NOX2 deficiency exacerbates diet-induced obesity and impairs molecular training adaptations in skeletal muscle

Autor: Carlos Henriquez-Olguin, Roberto Meneses-Valdes, Steffen H. Raun, Samantha Gallero, Jonas R. Knudsen, Zhencheng Li, Jingwen Li, Lykke Sylow, Enrique Jaimovich, Thomas E. Jensen

Publikováno v: Redox Biology, Vol 65, Iss , Pp 102842- (2023)

The production of reactive oxygen species (ROS) by NADPH oxidase (NOX) 2 has been linked to both insulin resistance and exercise training adaptations in skeletal muscle. This study explores the previously unexamined role of NOX2 in the interplay betw

Externí odkaz: https://doaj.org/article/cc0068ea279141328c3937b767f06dc4

Gene deletion of γ‐actin impairs insulin‐stimulated skeletal muscle glucose uptake in growing mice but not in mature adult mice

Autor: Jonas R. Knudsen, Agnete B. Madsen, Zhencheng Li, Nicoline R. Andersen, Peter Schjerling, Thomas E. Jensen

Publikováno v: Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)

Abstract The cortical cytoskeleton, consisting of the cytoplasmic actin isoforms β and/or γ‐actin, has been implicated in insulin‐stimulated GLUT4 translocation and glucose uptake in muscle and adipose cell culture. Furthermore, transgenic inhi

Externí odkaz: https://doaj.org/article/aa1c64e156df44978a3be74a2fc474dc

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Autor: Carlos Henríquez-Olguin, Jonas R. Knudsen, Steffen H. Raun, Zhencheng Li, Emilie Dalbram, Jonas T. Treebak, Lykke Sylow, Rikard Holmdahl, Erik A. Richter, Enrique Jaimovich, Thomas E. Jensen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and

Externí odkaz: https://doaj.org/article/a635b493f521447c82852adb296d2252

The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport

Autor: Lisbeth L. V. Møller, Ida L. Nielsen, Jonas R. Knudsen, Nicoline R. Andersen, Thomas E. Jensen, Lykke Sylow, Erik A. Richter

Publikováno v: Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)

Abstract Aim Muscle contraction stimulates skeletal muscle glucose transport. Since it occurs independently of insulin, it is an important alternative pathway to increase glucose transport in insulin‐resistant states, but the intracellular signalin

Externí odkaz: https://doaj.org/article/696e4e5987b24d4a81beb27350263efa

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Autor: Jonas R Knudsen, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen

Publikováno v: Knudsen, J R, Persson, K W, Henriquez-Olguin, C, Li, Z, Di Leo, N, Hesselager, S A, Raun, S H, Hingst, J R, Trouillon, R, Wohlwend, M, Wojtaszewski, J, Gijs, M A M & Jensen, T E 2023, ' Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle ', eLife, vol. 12, e83338 . https://doi.org/10.7554/eLife.83338

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6115eafd90dee4ed5abd5779cc6e51a
https://doi.org/10.7554/elife.83338