Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation

Autor: Twinu Wilson Chirayath, Matthias Ollivier, Mete Kayatekin, Isabelle Rubera, Chinh Nghia Pham, Jonas Friard, Nathalie Linck, Hélene Hirbec, Christèle Combes, Mylène Zarka, Frédéric Lioté, Pascal Richette, Francois Rassendren, Vincent Compan, Christophe Duranton, Hang Korng Ea

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Deposition of monosodium urate and calcium pyrophosphate (MSU and CPP) micro-crystals is responsible for painful and recurrent inflammation flares in gout and chondrocalcinosis. In these pathologies, the inflammatory reactions are due to the

Externí odkaz: https://doaj.org/article/c545be87b1204bfc9c995799d6982d19

Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance

Autor: Jonas Friard, Michel Tauc, Marc Cougnon, Vincent Compan, Christophe Duranton, Isabelle Rubera

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Chloride channels play an essential role in a variety of physiological functions and in human diseases. Historically, the field of chloride channels has long been neglected owing to the lack of powerful selective pharmacological agents that are neede

Externí odkaz: https://doaj.org/article/aadde1aa6aed4f788b064e7e7c860fe0

Supplemental materials and methods from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

Autor: Cedric Gaggioli, Dmitry V. Bulavin, Christophe Duranton, Guerrino Meneguzzi, Paul Hofman, Marius Ilie, Alexander Emelyanov, Caroline Bailleux, Majdi Maiel, Margaux Lecacheur, Sabrina Pisano, Isabelle Bourget, Jonas Friard, Alexandre Bozec, Thomas Bertero, Eloise M. Grasset

Supplemental files

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496440c4409e564e5a8acaee016cc8e6
https://doi.org/10.1158/0008-5472.22420407

Data from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

Autor: Cedric Gaggioli, Dmitry V. Bulavin, Christophe Duranton, Guerrino Meneguzzi, Paul Hofman, Marius Ilie, Alexander Emelyanov, Caroline Bailleux, Majdi Maiel, Margaux Lecacheur, Sabrina Pisano, Isabelle Bourget, Jonas Friard, Alexandre Bozec, Thomas Bertero, Eloise M. Grasset

In squamous cell carcinoma (SCC), tissue invasion by collectively invading cells requires physical forces applied by tumor cells on their surrounding extracellular matrix (ECM). Cancer-related ECM is composed of thick collagen bundles organized by ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b1f2e9e1d4ed06a149eeef1db3007d
https://doi.org/10.1158/0008-5472.c.6510639.v1

Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

Autor: Miled Bourourou, Michel Tauc, Jonas Friard, Nicolas Melis, Elsa Gouix, Catherine Heurteaux, Nicolas Blondeau

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2020, pp.0271678X2092888. ⟨10.1177/0271678X20928882⟩
Journal of Cerebral Blood Flow & Metabolism

International audience; In eukaryotes, the polyamine pathway generates spermidine that activates the hypusination of the translation factor eukaryotic initiation factor 5A (eIF5A). Hypusinated-eIF5A modulates translation, elongation, termination and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b37b32bb0cd1ed8b610fda254de73ab
https://hal.archives-ouvertes.fr/hal-02899981/file/2020-Bourourou-JCBFM.pdf