Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonas L Fowler"'
Autor:
Julien G Roth, Kristin L Muench, Aditya Asokan, Victoria M Mallett, Hui Gai, Yogendra Verma, Stephen Weber, Carol Charlton, Jonas L Fowler, Kyle M Loh, Ricardo E Dolmetsch, Theo D Palmer
Publikováno v:
eLife, Vol 9 (2020)
Microdeletions and microduplications of the 16p11.2 chromosomal locus are associated with syndromic neurodevelopmental disorders and reciprocal physiological conditions such as macro/microcephaly and high/low body mass index. To facilitate cellular a
Externí odkaz:
https://doaj.org/article/833816900dca490aba4c8edb5bf0a981
Autor:
Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. Here we develop a simpli
Externí odkaz:
https://doaj.org/article/8e8d0192fda64084872f8d3b27e40339
Autor:
Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.
Externí odkaz:
https://doaj.org/article/1bf355be0de745bc987455ce3536745a
Autor:
Lay Teng Ang, Alana T. Nguyen, Kevin J. Liu, Angela Chen, Xiaochen Xiong, Matthew Curtis, Renata M. Martin, Brian C. Raftry, Chun Yi Ng, Uwe Vogel, Angelika Lander, Benjamin J. Lesch, Jonas L. Fowler, Alyssa R. Holman, Timothy Chai, Siva Vijayakumar, Fabian P. Suchy, Toshinobu Nishimura, Joydeep Bhadury, Matthew H. Porteus, Hiromitsu Nakauchi, Christine Cheung, Steven C. George, Kristy Red-Horse, Joseph B. Prescott, Kyle M. Loh
Publikováno v:
Cell
Stem cell research endeavors to generate specific subtypes of classically defined "cell types." Here, we generate90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days. We specified artery cells by inhibiting vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398b2878a7fe54af286099930c34b33e
https://doi.org/10.1016/j.cell.2022.05.024
https://doi.org/10.1016/j.cell.2022.05.024
Autor:
Jonas L Fowler, Angela Chen, Sivakamasundari Vijayakumar, Abidemi Adebayo, Roberta Sala, Lay Teng Ang, Vittorio Sebastiano, Kyle M. Loh, Andrea Cipriano, Gugene Kang
Generating primordial germ cells (PGCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but currently entails complex 3D aggregates. Here we develop a simplified, monolayer m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2fc1299d7ccfe23ee3f748357bf60f
https://doi.org/10.21203/rs.3.rs-113078/v1
https://doi.org/10.21203/rs.3.rs-113078/v1
Autor:
Ricardo E. Dolmetsch, Kristin L Muench, Yogendra Verma, Theo D. Palmer, Hui Gai, Jonas L Fowler, Aditya Asokan, Victoria M Mallett, Kyle M. Loh, Stephen Weber, Julien G Roth, Carol Charlton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927a53be125da7fc15b1f3d508cee9e2
https://doi.org/10.7554/elife.58178.sa2
https://doi.org/10.7554/elife.58178.sa2
Autor:
M. Kyle Cromer, Jonas L Fowler, Nobuko Uchida, Toshinobu Nishimura, Renata M. Martin, Ezequiel Ponce, Matthew H. Porteus, Kyle M. Loh, Benjamin J. Lesch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69c966505b5c9ba3e4b529916b33085
https://doi.org/10.1038/s41467-020-16455-7
https://doi.org/10.1038/s41467-020-16455-7
Publikováno v:
Wiley Interdiscip Rev Dev Biol
Too many choices can be problematic. This is certainly the case for human pluripotent stem cells (hPSCs): they harbor the potential to differentiate into hundreds of cell types; yet it is highly challenging to exclusively differentiate hPSCs into a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b07a85ecaf8a686cfa7a7324ea3a78c
https://europepmc.org/articles/PMC7397816/
https://europepmc.org/articles/PMC7397816/
Autor:
Zachary C Wesner, Steve S. Lee, Scott K. Olehnik, Stephen J. Kron, Manami Hara, Jonas L. Fowler
Publikováno v:
Endocrinology. 159(3)
Pancreatic islets are endocrine micro-organs scattered throughout the exocrine pancreas. Islets are surrounded by a network of vasculature, ducts, neurons, and extracellular matrix. Three-dimensional imaging is critical for such structural analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92900a2ff2299dd858bbbe591c388ab1
https://pubmed.ncbi.nlm.nih.gov/29390052
https://pubmed.ncbi.nlm.nih.gov/29390052
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Pancreatic beta-cell mass is a critical determinant of the progression of diabetes. The loss of beta-cells in various types of diabetes has been documented in comparison to age, sex and body mass index (BMI) matched control subjects. However, the und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6af92a0567ec9126a962468d7b4f28
https://pubmed.ncbi.nlm.nih.gov/29180621
https://pubmed.ncbi.nlm.nih.gov/29180621