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Akademický článek

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Autor: Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Parasitic diseases, particularly malaria (caused by Plasmodium falciparum) and theileriosis (caused by Theileria spp.), profoundly impact global health and the socioeconomic well-being of lower-income countries. Despite recent advances, iden

Externí odkaz: https://doaj.org/article/6b4b2ca83d7b4ebaa7f6f50164e555c9

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Akademický článek

Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

Autor: Lukas Muri, Ngoc Dung Le, Jonas Zemp, Denis Grandgirard, Stephen L. Leib

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive infla

Externí odkaz: https://doaj.org/article/41f13a51d7c3461e8599a33658a311ee

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Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

Autor: Jonas Zemp, Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Stephen L. Leib

Publikováno v: Muri, Lukas Kilian; Le, Ngoc Dung; Zemp, Jonas; Grandgirard, Denis; Leib, Stephen L. (2019). Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis. Journal of neuroinflammation, 16(1), p. 156. BioMed Central 10.1186/s12974-019-1549-6
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Journal of Neuroinflammation

Background Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c04d854827debb54431d3399f1f957c
https://boris.unibe.ch/133327/2/document.pdf

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Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis

Autor: Michael Perny, Jonas Zemp, Lukas Muri, Stephen L. Leib, Denis Grandgirard

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities. An excessive inflammatory reaction drives th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758f41cf7e41eb83cce46b3d2ad3f808
https://doi.org/10.1128/aac.00220-19

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