Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jonas Langerud"'
Autor:
Jonas Langerud, Ina A. Eilertsen, Seyed H. Moosavi, Solveig M. K. Klokkerud, Henrik M. Reims, Ingeborg F. Backe, Merete Hektoen, Ole H. Sjo, Marine Jeanmougin, Sabine Tejpar, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Intra-tumor heterogeneity compromises the clinical value of transcriptomic classifications of colorectal cancer. We investigated the prognostic effect of transcriptomic heterogeneity and the potential for classifications less vulnerable to h
Externí odkaz:
https://doaj.org/article/d4d1453bbc3e48efb2d29292fe31b570
Autor:
Peter W. Eide, Seyed H. Moosavi, Ina A. Eilertsen, Tuva H. Brunsell, Jonas Langerud, Kaja C. G. Berg, Bård I. Røsok, Bjørn A. Bjørnbeth, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Gene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic het
Externí odkaz:
https://doaj.org/article/8094865baf5d4bffb26a44258515a35d
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-13 (2018)
Abstract Background Deleterious variants in the tumour suppressor BRCA1 are known to cause hereditary breast and ovarian cancer syndrome (HBOC). Missense variants in BRCA1 pose a challenge in clinical care, as their effect on protein functionality of
Externí odkaz:
https://doaj.org/article/75838fdb553a4de2a0d3394804b44b21
Autor:
Ragnhild A. Lothe, Anita Sveen, Bjørn Atle Bjørnbeth, Arild Nesbakken, Marianne G. Guren, Rodrigo Dienstmann, Tormod Guren, Kristoffer W. Brudvik, Hector G. Palmer, Christian H. Bergsland, Jani Saarela, Teijo Pellinen, Tuva H. Brunsell, Max Z. Totland, Bård Røsok, Jonas Langerud, Ina A. Eilertsen, Seyed H. Moosavi, Peter W. Eide, Kushtrim Kryeziu, Jarle Bruun
Purpose:Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of sensitivity to anticancer agents has not been well explored in colorectal cancer.Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c638067b84c7e740fe78cc2152fa3e5
https://doi.org/10.1158/1078-0432.c.6529418.v1
https://doi.org/10.1158/1078-0432.c.6529418.v1
Autor:
Ragnhild A. Lothe, Anita Sveen, Bjørn Atle Bjørnbeth, Arild Nesbakken, Marianne G. Guren, Rodrigo Dienstmann, Tormod Guren, Kristoffer W. Brudvik, Hector G. Palmer, Christian H. Bergsland, Jani Saarela, Teijo Pellinen, Tuva H. Brunsell, Max Z. Totland, Bård Røsok, Jonas Langerud, Ina A. Eilertsen, Seyed H. Moosavi, Peter W. Eide, Kushtrim Kryeziu, Jarle Bruun
Supplementary methods, materials and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30832e0e7e4238a5ca8bee4519f395a8
https://doi.org/10.1158/1078-0432.22476536.v1
https://doi.org/10.1158/1078-0432.22476536.v1
Autor:
Seyed H. Moosavi, Peter W. Eide, Anita Sveen, Bjørn Atle Bjørnbeth, Kaja Christine Graue Berg, Jonas Langerud, Bård I. Røsok, Tuva Høst Brunsell, Arild Nesbakken, Ina A. Eilertsen, Ragnhild A. Lothe
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Genomic Medicine
NPJ Genomic Medicine
Gene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic heterogeneit
Autor:
Jonas Langerud, Ina A. Eilertsen, Hossein Moosavi, Ingeborg F. Backe, Merete Hektoen, Marine Jeanmougin, Ole Sjo, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
Cancer Research. 83:4540-4540
Purpose: Tumor heterogeneity compromises the clinical applicability of transcriptomic subtypes of colorectal cancers (CRCs). We performed multiregional tumor sampling to map the intra-tumor heterogeneity of primary CRCs and to evaluate the prognostic
Autor:
Seyed H. Moosavi, Rodrigo Dienstmann, Max Z. Totland, Jani Saarela, Bård I. Røsok, Bjørn Atle Bjørnbeth, Christian H. Bergsland, H.G. Palmer, Jarle Bruun, Ragnhild A. Lothe, Peter W. Eide, Kristoffer Watten Brudvik, Anita Sveen, Marianne Grønlie Guren, Teijo Pellinen, Tormod Kyrre Guren, Ina A. Eilertsen, Tuva Høst Brunsell, Arild Nesbakken, Jonas Langerud, Kushtrim Kryeziu
Purpose:Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of sensitivity to anticancer agents has not been well explored in colorectal cancer.Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b4a6eb7ca33d3fc5773dc0e50c0269
http://hdl.handle.net/10138/328979
http://hdl.handle.net/10138/328979
Autor:
Guro Elisabeth Lind, Jonas Langerud, Bjørnar Tovson Bae Flatin, Rita Pinto, Marine Jeanmougin, Hege Marie Vedeld, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
International Journal of Cancer
Intratumor heterogeneity of colorectal cancers (CRCs) is manifested both at the genomic and epigenomic levels. Early genetic aberrations in carcinogenesis are clonal and present throughout the tumors, but less is known about the heterogeneity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed527a247b7b33ee36c55b1653208a2f
http://hdl.handle.net/10852/82751
http://hdl.handle.net/10852/82751
Publikováno v:
Human Genomics
Human Genomics, Vol 12, Iss 1, Pp 1-13 (2018)
Human Genomics, Vol 12, Iss 1, Pp 1-13 (2018)
Background Deleterious variants in the tumour suppressor BRCA1 are known to cause hereditary breast and ovarian cancer syndrome (HBOC). Missense variants in BRCA1 pose a challenge in clinical care, as their effect on protein functionality often remai