Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonathan, Baell"'
Publikováno v:
ACS Omega, Vol 9, Iss 35, Pp 37170-37182 (2024)
Externí odkaz:
https://doaj.org/article/d144b398a3054ae2ba43de1e5e05191d
Autor:
Heena Doshi, Katrin Spengler, Amod Godbole, Yi Sing Gee, Jonathan Baell, Jonathan S. Oakhill, Andreas Henke, Regine Heller
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may
Externí odkaz:
https://doaj.org/article/9cbb143a3735452499080643bf1bfa2d
Autor:
Victoria Y. Ling, Jasmin Straube, William Godfrey, Rohit Haldar, Yashaswini Janardhanan, Leanne Cooper, Claudia Bruedigam, Emily Cooper, Paniz Tavakoli Shirazi, Sebastien Jacquelin, Siok-Keen Tey, Jonathan Baell, Fei Huang, Jianwen Jin, Yichao Zhao, Lars Bullinger, Megan J. Bywater, Steven W. Lane
Publikováno v:
Leukemia. 37:143-153
Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal evolution, has a dismal prognosis. A genome-wide CRISPR knockout screen investigating resistance to doxorubicin and cytarabine (Dox/AraC) in human AML cell lines identif
Autor:
Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V. Koehler, Gillian M. Fisher, Katherine T. Andrews, Benoît Laleu, Michael J. Palmer, Jeremy N. Burrows, Timothy N. C. Wells, Qingmin Wang, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Background In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber’s pole worm), one of the most pathogenic parasites of ruminants
Externí odkaz:
https://doaj.org/article/23c9a23e634d4f5fa18d8f7b336a309d
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1870:119488
Autor:
Nicole McNamara, Eleanor Saunders, Swapna Varghese, Rebecca Zheng, Kaylene Simpson, Devika M. Varma, Monica M. Johnson, M Shamim Hasan Zahid, Eric M. Bachelder, Kristy M. Ainslie, Joo Hwan No, Dahae Koh, David Shum, Nirmal Das, Binita Patra, Jayasree Roy, Arindam Talukdar, Dipyman Ganguly, Malcolm McConville, Jonathan Baell
Publikováno v:
European journal of medicinal chemistry. 240
Visceral leishmaniasis is a potentially fatal disease caused by the parasitic protists, Leishmania donovani and L. infantum. Current treatments remain unsuitable due to cost, the need for hospitalization, variable efficacy against different species,
Autor:
Bin Fang, Lin Li, Bo Peng, Jonathan Baell, Wei Huang, Hua Bai, Nicolas H. Voelcker, Yufei Xue
Publikováno v:
Chemical Society reviews. 50(8)
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention owing to their capability of achieving exquisite control over drug release via the exposure to specific stimuli. Central to the construction of such systems is the
Autor:
Yufei Xue, Hua Bai, Bo Peng, Terence Tieu, Jiamin Jiang, Shiping Hao, Panpan Li, Mark Richardson, Jonathan Baell, Helmut Thissen, Anna Cifuentes, Lin Li, Nicolas H. Voelcker
Publikováno v:
Advanced Healthcare Materials. 11:2200076
Porous silicon nanoparticles (pSiNPs) are widely utilized as drug carriers due to their excellent biocompatibility, large surface area, and versatile surface chemistry. However, the dispersion in pore size and biodegradability of pSiNPs arguably have
Autor:
Yaqing, Jiao, Sarah, Preston, Andreas, Hofmann, Aya, Taki, Jonathan, Baell, Bill C H, Chang, Abdul, Jabbar, Robin B, Gasser
Publikováno v:
Advances in parasitology. 108
Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide. Anthelmintic treatment is central to controlling these worms, but widespread resistance to most of the commercially available anthelmintics for veterinar
Autor:
Sarah, Preston, Pasi K, Korhonen, Laurent, Mouchiroud, Matteo, Cornaglia, Sean L, McGee, Neil D, Young, Rohan A, Davis, Simon, Crawford, Cameron, Nowell, Brendan R E, Ansell, Gillian M, Fisher, Katherine T, Andrews, Bill C H, Chang, Martin A M, Gijs, Paul W, Sternberg, Johan, Auwerx, Jonathan, Baell, Andreas, Hofmann, Abdul, Jabbar, Robin B, Gasser
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(10)
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selecti