Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant.

Autor: O Rickard Nilsson, Jonas Lannergård, B Paul Morgan, Gunnar Lindahl, Mattias C U Gustafsson

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81303 (2013)

Recent studies indicate that defective activity of complement factor H (FH) is associated with several human diseases, suggesting that pure FH may be used for therapy. Here, we describe a simple method to isolate human FH, based on the specific inter

Externí odkaz: https://doaj.org/article/0fe95e9916174108bbac3b6cdc3f2f44

Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus.

Autor: Jonas Lannergård, Sha Cao, Tobias Norström, Alejandro Delgado, John E Gustafson, Diarmaid Hughes

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28366 (2011)

FusE mutants are fusidic acid-resistant small colony variants (SCVs) of Staphylococcus aureus that can be selected with aminoglycosides. All FusE SCVs have mutations in rplF, encoding ribosomal protein L6. However, individual FusE mutants including s

Externí odkaz: https://doaj.org/article/7e1cb4cce526443a849529952ac51ada

The Maternal Group B Streptococcus Alpha-Like Protein Subunit Vaccine GBS-NN Targets Homotypic and Heterotypic Strains, Confers Opsonophagocytic Killing and Prevents in vitro Invasion of Human Epithelial Cells

Autor: Duojia Cao, Jenny L. Persson, Ane Lilleøre Rom, Andrzej Pawlowski, Morten Hedegaard, Jonas Lannergård, Sara Larsson, Bengt Johansson Lindbom, Geoff Kitsson, Majela Gonzalez-Miro, Per Fischer, Michael Darsley

Publikováno v: SSRN Electronic Journal.

Maternal vaccination, resulting in transfer of protective IgG across the placenta, represents a promising strategy to prevent neonatal disease caused by group B Streptococcus (GBS). The prototype vaccine GBS-NN, a fusion protein consisting of the N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d43aaed556c882d3b50707ffe4aaed
https://doi.org/10.2139/ssrn.3924602

The Hypervariable Region of Streptococcus pyogenes M Protein Escapes Antibody Attack by Antigenic Variation and Weak Immunogenicity

Autor: Mattias C. U. Gustafsson, Margaretha Stålhammar-Carlemalm, Anna Norrby-Teglund, Jonas Lannergård, Johan Waldemarsson, Gunnar Lindahl

Publikováno v: Cell Host & Microbe. 10(2):147-157

SummarySequence variation of antigenic proteins allows pathogens to evade antibody attack. The variable protein commonly includes a hypervariable region (HVR), which represents a key target for antibodies and is therefore predicted to be immunodomina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc92cf0837634179ce87440212d74427

Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein

Autor: Margaretha Stålhammar-Carlemalm, Jonas Lannergård, Mattias C. U. Gustafsson, Jenny L. Persson, Anna Norrby-Teglund, Bodil M. Kristensen, Gunnar Lindahl

Publikováno v: MicrobiologyOpen
Lannergård, J, Kristensen, B M, Gustafsson, M C U, Persson, J J, Norrby-Teglund, A, Stålhammar-Carlemalm, M & Lindahl, C G 2015, ' Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein ', MicrobiologyOpen, vol. 4, no. 5, pp. 774-789 . https://doi.org/10.1002/mbo3.278

The M protein of Streptococcus pyogenes, a major bacterial virulence factor, has an amino-terminal hypervariable region (HVR) that is a target for type-specific protective antibodies. Intriguingly, the HVR elicits a weak antibody response, indicating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac9de04112a5b7b53f933e9ba50b83b
https://pubmed.ncbi.nlm.nih.gov/26175306