Comparison of Interim PET Response to Second-Line Versus First-Line Treatment in Classic Hodgkin Lymphoma: Contribution to the Development of Response Criteria for Relapsed or Progressive Disease

Autor: Thomas Georgi, W. Hamish B. Wallace, Lisa Lyngsie Hjalgrim, Jonas Karlén, Francesco Ceppi, Michaela Cepelova, Osama Sabri, Tomasz Klekawka, Tim Wittig, Alexander Fosså, Ana Fernández-Teijeiro, Dirk Hasenclever, Auke Beishuizen, Christine Mauz-Körholz, Jane Pears, Dieter Körholz, Lars Kurch, Regine Kluge

Publikováno v: Journal of Nuclear Medicine. 62:338-341

In first-line treatment of Hodgkin lymphoma (HL), Deauville scores 1-3 define complete metabolic remission. Interim 18F-FDG PET is also used for relapse-treatment adaptation; however, PET response criteria are not validated for relapse treatment. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcac827faf6ffc1ac0f3c7120f115fd
https://doi.org/10.2967/jnumed.120.247924

Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial

Autor: Christine Mauz-Körholz, Judith Landman-Parker, Walentyna Balwierz, Roland A Ammann, Richard A Anderson, Andische Attarbaschi, Jörg M Bartelt, Auke Beishuizen, Sabah Boudjemaa, Michaela Cepelova, Alexander Claviez, Stephen Daw, Karin Dieckmann, Ana Fernández-Teijeiro, Alexander Fosså, Stefan Gattenlöhner, Thomas Georgi, Lisa L Hjalgrim, Andrea Hraskova, Jonas Karlén, Regine Kluge, Lars Kurch, Thiery Leblanc, Georg Mann, Francoise Montravers, Jean Pears, Tanja Pelz, Vladan Rajić, Alan D Ramsay, Dietrich Stoevesandt, Anne Uyttebroeck, Dirk Vordermark, Dieter Körholz, Dirk Hasenclever, William Hamish Wallace

Publikováno v: Mauz-Körholz, Christine; Landman-Parker, Judith; Balwierz, Walentyna; Ammann, Roland A; Anderson, Richard A; Attarbaschi, Andische; Bartelt, Jörg M; Beishuizen, Auke; Boudjemaa, Sabah; Cepelova, Michaela; Claviez, Alexander; Daw, Stephen; Dieckmann, Karin; Fernández-Teijeiro, Ana; Fosså, Alexander; Gattenlöhner, Stefan; Georgi, Thomas; Hjalgrim, Lisa L; Hraskova, Andrea; Karlén, Jonas; ... (2022). Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial. The lancet oncology, 23(1), pp. 125-137. Elsevier 10.1016/S1470-2045(21)00470-8
The Lancet Oncology, 23(1), 125-137. Lancet Publishing Group

Background: Children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma achieve an event-free survival at 5 years of about 90% after treatment with vincristine, etoposide, prednisone, and doxorubicin (OEPA) followed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17f98ceac9d994496e53ddc8caae8a6
https://pubmed.ncbi.nlm.nih.gov/35364689

qPET – a quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma

Autor: Auke Beishuizen, Judith Landman-Parker, Andrea Hraskova, Anne Uyttebroeck, Alexander Fosså, Christine Mauz-Körholz, Dieter Körholz, Ana Fernandez-Teijeiro, Eva Bergsträsser, Hamish Wallace, Andishe Attarbaschi, Jane Pears, Thomas Georgi, Lars Kurch, Jonas Karlén, Andreas Elsner, Eckhard Schomerus, Michaela Cepelova, Osama Sabri, Regine Kluge, Dirk Hasenclever, Angelina Moryl-Bujakowska

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 41(7), 1301-1308. Springer-Verlag

Interim FDG-PET is used for treatment tailoring in lymphoma. Deauville response criteria consist of five ordinal categories based on visual comparison of residual tumor uptake to physiological reference uptakes. However, PET-response is a continuum a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22515ffefc72236e3dbbd3b0577fa20c
https://doi.org/10.1007/s00259-014-2715-9

The role of tumour-infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children

Autor: Annika Englund, Ingrid Glimelius, Jonas Karlén, Daniel Molin, Gunilla Enblad, Gustaf Ljungman, Rose-Marie Amini

OBJECTIVES: To study Hodgkin lymphoma (HL) microenvironment in a Swedish paediatric population and its relation to clinical parameters. METHODS: Tumour tissue from classical HL (cHL) (n=87) and nodular lymphocyte predominant HL (NLPHL) (n=11) was inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b03174f7def73525e6b81aaf04ec2a4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278917

Failure rate of standard rescue with leucovorin for high-dose methotrexate (HDMTX) in osteosarcoma

Autor: Louise Kvistgaard, Magdalena Rychlowska-Pruszynska, Jonas Karlén, Monika Csóka, Mikael Eriksson, Karin M E Ganlov, Kirsten Sundby Hall, Pia Lisjö

Publikováno v: Journal of Clinical Oncology. 35:11028-11028

11028 Background: HDMTX followed by leucovorin rescue is well established as part of MAP chemotherapy for osteosarcoma. However, leucovorin rescue is not always effective as rescue, resulting in delays to subsequent courses of chemotherapy. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ddf951d40d11be3d37c3208d5774bcb
https://doi.org/10.1200/jco.2017.35.15_suppl.11028