Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonas Kath"'
Autor:
Viktor Glaser, Christian Flugel, Jonas Kath, Weijie Du, Vanessa Drosdek, Clemens Franke, Maik Stein, Axel Pruß, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Multiple genetic modifications may be required to develop potent off-the-shelf chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling
Externí odkaz:
https://doaj.org/article/f8d60eb28eca4425aa804f59ead59de2
Autor:
Jonas Kath, Weijie Du, Alina Pruene, Tobias Braun, Bernice Thommandru, Rolf Turk, Morgan L. Sturgeon, Gavin L. Kurgan, Leila Amini, Maik Stein, Tatiana Zittel, Stefania Martini, Lennard Ostendorf, Andreas Wilhelm, Levent Akyüz, Armin Rehm, Uta E. Höpken, Axel Pruß, Annette Künkele, Ashley M. Jacobi, Hans-Dieter Volk, Michael Schmueck-Henneresse, Renata Stripecke, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 311-330 (2022)
Chimeric antigen receptor (CAR) redirected T cells are potent therapeutic options against hematological malignancies. The current dominant manufacturing approach for CAR T cells depends on retroviral transduction. With the advent of gene editing, ins
Externí odkaz:
https://doaj.org/article/007e0c658baf459b90751503a142b022
Autor:
Tobias Braun, Alina Pruene, Milita Darguzyte, Alexander F. vom Stein, Phuong-Hien Nguyen, Dimitrios L. Wagner, Jonas Kath, Alicia Roig-Merino, Michael Heuser, Lucas L. Riehm, Andreas Schneider, Sabine Awerkiew, Steven R. Talbot, André Bleich, Constanca Figueiredo, Martin Bornhäuser, Renata Stripecke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe ubiquitous Epstein–Barr virus (EBV) is an oncogenic herpes virus associated with several human malignancies. EBV is an immune-evasive pathogen that promotes CD8+ T cell exhaustion and dysregulates CD4+ T cell functions. Burkitt lymp
Externí odkaz:
https://doaj.org/article/9836c1f384524f31a1291158cf5bcf4b
Autor:
Julia Sbierski-Kind, Jonas Kath, Sebastian Brachs, Mathias Streitz, Matthias G. von Herrath, Anja A. Kühl, Katharina Schmidt-Bleek, Knut Mai, Joachim Spranger, Hans-Dieter Volk
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Obesity is associated with adipose tissue inflammation, insulin resistance, and the development of type 2 diabetes (T2D). However, our knowledge is mostly based on conventional murine models and promising preclinical studies rarely translated into su
Externí odkaz:
https://doaj.org/article/ec65ee0a6c594a3daae3a9fbe1934be3
Autor:
Anke Jurisch, Joachim Spranger, Anne-Marie Decker, Nina Babel, Leon Kuchenbecker, Mikalai Nienen, Julia Sbierski-Kind, K Mai, Leonard Spranger, Jonas Kath, Ulrike Krüger, Reiner Jumpertz von Schwartzenberg, Karsten Jürchott, Hans-Dieter Volk, Mathias Streitz
Publikováno v:
The Journal of Immunology. 205:45-55
The worldwide epidemic of overweight and obesity has led to an increase in associated metabolic comorbidities. Obesity induces chronic low-grade inflammation in white adipose tissue (WAT). However, the function and regulation of both innate and adapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbc82d7c51e48de4ee66046511f058d
https://doi.org/10.4049/jimmunol.2000108
https://doi.org/10.4049/jimmunol.2000108
Autor:
Ilona Gottschalk, Uwe Kölsch, Dimitrios L. Wagner, Jonas Kath, Stefania Martini, Renate Krüger, Anne Puel, Jean-Laurent Casanova, Aleksandra Jezela-Stanek, Rainer Rossi, Salima El Chehadeh, Hilde Van Esch, Horst von Bernuth
Publikováno v:
Journal of clinical immunology.
Abstract Purpose Besides their developmental and neurological phenotype, most patients with MECP2/IRAK1 duplication syndrome present with recurrent and severe infections, accompanied by strong inflammation. Respiratory infections are the most common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20418c2d2fd6daf8c030b2b842624de3
https://pubmed.ncbi.nlm.nih.gov/36319802
https://pubmed.ncbi.nlm.nih.gov/36319802
Autor:
Axel Pruß, Petra Reinke, Hans-Dieter Volk, Bernice Thommandru, Uta E. Höpken, Dimitrios L. Wagner, Annette Künkele, Rolf Turk, Levent Akyüz, Michael Schmueck-Henneresse, Armin Rehm, Stefania Martini, Leila Amini, Andreas Wilhelm, Weijie Du, Tatiana Zittel, Lennard Ostendorf, Ashley M. Jacobi, Jonas Kath, Maik Stein
Chimeric Antigen Receptor (CAR) redirected T cells are a potent treatment option for certain hematological malignancies. Recently, site-specific insertion of CARs into the T cell receptor (TCR) alpha constant (TRAC) locus using gene editing and adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d539c6638dc00a0eeefc2c0d90868
http://edoc.mdc-berlin.de/20007/7/20007suppl.zip
http://edoc.mdc-berlin.de/20007/7/20007suppl.zip
Autor:
Michael Schmueck-Henneresse, Lennard Ostendorf, Ashley M. Jacobi, T. Zittel, A. Wilhelm, Bernice Thommandru, A. Pruss, Levent Akyuez, Weijie Du, M. Stein, Hans-Dieter Volk, A. Kuenkele, S. Martini, Jonas Kath, U. E. Hoepken, Rolf Turk, Armin Rehm, L. Amini, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
bioRxiv
Chimeric Antigen Receptor (CAR) redirected T cells are a potent treatment option for certain hematological malignancies. Recently, site-specific insertion of CARs into the T cell receptor (TCR) alpha constant (TRAC) locus using gene editing and adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14f6c164c5fc0b4e28b5c2d0a3b31be
Autor:
Anne-Marie Decker, Joachim Spranger, Leon Kuchenbecker, Reiner Jumpertz von Schwartzenberg, K Mai, Ulrike Krüger, Anke Jurisch, Karsten Jürchott, Mathias Streitz, Jonas Kath, Leonard Spranger, Julia Sbierski-Kind, Hans-Dieter Volk
Obesity is a growing global health problem due to its association with chronic low-grade inflammation contributing to metabolic complications. Multiple studies indicate that white adipose tissue (WAT) inflammation can drive the pathogenesis of type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27860fe2ebd670baf625c8c02751537
Autor:
Katharina Schmidt-Bleek, Julia Sbierski-Kind, Jonas Kath, Joachim Spranger, Hans-Dieter Volk, Mathias Streitz
Publikováno v:
Journal of visualized experiments : JoVE. (146)
Obesity is associated with chronic low-grade inflammation and insulin resistance, contributing to an increasing prevalence of chronic metabolic diseases, such as type 2 diabetes and nonalcoholic steatohepatitis (NASH). Recent research has established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da23b71737d3af0c7f9e8518824ffc5
https://pubmed.ncbi.nlm.nih.gov/31081822
https://pubmed.ncbi.nlm.nih.gov/31081822