Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jonas Goldin, Diness"'
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100898- (2021)
Background: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion c
Externí odkaz:
https://doaj.org/article/82411e8ecce4417c847b406d7fefec9e
Autor:
Merle Friederike Fenner, Giulia Gatta, Stefan Sattler, Marion Kuiper, Eva Melis Hesselkilde, Ditte M. T. Adler, Morten Smerup, Ulrich Schotten, Ulrik Sørensen, Jonas Goldin Diness, Thomas Jespersen, Sander Verheule, Arne Van Hunnik, Rikke Buhl
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundSmall-conductance Ca2+-activated K+ (KCa2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the im
Externí odkaz:
https://doaj.org/article/f83aac8393b7445e81accc751b356660
Autor:
Carlotta Citerni, Jeppe Kirchhoff, Lisbeth Høier Olsen, Stefan Michael Sattler, Morten Grunnet, Nils Edvardsson, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundInhibition of KCa2 channels, conducting IKCa, can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. IKCa inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles.
Externí odkaz:
https://doaj.org/article/a086a10d016b44ba86aca26b558f382f
Autor:
Jonas Goldin Diness, Lea Abildgaard, Sofia Hammami Bomholtz, Mark Alexander Skarsfeldt, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundHypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductan
Externí odkaz:
https://doaj.org/article/20be621c8ddb4634a78c173606c22392
Autor:
Bo Hjorth Bentzen, Sofia Hammami Bomholtz, Rafel Simó-Vicens, Lasse Folkersen, Lea Abildgaard, Tobias Speerschneider, Kalai Mangai Muthukumarasamy, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsSmall conductance Ca2+-activated K+ channels (SK channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2 channels that is currently in clinical development for treatment of AF. The
Externí odkaz:
https://doaj.org/article/f462fdae02ad4e698282f8bd9227d4e9
Autor:
Carlotta Citerni, Jeppe Kirchhoff, Lisbeth Høier Olsen, Stefan Michael Sattler, Fabio Gentilini, Monica Forni, Augusta Zannoni, Morten Grunnet, Nils Edvardsson, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Background: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and/or fast atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with subsequen
Externí odkaz:
https://doaj.org/article/3787b338adb04e7cb4b042685fd546a7
Autor:
Jonas Goldin Diness, Jeppe Egedal Kirchhoff, Tobias Speerschneider, Lea Abildgaard, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsTo describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant
Externí odkaz:
https://doaj.org/article/5c0147df7d244338b19b09ac7b4cb339
Autor:
Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IK
Externí odkaz:
https://doaj.org/article/0dc2f2226e674b7996e9529f482bfbcc
Autor:
Kirsten R. Bergmann, Michiel J. B. Kemme, Ulrik Svane Sørensen, Morten Grunnet, Erica S. Klaassen, Jacobus Burggraaf, Nils Edvardsson, Mahdi Saghari, Bo Hjorth Bentzen, Christina Sylvest, Jonas Goldin Diness, Pim Gal
Publikováno v:
Clinical and Translational Science
Gal, P, Klaassen, E S, Bergmann, K R, Saghari, M, Burggraaf, J, Kemme, M J B, Sylvest, C, Sørensen, U, Bentzen, B H, Grunnet, M, Diness, J G & Edvardsson, N 2020, ' First Clinical Study with AP30663-a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation ', Clinical and Translational Science, vol. 13, no. 6, pp. 1336-1344 . https://doi.org/10.1111/cts.12835
Clinical and Translational Science, 13(6), 1336-1344. Wiley-Blackwell
Gal, P, Klaassen, E S, Bergmann, K R, Saghari, M, Burggraaf, J, Kemme, M J B, Sylvest, C, Sørensen, U, Bentzen, B H, Grunnet, M, Diness, J G & Edvardsson, N 2020, ' First Clinical Study with AP30663-a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation ', Clinical and Translational Science, vol. 13, no. 6, pp. 1336-1344 . https://doi.org/10.1111/cts.12835
Clinical and Translational Science, 13(6), 1336-1344. Wiley-Blackwell
Pharmacological cardioversion of atrial fibrillation (AF) is frequently inefficacious. AP30663, a small conductance Ca2+ activated K+ (KCa2) channel blocker, prolonged the atrial effective refractory period in preclinical studies and subsequently con
Autor:
Marion Kuiper, Jonas Goldin Diness, Vladimír Sobota, Carlotta Citerni, Ulrich Schotten, Bo Hjorth Bentzen, Sander Verheule, Stef Zeemering, Thomas Jespersen, Ulrik Svane Sørensen, Arne van Hunnik, Giulia Gatta
Publikováno v:
EP Europace, 23(11), 1847-1859. Oxford University Press
Gatta, G, Sobota, V, Citerni, C, Diness, J G, Sørensen, U S, Jespersen, T, Bentzen, B H, Zeemering, S, Kuiper, M, Verheule, S, Schotten, U & Van Hunnik, A 2021, ' Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction ', Europace, vol. 23, no. 11, pp. 1847-1859 . https://doi.org/10.1093/europace/euab125
Europace
Gatta, G, Sobota, V, Citerni, C, Diness, J G, Sørensen, U S, Jespersen, T, Bentzen, B H, Zeemering, S, Kuiper, M, Verheule, S, Schotten, U & Van Hunnik, A 2021, ' Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction ', Europace, vol. 23, no. 11, pp. 1847-1859 . https://doi.org/10.1093/europace/euab125
Europace
Aims Pharmacological termination of atrial fibrillation (AF) remains a challenge due to limited efficacy and potential ventricular proarrhythmic effects of antiarrhythmic drugs. SK channels are proposed as atrial-specific targets in the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099681400d1f1504369a513e1071c494
https://cris.maastrichtuniversity.nl/en/publications/a6b6280c-e31e-454f-9491-3bb14c1352d1
https://cris.maastrichtuniversity.nl/en/publications/a6b6280c-e31e-454f-9491-3bb14c1352d1