Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jonas Helma"'
Autor:
Jonas Helma, Katrin Schmidthals, Vanda Lux, Stefan Nüske, Armin M Scholz, Hans-Georg Kräusslich, Ulrich Rothbauer, Heinrich Leonhardt
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50026 (2012)
In basic and applied HIV research, reliable detection of viral components is crucial to monitor progression of infection. While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to d
Externí odkaz:
https://doaj.org/article/58176e846e5844b7aa0f1855c1f5723d
Autor:
Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma, Marc-André Kasper, Christian P. R. Hackenberger
Publikováno v:
Chemical Science. 14:2259-2266
Compact phosphonamidate building blocks enable the simple construction of homogeneous DAR8 ADCs from native antibodies and hydrophobic payloads. The resulting ADCs exhibit excellent in vivo stability, clearance rates and antitumor activity.
Autor:
Maike Roas, Binje Vick, Marc-André Kasper, Marina Able, Harald Polzer, Marcus Gerlach, Elisabeth Kremmer, Judith S. Hecker, Saskia Schmitt, Andreas Stengl, Verena Waller, Natascha Hohmann, Moreno Festini, Alexander Ludwig, Lisa Rohrbacher, Tobias Herold, Marion Subklewe, Katharina S. Götze, Christian P. R. Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
Publikováno v:
Blood 141, 1023-1035 (2023)
Fms-like tyrosine kinase 3 (FLT3) is often overexpressed or constitutively activated by internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations in acute myeloid leukemia (AML). Despite the use of receptor tyrosine kinase inhibito
Autor:
Marcus Gerlach, Saskia Schmitt, Philipp Cyprys, Marc-André Kasper, Isabelle Mai, Maarten H. Vermeer, Steven M. Horwitz, Guenter R Fingerle-Rowson, Annette Vogl, Dominik Schumacher, Jonas Helma-Smets
Publikováno v:
Blood. 140:9397-9398
Autor:
Ksenia Kolobynina, Christian P. R. Hackenberger, Heinrich Leonhardt, Jonathan Schwach, Katharina Brandstetter, Hartmann Harz, Philipp Ochtrop, M. Cristina Cardoso, Marcus Gerlach, Andreas Stengl, Jonas Helma
Publikováno v:
Chembiochem
Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. Antibody‐oligonucleotide con
Autor:
Marc‐André Kasper, Lukas Lassak, Annette M. Vogl, Isabelle Mai, Jonas Helma, Dominik Schumacher, Christian P. R. Hackenberger
Bis-ethynylphosphonamidates allow for a simple chemoselective addition of two thiol-containing modules in a row. We describe four such bis-electrophiles that carry different functional O-substituents with tunable hydrophilicity and enable further sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8910f1842006a28c72ee1d9597f101b
http://edoc.hu-berlin.de/18452/25489
http://edoc.hu-berlin.de/18452/25489
Autor:
Marcus Gerlach, Anselm F. L. Schneider, Dominik Schumacher, Marc-André Kasper, Jonas Helma, Christian P. R. Hackenberger, Stefanie Boldt, Heinrich Leonhardt, Mathias Christmann, Philipp Ochtrop, Christiane Groneberg
Publikováno v:
Chembiochem
Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and p
Autor:
Marc‐André Kasper, Andreas Stengl, Philipp Ochtrop, Marcus Gerlach, Tina Stoschek, Dominik Schumacher, Jonas Helma, Martin Penkert, Eberhard Krause, Heinrich Leonhardt, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie. 131:11757-11762
Autor:
Heinrich Leonhardt, Christian P. R. Hackenberger, Jonas Helma, Anselm F. L. Schneider, Dominik Schumacher
Publikováno v:
Angewandte Chemie (International Ed. in English)
Nanobodies can be seen as next‐generation tools for the recognition and modulation of antigens that are inaccessible to conventional antibodies. Due to their compact structure and high stability, nanobodies see frequent usage in basic research, and
Autor:
Anselm F. L. Schneider, Heinrich Leonhardt, Christian P. R. Hackenberger, Jonas Helma, Dominik Schumacher
Publikováno v:
Angewandte Chemie. 130:2336-2357
Nanobodies can be considered as next-generation life science tools for the recognition and modulation of antigens that are inaccessible to conventional antibodies. Due to their compact structure and high stability, nanobodies see frequent usage in ba