Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jonatan J Thompson"'
Publikováno v:
eLife, Vol 9 (2020)
The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with b
Externí odkaz:
https://doaj.org/article/ca2039035fc8474bb0ce556f7c403cfd
Autor:
Rikard G. Fred, Julie Steen Pedersen, Jonatan J. Thompson, Julie Lee, Pascal N. Timshel, Stefan Stender, Marte Opseth Rygg, Lise Lotte Gluud, Viggo Bjerregaard Kristiansen, Flemming Bendtsen, Torben Hansen, Tune H. Pers
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The aim of this study is to characterize cell type-specific transcriptional signatures in non-alcoholic steatohepatitis (NASH) to improve our understanding of the disease. We performed single-cell RNA sequencing on liver biopsies from 10 pat
Externí odkaz:
https://doaj.org/article/fc2af34fca4b4792bd3f12cb3c30709a
Autor:
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, pred
Externí odkaz:
https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
Autor:
Cecilie Hundahl, Petra Kotzbeck, Hayley B. Burm, Søren H. Christiansen, Lola Torz, Aske W. Helge, Martin P. Madsen, Cecilia Ratner, Annette K. Serup, Jonatan J. Thompson, Thomas O. Eichmann, Tune H. Pers, David P.D. Woldbye, Daniele Piomelli, Bente Kiens, Rudolf Zechner, Louise J. Skov, Birgitte Holst
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101174- (2021)
Objective: The goal of this study was to investigate the importance of central hormone-sensitive lipase (HSL) expression in the regulation of food intake and body weight in mice to clarify whether intracellular lipolysis in the mammalian hypothalamus
Externí odkaz:
https://doaj.org/article/b4e606e56133422d9a7ea2b947c8d458
Autor:
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19869-5.
Externí odkaz:
https://doaj.org/article/c738b51898ee471abdbbcfbf08df9c18
Publikováno v:
eLife
eLife, Vol 9 (2020)
Timshel, P N, Thompson, J J & Pers, T H 2020, ' Genetic mapping of etiologic brain cell types for obesity ', eLife, vol. 9, 55851 . https://doi.org/10.7554/eLife.55851
eLife, Vol 9 (2020)
Timshel, P N, Thompson, J J & Pers, T H 2020, ' Genetic mapping of etiologic brain cell types for obesity ', eLife, vol. 9, 55851 . https://doi.org/10.7554/eLife.55851
The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee961fbcf704f32cf69ce65f3b524c6
https://doi.org/10.1530/ey.18.11.7
https://doi.org/10.1530/ey.18.11.7
Autor:
Vicente Herranz-Pérez, Camdin M. Bennett, Burak Kutlu, Zaman Mirzadeh, Thomas H. Meek, Karl J. Kaiyala, Gregory J. Morton, Tune H. Pers, Kristoffer L. Egerod, Chelsea L. Faber, Jarrad M. Scarlett, Cecilia Ratner, Birgitte Rahbek Kornum, Rasmus Jorgensen, Dylan M. Rausch, Anna Secher, Jenny M. Brown, Kevin L. Grove, Birgitte Holst, Kenjiro Muta, Jonatan J Thompson, Charles Pyke, Michael W. Schwartz, José Manuel García-Verdugo, Marie A. Bentsen, Kimberly M. Alonge, Yu Zhang, Thomas Sparsø, Arian F. Baquero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Bentsen, M A, Rausch, D M, Mirzadeh, Z, Muta, K, Scarlett, J M, Brown, J M, Herranz-Pérez, V, Baquero, A F, Thompson, J, Alonge, K M, Faber, C L, Kaiyala, K J, Bennett, C, Pyke, C, Ratner, C, Egerod, K L, Holst, B, Meek, T H, Kutlu, B, Zhang, Y, Sparso, T, Grove, K L, Morton, G J, Kornum, B R, García-Verdugo, J M, Secher, A, Jorgensen, R, Schwartz, M W & Pers, T H 2020, ' Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission ', Nature Communications, vol. 11, no. 1, 4458 . https://doi.org/10.1038/s41467-020-17720-5
Nature Communications
Repositori Universitat Jaume I
Universitat Jaume I
Bentsen, M A, Rausch, D M, Mirzadeh, Z, Muta, K, Scarlett, J M, Brown, J M, Herranz-Pérez, V, Baquero, A F, Thompson, J, Alonge, K M, Faber, C L, Kaiyala, K J, Bennett, C, Pyke, C, Ratner, C, Egerod, K L, Holst, B, Meek, T H, Kutlu, B, Zhang, Y, Sparso, T, Grove, K L, Morton, G J, Kornum, B R, García-Verdugo, J M, Secher, A, Jorgensen, R, Schwartz, M W & Pers, T H 2020, ' Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission ', Nature Communications, vol. 11, no. 1, 4458 . https://doi.org/10.1038/s41467-020-17720-5
Nature Communications
Repositori Universitat Jaume I
Universitat Jaume I
In rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1), and the mediobasal hypothalamus (MBH) was recently implicated as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9242d0409dd94663e87151f0f8c85681
Autor:
Pi Camilla Poulsen, Sunil Jit R. J. Logantha, Tune H. Pers, Martin J. Humphries, Jesper V. Olsen, Nora Linscheid, Jonatan J Thompson, Maren Schrölkamp, Ashraf Kitmitto, Henggui Zhang, Alicia Lundby, Gina L. J. Galli, Shanzhuo Zhang, Kristoffer L. Egerod, Mark R. Boyett
Publikováno v:
Nature Communications
Linscheid, N, Logantha, S J R J, Poulsen, P C, Zhang, S, Schrölkamp, M, Egerod, K L, Thompson, J J, Kitmitto, A, Galli, G, Humphries, M J, Zhang, H, Pers, T H, Olsen, J V, Boyett, M & Lundby, A 2019, ' Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking ', Nature Communications, vol. 10, no. 1, 2889 . https://doi.org/10.1038/s41467-019-10709-9
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Linscheid, N, Logantha, S J R J, Poulsen, C, Zhang, S, Schrolkamp, M, Egerod, K L, Thompson, J J, Kitmitto, A, Galli, G, Humphries, M J, Zhang, H, Pers, T H, Olsen, J V, Boyett, M & Lundby, A 2019, ' Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking ', Nature Communications, vol. 10, 2889 . https://doi.org/10.1038/s41467-019-10709-9
Linscheid, N, Logantha, S J R J, Poulsen, P C, Zhang, S, Schrölkamp, M, Egerod, K L, Thompson, J J, Kitmitto, A, Galli, G, Humphries, M J, Zhang, H, Pers, T H, Olsen, J V, Boyett, M & Lundby, A 2019, ' Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking ', Nature Communications, vol. 10, no. 1, 2889 . https://doi.org/10.1038/s41467-019-10709-9
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Linscheid, N, Logantha, S J R J, Poulsen, C, Zhang, S, Schrolkamp, M, Egerod, K L, Thompson, J J, Kitmitto, A, Galli, G, Humphries, M J, Zhang, H, Pers, T H, Olsen, J V, Boyett, M & Lundby, A 2019, ' Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking ', Nature Communications, vol. 10, 2889 . https://doi.org/10.1038/s41467-019-10709-9
The sinus node is a collection of highly specialised cells constituting the heart’s pacemaker. The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution mass spectrometry, we here quantify >7,000 proteins from sinus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78ae2dd57b9994cd8d7804487e2d060
http://europepmc.org/articles/PMC6599035
http://europepmc.org/articles/PMC6599035
Autor:
Jean-François Perrier, Tune H. Pers, Morten Hedegaard, Birgitte Holst, Cord Brakebusch, Cecilia Ratner, Louise J. Skov, Hayley B. Burm, Jonatan J Thompson, Louise S. Dalbøge, Nikolaj W. Hansen, Kristoffer L. Egerod
Publikováno v:
Journal of neuroendocrinology. 31(7)
Dopamine-producing tyrosine hydroxylase (TH) neurones in the hypothalamic arcuate nucleus (ARC) have recently been shown to be involved in ghrelin signalling and body weight homeostasis. In the present study, we investigate the role of the intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a3eabcbe806657b854a50d390edc71
https://pubmed.ncbi.nlm.nih.gov/31237372
https://pubmed.ncbi.nlm.nih.gov/31237372