Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jonas Waider"'
Autor:
Jann F Kolter, Markus F Hildenbrand, Sandy Popp, Stephan Nauroth, Julian Bankmann, Lisa Rother, Jonas Waider, Jürgen Deckert, Esther Asan, Peter M Jakob, Klaus-Peter Lesch, Angelika Schmitt-Böhrer
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247311 (2021)
The serotonin transporter (5-HTT) is a key molecule of serotoninergic neurotransmission and target of many anxiolytics and antidepressants. In humans, 5-HTT gene variants resulting in lower expression levels are associated with behavioral traits of a
Externí odkaz:
https://doaj.org/article/46be1085dfe14b58aaf588564f7ba889
Autor:
Charline Jansch, Katharina Günther, Jonas Waider, Georg C. Ziegler, Andrea Forero, Sina Kollert, Evgeniy Svirin, Dirk Pühringer, Chee Keong Kwok, Reinhard Ullmann, Anna Maierhofer, Julia Flunkert, Thomas Haaf, Frank Edenhofer, Klaus-Peter Lesch
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 136-140 (2018)
Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibrob
Externí odkaz:
https://doaj.org/article/1c21998df05b4e85b4bdbcfa9a227207
Autor:
Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer’s disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD and an instigator o
Externí odkaz:
https://doaj.org/article/6646f32c41c544b8812979343cb20ff4
Autor:
Magdalena T. Weidner, Roy Lardenoije, Lars Eijssen, Floriana Mogavero, Lilian P. M. T. De Groodt, Sandy Popp, Rupert Palme, Konrad U. Förstner, Tatyana Strekalova, Harry W. M. Steinbusch, Angelika G. Schmitt-Böhrer, Jeffrey C. Glennon, Jonas Waider, Daniel L. A. van den Hove, Klaus-Peter Lesch
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of 5-HT synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. Here,
Externí odkaz:
https://doaj.org/article/e9bfdfc3a3f543148df4c4b9e9207fcb
Autor:
Jonas Waider, Sandy Popp, Boris Mlinar, Alberto Montalbano, Francesco Bonfiglio, Benjamin Aboagye, Elisabeth Thuy, Raphael Kern, Christopher Thiel, Naozumi Araragi, Evgeniy Svirin, Angelika G. Schmitt-Böhrer, Renato Corradetti, Christopher A. Lowry, Klaus-Peter Lesch
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood. Here, we invest
Externí odkaz:
https://doaj.org/article/f15dc4e533db4c8ab1a0c1e1a7ec4a7a
Autor:
Andrea Forero, Olga Rivero, Sina Wäldchen, Hsing-Ping Ku, Dominik P. Kiser, Yvonne Gärtner, Laura S. Pennington, Jonas Waider, Patricia Gaspar, Charline Jansch, Frank Edenhofer, Thérèse J. Resink, Robert Blum, Markus Sauer, Klaus-Peter Lesch
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Background: During early prenatal stages of brain development, serotonin (5-HT)-specific neurons migrate through somal translocation to form the raphe nuclei and subsequently begin to project to their target regions. The rostral cluster of cells, com
Externí odkaz:
https://doaj.org/article/03b246aff9ba4670b540acf15d9bfd86
Autor:
Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesch
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43157 (2012)
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in developmental processes. Increasing evidence links 5-HT signaling alterat
Externí odkaz:
https://doaj.org/article/18c3a44961234527815c1900a4624007
Autor:
Allan V. Kalueff, Natalia Bazhenova, Ekaterina Veniaminova, Daniel C. Anthony, Klaus-Peter Lesch, Anna Gorlova, Andrey Proshin, G. Ortega, Tatyana Strekalova, Jonas Waider
Publikováno v:
Journal of Affective Disorders, 272, 440-451. Elsevier
Journal of Affective Disorders
Journal of Affective Disorders
Background: The contribution of gene-environment interactions that lead to excessive aggression is poorly understood. Environmental stressors and mutations of the gene encoding tryptophan hydroxylase-2 (TPH2) are known to influence aggression. For ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a6bc81796f91ca5d7de4bc08360e3a
https://doi.org/10.1016/j.jad.2020.04.014
https://doi.org/10.1016/j.jad.2020.04.014
Autor:
Christian Ulrich von Linstow, Jonas Waider, Marianne Skov-Skov Bergh, Marco Anzalone, Cecilie Madsen, Aina Battle Nicolau, Martin Wirenfeldt, Klaus-Peter Lesch, Bente Finsen
Publikováno v:
Journal of Alzheimer's Disease, 85(3), 1283-1300. IOS Press
von Linstow, C U, Waider, J, Bergh, M S-S, Anzalone, M, Madsen, C, Nicolau, A B, Wirenfeldt, M, Lesch, K-P & Finsen, B 2022, ' The Combined Effects of Amyloidosis and Serotonin Deficiency by Tryptophan Hydroxylase-2 Knockout Impacts Viability of the APP/PS1 Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's disease : JAD, vol. 85, no. 3, pp. 1283-1300 . https://doi.org/10.3233/JAD-210581
von Linstow, C U, Waider, J, Bergh, M S-S, Anzalone, M, Madsen, C, Nicolau, A B, Wirenfeldt, M, Lesch, K-P & Finsen, B 2022, ' The Combined Effects of Amyloidosis and Serotonin Deficiency by Tryptophan Hydroxylase-2 Knockout Impacts Viability of the APP/PS1 Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's disease : JAD, vol. 85, no. 3, pp. 1283-1300 . https://doi.org/10.3233/JAD-210581
BACKGROUND: A decline of brain serotonin (5-HT) is held responsible for the changes in mood that can be observed in Alzheimer's disease (AD). However, 5-HT'ergic signaling is also suggested to reduce the production of pathogenic amyloid-4β (Aβ).OBJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f964555ea0b5be1746bf6070efa92
https://cris.maastrichtuniversity.nl/en/publications/78e2eb6e-fc0f-4a3a-8760-3f8439465871
https://cris.maastrichtuniversity.nl/en/publications/78e2eb6e-fc0f-4a3a-8760-3f8439465871
Autor:
Charline Jansch, Frank Edenhofer, Maria Rosaria Vitale, Katharina Günther, Johanna E. M. Zöller, Markus Sauer, Klaus-Peter Lesch, Andrea Forero, Evgeniy Svirin, Erhard Wischmeyer, Jonas Waider, Sina Wäldchen, Sina Gredy, Georg C. Ziegler
Publikováno v:
Journal of Neural Transmission, 128(2), 225-241. Springer
Journal of Neural Transmission
Journal of Neural Transmission
Human induced pluripotent stem cells (hiPSCs) have revolutionized the generation of experimental disease models, but the development of protocols for the differentiation of functionally active neuronal subtypes with defined specification is still in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cccf281f11c9e9a8732c1e96cb4787
https://cris.maastrichtuniversity.nl/en/publications/08169da1-2c72-46ec-92e5-5f4d0fb445fe
https://cris.maastrichtuniversity.nl/en/publications/08169da1-2c72-46ec-92e5-5f4d0fb445fe