. van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M. Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A. Choudry, Laura Clarke, Paul Flicek, Stephen F. Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M. Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J. Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W. Wingett, Joost H. Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J. Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G. Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S. Butterworth, Johan W. Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H. Ouwehand, William J. Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and p
Externí odkaz:
https://doaj.org/article/2c4a1a97d70840748bc7d87203e84d18
Autor:
Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R. Davies, Jonathan Cairns, Natasha A. Karp
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
The high attrition rate of preclinical agents entering oncology clinical trials has been associated with poor understanding of the heterogeneous patient response, arising from limitations in the preclinical pipeline with cancer models. Patient-derive
Externí odkaz:
https://doaj.org/article/fbe31529bc76498fa1d09b256d8e05d0
Autor:
Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Publikováno v:
eLife, Vol 6 (2017)
Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re
Externí odkaz:
https://doaj.org/article/6b57a130ecbc478aaa570feb12bd03e6