Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonas Mariën"'
Autor:
Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Early clinical results of two tau tracers, [ 18 F]T808 and [ 18 F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire compara
Externí odkaz:
https://doaj.org/article/614086a8936e4b7ebe4f365af2458065
Autor:
Hartmuth C. Kolb, Stijn Wuyts, Cindy Wintmolders, Leenaerts Joseph Elisabeth, Astrid Bottelbergs, Lieven Declercq, Fengbin Song, Paula te Riele, Chunfang A. Xia, Laura Iturrino, Frederik J. R. Rombouts, José-Ignacio Andrés, Diederik Moechars, Jonas Mariën, Lu Chen, Guy Bormans, Rik Vandenberghe
Publikováno v:
Journal of Medicinal Chemistry. 62:2974-2987
In Alzheimer’s disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure–activity relationship exploration around an
Autor:
Alberto Carpinteiro Soares, Jonas Mariën, Edward B. Lee, John Q. Trojanowski, Charlotte Delay, Andreia Ferreira, Dieder Moechars, Louis De Muynck, Wim Annaert
Publikováno v:
The Journal of Biological Chemistry
Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsyna
Autor:
José Ignacio Andrés, Michel Koole, Diederik Moechars, Katleen Fierens, Xavier Langlois, Frederik J. R. Rombouts, Koen Van Laere, Guy Bormans, Lieven Declercq, Jonas Mariën, Rik Vandenberghe, Thomas Tousseyn, Gregor James Macdonald, Wim Vanduffel, Mark E. Schmidt, Alfons Verbruggen
Publikováno v:
Journal of Nuclear Medicine. 58:975-981
In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥500×) in vitro selectivity for tau over β-amyloid, in comparison with the benchmark comp
Autor:
Mark E. Schmidt, Rhys Salter, Cindy Wintmolders, Nigel Austin, Vladimir Chupakhin, Gregor James Macdonald, Astrid Bottelbergs, Paula te Riele, Lu Chen, Katleen Fierens, Diederik Moechars, Andrés A. Trabanco, José-Ignacio Andrés, José Manuel Alonso, Jonas Mariën, Erna Cleiren, Martinez Lamenca Carolina, Frederik J. R. Rombouts, Manuela Ariza, Leenaerts Joseph Elisabeth, Xavier Langlois, Wei Zhang, Alberto Fontana
Publikováno v:
Journal of Medicinal Chemistry. 60:1272-1291
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD a
Autor:
Frederik J R, Rombouts, Lieven, Declercq, José-Ignacio, Andrés, Astrid, Bottelbergs, Lu, Chen, Laura, Iturrino, Joseph E, Leenaerts, Jonas, Mariën, Fengbin, Song, Cindy, Wintmolders, Stijn, Wuyts, Chunfang A, Xia, Paula, Te Riele, Guy, Bormans, Rik, Vandenberghe, Hartmuth, Kolb, Diederik, Moechars
Publikováno v:
Journal of medicinal chemistry. 62(6)
In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an iso
Autor:
Frederik J. R. Rombouts, Lieven Declercq, José-Ignacio Andrés, Astrid Bottelbergs, Lu Chen, Laura Iturrino, Joseph E. Leenaerts, Jonas Mariën, Fengbin Song, Cindy Wintmolders, Stijn Wuyts, Chunfang A. Xia, Paula te Riele, Guy Bormans, Rik Vandenberghe, Hartmuth Kolb, Diederik Moechars
Publikováno v:
Journal of Medicinal Chemistry. 63:1775-1775
Autor:
Lieven, Declercq, Frederik, Rombouts, Michel, Koole, Katleen, Fierens, Jonas, Mariën, Xavier, Langlois, José Ignacio, Andrés, Mark, Schmidt, Gregor, Macdonald, Diederik, Moechars, Wim, Vanduffel, Thomas, Tousseyn, Rik, Vandenberghe, Koen, Van Laere, Alfons, Verbruggen, Guy, Bormans
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(6)
In this study, we have synthesized and evaluated
Autor:
Sofie Celen, Jesús Alcázar, Manuela Ariza, Muneer Ahamed, Diederik Moechars, Alfons Verbruggen, Guy Bormans, Ignacio José Andrés, Astrid Bottelbergs, Thomas Tousseyn, Lieven Declercq, Rik Vandenberghe, Joan Lecina, Jonas Mariën, Katleen Fierens, Koen Van Laere
Publikováno v:
Molecular imaging
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire compara