Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Jonas T Treebak"'
Autor:
Christian Frøsig, Thomas E Jensen, Jacob Jeppesen, Christian Pehmøller, Jonas T Treebak, Stine J Maarbjerg, Jonas M Kristensen, Lykke Sylow, Thomas J Alsted, Peter Schjerling, Bente Kiens, Jørgen F P Wojtaszewski, Erik A Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62338 (2013)
The 5'-AMP-activated protein kinase (AMPK) is considered "a metabolic master-switch" in skeletal muscle reducing ATP- consuming processes whilst stimulating ATP regeneration. Within recent years, AMPK has also been proposed as a potential target to a
Externí odkaz:
https://doaj.org/article/dc98e45ee71b43d38484f0835f31be3d
Autor:
Sabina Chubanava, Jonas T. Treebak
Publikováno v:
Experimental Gerontology, Vol 173, Iss , Pp 112109- (2023)
Skeletal muscle is a tissue integral to general health. Due to its high abundance and oxidative capacity, its metabolism is intimately linked to whole-body physiology. In the elderly population, mobility correlates positively with life expectancy and
Externí odkaz:
https://doaj.org/article/2ede40c9b0a4404282ac1147f3d98c1f
Autor:
Stephen P. Ashcroft, Sara L. Jepsen, Amy M. Ehrlich, Jonas T. Treebak, Jens J. Holst, Juleen R. Zierath
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101985- (2023)
Summary: The tissue-specific release and uptake of metabolites in response to exercise is incompletely understood. Here, we detail a protocol to assess arteriovenous differences across the liver and hindlimb muscles in response to treadmill exercise
Externí odkaz:
https://doaj.org/article/983f8948e2224543bcb818ddb6aa3792
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101581- (2022)
Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may progress to cirrhosis and liver cancer. NAFLD is rapidly becoming a global h
Externí odkaz:
https://doaj.org/article/d7ece3f1e5964cf28abefb81c76d1cfa
Autor:
Jonas Brorson Jensen, Ole L. Dollerup, Andreas B. Møller, Tine B. Billeskov, Emilie Dalbram, Sabina Chubanava, Mads V. Damgaard, Ryan W. Dellinger, Kajetan Trošt, Thomas Moritz, Steffen Ringgaard, Niels Møller, Jonas T. Treebak, Jean Farup, Niels Jessen
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide riboside (NR) and pteros
Externí odkaz:
https://doaj.org/article/614077a593674c7a8b1130bb651c388e
Autor:
Mads V. Damgaard, Jonas T. Treebak
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101515- (2022)
Summary: This protocol presents a variation on the 2-ΔΔCt technique for qPCR analysis. Our approach requires the inclusion of a standard curve on each qPCR plate, and like the 2-ΔΔCt technique, is dependent on the stability of housekeeping gene e
Externí odkaz:
https://doaj.org/article/cfca73fcc1f441e5ab3919eecca63c82
Autor:
Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antônio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss, Maria Cristina Foss-Freitas
Publikováno v:
Nutrients, Vol 14, Iss 13, p 2670 (2022)
Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive whether the benefits of DR in humans are mediated by calorie or nutrient restriction. This
Externí odkaz:
https://doaj.org/article/d68d5ac9e6164bfb8618a5e8ccfc86ba
Autor:
Karen Nørgaard Nielsen, Julia Peics, Tao Ma, Iuliia Karavaeva, Morten Dall, Sabina Chubanava, Astrid L. Basse, Oksana Dmytriyeva, Jonas T. Treebak, Zachary Gerhart-Hines
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 178-188 (2018)
Objective: The ability of adipose tissue to expand and contract in response to fluctuations in nutrient availability is essential for the maintenance of whole-body metabolic homeostasis. Given the nutrient scarcity that mammals faced for millions of
Externí odkaz:
https://doaj.org/article/fedae59f6f7b4c6a8086f0c57ba2e0f1
Autor:
Hao Shi, Alexander Munk, Thomas S. Nielsen, Morgan R. Daughtry, Louise Larsson, Shize Li, Kasper F. Høyer, Hannah W. Geisler, Karolina Sulek, Rasmus Kjøbsted, Taylor Fisher, Marianne M. Andersen, Zhengxing Shen, Ulrik K. Hansen, Eric M. England, Zhiyong Cheng, Kurt Højlund, Jørgen F.P. Wojtaszewski, Xiaoyong Yang, Matthew W. Hulver, Richard F. Helm, Jonas T. Treebak, David E. Gerrard
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 160-177 (2018)
Objective: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of O-GlcNAc transferase (OGT), the
Externí odkaz:
https://doaj.org/article/261b3cbf836f43468337bc9950698585
Autor:
A. Augusto Peluso, Agnete T. Lundgaard, Parizad Babaei, Felippe Mousovich-Neto, Andréa L. Rocha, Mads V. Damgaard, Emilie G. Bak, Thiyagarajan Gnanasekaran, Ole L. Dollerup, Samuel A. J. Trammell, Thomas S. Nielsen, Timo Kern, Caroline B. Abild, Karolina Sulek, Tao Ma, Zach Gerhart-Hines, Matthew P. Gillum, Manimozhiyan Arumugam, Cathrine Ørskov, Douglas McCloskey, Niels Jessen, Markus J. Herrgård, Marcelo A. S. Mori, Jonas T. Treebak
Publikováno v:
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, 7 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4
The gut microbiota impacts systemic levels of multiple metabolites including NAD+ precursors through diverse pathways. Nicotinamide riboside (NR) is an NAD+ precursor capable of regulating mammalian cellular metabolism. Some bacterial families expres