Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonas Zierer"'
Autor:
Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Biomarkers that predict mortality are of interest for clinical as well as research applications. Here, the authors analyze metabolomics data from 44,168 individuals and identify key metabolites independently associated with all-cause mortality risk.
Externí odkaz:
https://doaj.org/article/6923daf567204a5eb33b751c0974e159
Autor:
Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances M. K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector, Claire J. Steves
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The human gut microbiome has been associated with many health factors, but variability between studies limits exploration of these effects. Here, Jackson et al. analyse gut microbiota associations for 38 common diseases and 51 medications within >270
Externí odkaz:
https://doaj.org/article/d4eeca0813a74f6d87a60ada7791825c
Autor:
Matthew A. Jackson, Marc Jan Bonder, Zhana Kuncheva, Jonas Zierer, Jingyuan Fu, Alexander Kurilshikov, Cisca Wijmenga, Alexandra Zhernakova, Jordana T. Bell, Tim D. Spector, Claire J. Steves
Publikováno v:
PeerJ, Vol 6, p e4303 (2018)
Microbes in the gut microbiome form sub-communities based on shared niche specialisations and specific interactions between individual taxa. The inter-microbial relationships that define these communities can be inferred from the co-occurrence of tax
Externí odkaz:
https://doaj.org/article/feef1f1dc4d94435ae3303fd12c65552
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e84596 (2014)
Different ensemble voting approaches have been successfully applied for reverse-engineering of gene regulatory networks. They are based on the assumption that a good approximation of true network structure can be derived by considering the frequencie
Externí odkaz:
https://doaj.org/article/2bb6b9cf7840449cab6f10f6be846ffb
Autor:
Matthias Arnold, Daniel P. Gomari, Mustafa Buyukozkan, Kelsey Chetnik, Zeyu Wang, Jan Krumsiek, Jonas Zierer, Elisa Benedetti, Karsten Suhre, Richa Batra, Annalise Schweickart
Publikováno v:
Bioinformatics
This article presents maplet, an open-source R package for the creation of highly customizable, fully reproducible statistical pipelines for metabolomics data analysis. It builds on the SummarizedExperiment data structure to create a centralized pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647f31206d207867e46585d9eccb4cfe
http://europepmc.org/articles/PMC8796365
http://europepmc.org/articles/PMC8796365
Autor:
Tõnu Esko, Cristina Menni, Kristen Fortney, Eric K. Morgen, Maria Luisa Matey-Hernandez, Andrew Fu Wah Ho, Jonah Sinick, Jonas Zierer, Krista Fischer
Publikováno v:
Aging (Albany NY)
Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d54c90253ae271d90eeb72a69b86bb
http://europepmc.org/articles/PMC6781977
http://europepmc.org/articles/PMC6781977
Autor:
Anna Halama, Johannes Graumann, Thozhukat Sathyapalan, Jonas Zierer, Stephen L. Atkin, Karsten Suhre, Hassan Kahal, Aditya M. Bhagwat
Publikováno v:
Diabetes, Obesity and Metabolism. 21:909-919
Aims To determine the biochemical changes that underlie hypoglycaemia in a healthy control group and in people with type 2 diabetes (T2D). Materials and methods We report a hypoglycaemic clamp study in seven healthy controls and 10 people with T2D. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e7db70ae7374a55b72106bb21d9cc3
https://doi.org/10.1111/dom.13602
https://doi.org/10.1111/dom.13602
Autor:
Suzanne Brewerton, Lining Guo, Amalio Telenti, Nicholas J. Schork, Tao Long, Yaron Turpaz, J. Craig Venter, Jonas Zierer, Hung-Chun Yu, Cristina Menni, Chad Garner, Michael A. Hicks, Helen Messier, Anne M. Evans, C. Thomas Caskey, Massimo Mangino, William H. Biggs, Kerrin S. Small, Brad A. Perkins, Tim D. Spector, Luke A. D. Miller, Ewen F. Kirkness
Publikováno v:
Nature Genetics. 49:568-578
Genetic factors modifying the blood metabolome have been investigated through genome-wide association studies (GWAS) of common genetic variants and through exome sequencing. We conducted a whole-genome sequencing study of common, low-frequency and ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04645a0a5924f697f264223698571667
https://doi.org/10.1038/ng.3809
https://doi.org/10.1038/ng.3809
Publikováno v:
Menni, C, Zierer, J, Valdes, A M & Spector, T D 2017, ' Mixing omics : combining genetics and metabolomics to study rheumatic diseases ', Nature Reviews Rheumatology, pp. 174-181 . https://doi.org/10.1038/nrrheum.2017.5
Metabolomics is an exciting field in systems biology that provides a direct readout of the biochemical activities taking place within an individual at a particular point in time. Metabolite levels are influenced by many factors, including disease sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81337475d63caa3f4544699ecb8e647
https://doi.org/10.1038/nrrheum.2017.5
https://doi.org/10.1038/nrrheum.2017.5
Autor:
Cristina Menni, Nele Friedrich, Robert P. Mohney, Maik Pietzner, Linsay McCallum, Sandosh Padmanabhan, Massimo Mangino, Tim D. Spector, Jonas Zierer, Karsten Suhre, Alisha Aman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Menni, C, McCallum, L, Pietzner, M, Zierer, J B, Aman, A, Suhre, K, Mohney, R, Mangino, M, Friedrich, N, Spector, T D & Padmanabhan, S 2019, ' Metabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns ', Scientific Reports, vol. 9, no. 1, 15088 . https://doi.org/10.1038/s41598-019-51492-3
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Menni, C, McCallum, L, Pietzner, M, Zierer, J B, Aman, A, Suhre, K, Mohney, R, Mangino, M, Friedrich, N, Spector, T D & Padmanabhan, S 2019, ' Metabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns ', Scientific Reports, vol. 9, no. 1, 15088 . https://doi.org/10.1038/s41598-019-51492-3
Electrolytes have a crucial role in maintaining health and their serum levels are homeostatically maintained within a narrow range by multiple pathways involving the kidneys. Here we use metabolomics profiling (592 fasting serum metabolites) to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa9f8224dacf66e8c9a78fff5b2799
https://eprints.gla.ac.uk/202499/1/202499.pdf
https://eprints.gla.ac.uk/202499/1/202499.pdf
