Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jonas Hanske"'
Autor:
Rob van Dalen, Jacinto S. De La Cruz Diaz, Matevž Rumpret, Felix F. Fuchsberger, Nienke H. van Teijlingen, Jonas Hanske, Christoph Rademacher, Teunis B. H. Geijtenbeek, Jos A. G. van Strijp, Christopher Weidenmaier, Andreas Peschel, Daniel H. Kaplan, Nina M. van Sorge
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD [eczema]). Epicutaneous exposure to S. aureus induces Th17 responses through skin Langerhans cell
Externí odkaz:
https://doaj.org/article/5381197dcad241c8928ae7c4eb2becaf
Publikováno v:
eLife, Vol 8 (2019)
RNA polymerase (Pol) I is a 14-subunit enzyme that solely transcribes pre-ribosomal RNA. Cryo-electron microscopy (EM) structures of Pol I initiation and elongation complexes have given first insights into the molecular mechanisms of Pol I transcript
Externí odkaz:
https://doaj.org/article/244403cef01148f9b74c97d0c9727d3c
Autor:
Felix Broecker, Jonas Hanske, Christopher E. Martin, Ju Yuel Baek, Annette Wahlbrink, Felix Wojcik, Laura Hartmann, Christoph Rademacher, Chakkumkal Anish, Peter H. Seeberger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen,
Externí odkaz:
https://doaj.org/article/14c948723fd84a6ab537dce51dcba054
Publikováno v:
Current Opinion in Structural Biology
Graphical abstract
Highlights • Gold rush in cryo-EM structure determination of challenging transcription complexes. • Initiation complexes of all eukaryotic RNA polymerases have been solved by cryo-EM. • Cryo-EM structures of chromatin mo
Highlights • Gold rush in cryo-EM structure determination of challenging transcription complexes. • Initiation complexes of all eukaryotic RNA polymerases have been solved by cryo-EM. • Cryo-EM structures of chromatin mo
Autor:
Dieter E. Kaufmann, Jonas Aretz, Peter H. Seeberger, Elena Shanina, Jonas Hanske, Hannes Baukmann, Robert Wawrzinek, Viktor A. Zapol'skii, Christoph Rademacher
Publikováno v:
Angewandte Chemie. 129:7398-7402
Der Oberflachenrezeptor DC-SIGN ermoglicht die Aufnahme von Krankheitserregern wie HIV, Ebolavirus oder Mycobacterium tuberculosis. Daher gab es zahlreiche Versuche, Inhibitoren gegen die Bindung dieses Rezeptors an Kohlenhydratstrukturen dieser Path
Autor:
Christoph Rademacher, Daniel H. Kaplan, Felix F. Fuchsberger, Nina M. van Sorge, Teunis B. H. Geijtenbeek, Andreas Peschel, Nienke H. van Teijlingen, Christopher Weidenmaier, Jacinto S. De La Cruz Diaz, Rob van Dalen, Jos A. G. van Strijp, Matevž Rumpret, Jonas Hanske
Publikováno v:
mBio
mBio, Vol 10, Iss 3 (2019)
mBio, 10(3). American Society for Microbiology
mBio, Vol 10, Iss 3, p e00330-19 (2019)
mBio, 10(3):e00330-19. American Society for Microbiology
mBio, Vol 10, Iss 3 (2019)
mBio, 10(3). American Society for Microbiology
mBio, Vol 10, Iss 3, p e00330-19 (2019)
mBio, 10(3):e00330-19. American Society for Microbiology
The bacterium Staphylococcus aureus is an important cause of skin infections and is also associated with the occurrence and severity of eczema. Langerhans cells (LCs), a specific subset of skin immune cells, participate in the immune response to S. a
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
RNA polymerase (Pol) I is a 14-subunit enzyme that solely transcribes pre-ribosomal RNA. Cryo-electron microscopy (EM) structures of Pol I initiation and elongation complexes have given first insights into the molecular mechanisms of Pol I transcript
Autor:
Jonas Hanske, Elena Shanina, Peter Schmieder, Martin Ballaschk, Monika Beerbaum, Stevan Aleksić, Bettina G. Keller, Christoph Rademacher, Marcel Jurk
Publikováno v:
Journal of the American Chemical Society
Antigen uptake and processing by innate immune cells is crucial to initiate the immune response. Therein, the endocytic C-type lectin receptors serve as pattern recognition receptors, detecting pathogens by their glycan structures. Herein, we studied
Autor:
Eike-Christian Wamhoff, Jonas Aretz, Jonas Hanske, Daniel Varón Silva, Maurice Grube, Lennart Schnirch, Christoph Rademacher
Publikováno v:
ACS Chemical Biology
C-type lectin receptors (CLRs) play a pivotal role in pathogen defense and immune homeostasis. Langerin, a CLR predominantly expressed on Langerhans cells, represents a potential target receptor for the development of anti-infectives or immunomodulat