Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jonas J. Calsbeek"'
Autor:
Peter M. Andrew, Wei Feng, Jonas J. Calsbeek, Shane P. Antrobus, Gennady A. Cherednychenko, Jeremy A. MacMahon, Pedro N. Bernardino, Xiuzhen Liu, Danielle J. Harvey, Pamela J. Lein, Isaac N. Pessah
Publikováno v:
Toxics, Vol 12, Iss 4, p 263 (2024)
Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can produce seizures that rapidly progress to life-threatening status epilepticus. Significant research effort has been focused on investigating the involvement of muscarinic ace
Externí odkaz:
https://doaj.org/article/7fb803086fdf4bbcb9efc66337280bca
Autor:
Eduardo A. González, Jonas J. Calsbeek, Yi-Hua Tsai, Mei-Yun Tang, Peter Andrew, Joan Vu, Elizabeth L. Berg, Naomi H. Saito, Danielle J. Harvey, Suangsuda Supasai, Gene G. Gurkoff, Jill L. Silverman, Pamela J. Lein
Publikováno v:
Current Research in Toxicology, Vol 2, Iss , Pp 341-356 (2021)
Preclinical efforts to improve medical countermeasures against organophosphate (OP) chemical threat agents have largely focused on adult male models. However, age and sex have been shown to influence the neurotoxicity of repeated low-level OP exposur
Externí odkaz:
https://doaj.org/article/22f608d09350421494ce98bb95f80fc0
Autor:
Jonas J. Calsbeek, Naomi H. Saito, Jill L. Silverman, Danielle J Harvey, Michelle Guignet, Jeremy A. MacMahon, Nycole A. Copping, Donald A. Bruun, Mallory E. Dawson, Pamela J. Lein, Eduardo A. González, Alexandria J. Yu
Publikováno v:
Neurotoxicology
Organophosphate (OP) nerve agents and pesticides are a class of neurotoxic compounds that can cause status epilepticus (SE), and death following acute high-dose exposures. While the standard of care for acute OP intoxication (atropine, oxime, and hig
Autor:
Danielle J Harvey, Peter Andrew, Jonas J. Calsbeek, Eduardo A. González, Suangsuda Supasai, Naomi H. Saito, Mei Yun Tang, Yi Hua Tsai, Elizabeth L. Berg, Joan Vu, Jill L. Silverman, Pamela J. Lein, Gene G. Gurkoff
Publikováno v:
Current Research in Toxicology, Vol 2, Iss, Pp 341-356 (2021)
Current Research in Toxicology
Current Research in Toxicology
Graphical abstract
Highlights • DFP-induced seizures and neuroinflammation were more severe in males than females. • Acute DFP intoxication caused persistent sex-specific brain damage in juvenile rats. • Both sexes experienced cognitive de
Highlights • DFP-induced seizures and neuroinflammation were more severe in males than females. • Acute DFP intoxication caused persistent sex-specific brain damage in juvenile rats. • Both sexes experienced cognitive de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d76f0482cb9720f33ab266bcd8c8c1
https://escholarship.org/uc/item/2md86990
https://escholarship.org/uc/item/2md86990
Autor:
Eduardo A. González, Danielle J Harvey, Ashish Dhir, Donald A. Bruun, Daniel J. Tancredi, Pamela J. Lein, Jonas J. Calsbeek, Naomi Saito, Michelle Guignet, Joan Vu, Yi Hua Tsai, Michael A. Rogawski
Publikováno v:
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences, vol 1480, iss 1
Annals of the New York Academy of Sciences, vol 1480, iss 1
Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous hig
Autor:
Naomi Saito, Michelle Guignet, Ashish Dhir, Alexa C. Rindy, Douglas J. Rowland, Pamela J. Lein, Eduardo A. González, Peter Andrew, Danielle J Harvey, Jonas J. Calsbeek, Donald A. Bruun, Michael A. Rogawski
Publikováno v:
Archives of toxicology, vol 94, iss 6
Arch Toxicol
Arch Toxicol
Organophosphate (OP) threat agents can trigger seizures that progress to status epilepticus, resulting in persistent neuropathology and cognitive deficits in humans and preclinical models. However, it remains unclear whether patients who do not show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fca4ec1730dafab228789677ef77af
https://escholarship.org/uc/item/9ch567m9
https://escholarship.org/uc/item/9ch567m9
Publikováno v:
Behavioural Brain Research. 317:502-507
Opioids are effective at inhibiting responses to noxious stimuli in rodents, but have limited efficacy and many side effects in chronic pain patients. One reason for this disconnect is that nociception is typically assessed using withdrawal from noxi
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Journal of Neuroscience Methods. 263:115-122
Background The assessment of nociception in preclinical studies is undergoing a transformation from pain-evoked to pain-depressed tests to more closely mimic the effects of clinical pain. Many inflammatory pain-depressed behaviors (reward seeking, lo
Autor:
Michael A. Rogawski, Casey A. Boosalis, Pamela J. Lein, Eduardo A. González, Jonas J. Calsbeek, Dorota Zolkowska
Publikováno v:
The FASEB Journal. 32