Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jonas Ibn-Salem"'
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wi
Externí odkaz:
https://doaj.org/article/5555b6f69f604e28aaf67331a614a97d
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide
Externí odkaz:
https://doaj.org/article/b7c2181126584be78605a8f18500a472
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation
Externí odkaz:
https://doaj.org/article/ee46fcca7eb245e694cdcfa97f7a36eb
Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens
Autor:
David Weber, Jonas Ibn-Salem, Patrick Sorn, Martin Suchan, Christoph Holtsträter, Urs Lahrmann, Isabel Vogler, Kathrin Schmoldt, Franziska Lang, Barbara Schrörs, Martin Löwer, Ugur Sahin
Publikováno v:
Nature Biotechnology
Nat Biotechnol
Nat Biotechnol
Cancer associated gene fusions (GF) are a potential source for highly immunogenic neo-antigens, but the lack of computational tools for accurate, sensitive identification of personal GFs has limited their targeting in personalized cancer immunotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f451bc3a74374e4f8f9989754534e6f6
https://doi.org/10.1038/s41587-022-01247-9
https://doi.org/10.1038/s41587-022-01247-9
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-10 (2019)
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-10 (2019)
Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f81d4193be13a66ce8bb91e0f015816
https://pubmed.ncbi.nlm.nih.gov/31805995
https://pubmed.ncbi.nlm.nih.gov/31805995
Autor:
Daniel T. Zuch, John D. Hogan, Jonas Ibn-Salem, Miguel A. Andrade-Navarro, Bernd Timmermann, Lingqi Luo, Cynthia A. Bradham, Daphne Schatzberg, Jessica L. Keenan, Naoki Irie, Albert J. Poustka, José Horacio Grau, Dakota Y. Hawkins, Amanda B. Core, Carolyn Blumberg, Emily Speranza, Arjun Lamba, Michael L. Piacentino
Publikováno v:
bioRxiv
Developmental Biology
Developmental Biology
Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly valuable model organism fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee7b9ba73ded6efba4e3292e8c47f49
Autor:
Johannes T. Roehr, Peter N. Robinson, Peter Hansen, Michael A. Gargano, Guy Karlebach, Jonas Ibn-Salem, Jochen Hecht
Publikováno v:
Genes, Vol 10, Iss 7, p 548 (2019)
Genes
Genes
Hi-C, capture Hi-C (CHC) and Capture-C have contributed greatly to our present understanding of the three-dimensional organization of genomes in the context of transcriptional regulation by characterizing the roles of topological associated domains,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbcb6ddc1386873ab2b2877a597e4ad
http://hdl.handle.net/10230/42350
http://hdl.handle.net/10230/42350
Publikováno v:
BMC Biology
BMC Biology, Vol 16, Iss 1, Pp 1-12 (2018)
BMC Biology, Vol 16, Iss 1, Pp 1-12 (2018)
BackgroundThe human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation by restri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9041a7377498b720ce7b2a507ca126c7
http://europepmc.org/articles/PMC6091198
http://europepmc.org/articles/PMC6091198
Autor:
Marcel Jurk, Sebastiaan H. Meijsing, Martin Vingron, Morgane Thomas-Chollier, Michael I. Love, Jonas Ibn-Salem, Ho-Ryun Chung, Stephan R. Starick, Céline Hernandez
Publikováno v:
Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Research, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Res
Genome Research, Cold Spring Harbor Laboratory Press, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Research, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Res
The classical DNA recognition sequence of the glucocorticoid receptor (GR) appears to be present at only a fraction of bound genomic regions. To identify sequences responsible for recruitment of this transcription factor (TF) to individual loci, we t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694f8c781f0deae07332f08eba894e24
https://doi.org/10.1101/gr.185157.114
https://doi.org/10.1101/gr.185157.114
Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements
Autor:
Lynne M. Bird, Fowzan S. Alkuraya, Jennifer MacKenzie, Rebecca Sparkes, Andrea L. Gropman, Cinthya J. Zepeda-Mendoza, Brett H. Graham, Campbell K. Brasington, Diane Masser-Frye, Zehra Ordulu, Debra Rita, Karen W. Gripp, Edward J. Spence, Jonas Ibn-Salem, Erica Spiegel, Ranad Shaheen, Michael E. Talkowski, Tammy Kammin, Cynthia C. Morton, Miguel A. Andrade-Navarro, Peter N. Robinson, David J. Harris
Publikováno v:
American journal of human genetics, vol 101, iss 2
Zepeda-Mendoza, C J, Ibn-Salem, J, Kammin, T, Harris, D J, Rita, D, Gripp, K W, MacKenzie, J J, Gropman, A L, Graham, B H, Shaheen, R, Alkuraya, F S, Brasington, C K, Spence, E J, Masser-Frye, D, Bird, L M, Spiegel, E, Sparkes, R L, Ordulu, Z, Talkowski, M E, Andrade-Navarro, M A, Robinson, P N & Morton, C C 2017, ' Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2017.06.011
Zepeda-Mendoza, C J, Ibn-Salem, J, Kammin, T, Harris, D J, Rita, D, Gripp, K W, MacKenzie, J J, Gropman, A L, Graham, B H, Shaheen, R, Alkuraya, F S, Brasington, C K, Spence, E J, Masser-Frye, D, Bird, L M, Spiegel, E, Sparkes, R L, Ordulu, Z, Talkowski, M E, Andrade-Navarro, M A, Robinson, P N & Morton, C C 2017, ' Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2017.06.011
Interpretation of variants of uncertain significance, especially chromosomal rearrangements in non-coding regions of the human genome, remains one of the biggest challenges in modern molecular diagnosis. To improve our understanding and interpretatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b6b7bb10a88c1688004b3cc06fa972
https://pubmed.ncbi.nlm.nih.gov/28735859
https://pubmed.ncbi.nlm.nih.gov/28735859