Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Jonas Emsley"'
Autor:
Philip Bardelang, Ewan J. Murray, Isobel Blower, Sara Zandomeneghi, Alice Goode, Rohanah Hussain, Divya Kumari, Giuliano Siligardi, Katsuaki Inoue, Jeni Luckett, James Doutch, Jonas Emsley, Weng C. Chan, Philip Hill, Paul Williams, Boyan B. Bonev
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)
Externí odkaz:
https://doaj.org/article/480be95100e5453b9cb4d3597c09a696
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the pro
Externí odkaz:
https://doaj.org/article/fee674e63493417ba6189ce903242def
Autor:
Nicholas A. Arce, Wenpeng Cao, Alexander K. Brown, Emily R. Legan, Moriah S. Wilson, Emma-Ruoqi Xu, Michael C. Berndt, Jonas Emsley, X. Frank Zhang, Renhao Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement
Externí odkaz:
https://doaj.org/article/717c9b35a0aa4d4d8a77c1b7e9fbb9c1
Autor:
Raquel López-Gálvez, María Eugenia de la Morena-Barrio, Alberto López-Lera, Monika Pathak, Antonia Miñano, Mercedes Serrano, Delphine Borgel, Vanessa Roldán, Vicente Vicente, Jonas Emsley, Javier Corral
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Background Congenital disorders of glycosylation (CDG) are rare diseases with impaired glycosylation and multiorgan disfunction, including hemostatic and inflammatory disorders. Factor XII (FXII), the first element of the contact phase, has
Externí odkaz:
https://doaj.org/article/4bb121c4421d4dd596db13a4bed5ae77
Autor:
Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The plasma metalloprotease ADAMTS13 regulates the platelet-tethering function of von Willebrand factor (VWF) in a shear-dependent manner. Here the authors present the ADAMTS13 crystal structure of the 70kDa N-terminal metalloprotease to spacer domain
Externí odkaz:
https://doaj.org/article/d27f55aa143e48378d1a3aee26caffd6
Autor:
Bruno R Salu, Silvana Cristina Pando, Marlon V De Brito, André Fernando Medina, Frank Odei-Addo, Carminita Frost, Ryno Naude, Misako U Sampaio, Jonas Emsley, Francisco Humberto A. Maffei, Maria Luiza V Oliva
Publikováno v:
Platelets, Vol 30, Iss 3, Pp 305-313 (2019)
The purpose of antithrombotic therapy is the prevention of thrombus formation and/or its extension with a minimum risk of bleeding. The inhibition of a variety of proteolytic processes, particularly those of the coagulation cascade, has been reported
Externí odkaz:
https://doaj.org/article/703b2a2100744a4f9df64ad47a8936c0
Autor:
Fernando Corvillo, María Eugenia de la Morena-Barrio, Carmen Marcos-Bravo, Margarita López-Trascasa, Vicente Vicente, Jonas Emsley, Teresa Caballero, Javier Corral, Alberto López-Lera
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
BackgroundHereditary angioedema due to the Thr328Lys variant in the coagulation factor XII (HAE-FXII) affects mainly women in whom the symptomatology is dependent on high estrogen levels. Clinical variability and incomplete penetrance are challenging
Externí odkaz:
https://doaj.org/article/8c501be6821e43969c9be71be3b16b1b
Autor:
Fadi Soukarieh, Ruiling Liu, Manuel Romero, Shaun N. Roberston, William Richardson, Simone Lucanto, Eduard Vico Oton, Naim Ruhul Qudus, Alaa Mashabi, Scott Grossman, Sadiqur Ali, Tomás Sou, Irena Kukavica-Ibrulj, Roger C. Levesque, Christel A. S. Bergström, Nigel Halliday, Shailesh N. Mistry, Jonas Emsley, Stephan Heeb, Paul Williams, Miguel Cámara, Michael J. Stocks
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Current treatments for Pseudomonas aeruginosa infections are becoming less effective because of the increasing rates of multi-antibiotic resistance. Pharmacological targeting of virulence through inhibition of quorum sensing (QS) dependent virulence
Externí odkaz:
https://doaj.org/article/2028c900e1c64f45a368b4dc67692ee3
Autor:
Maha Othman, Jonas Emsley
Publikováno v:
Platelets, Vol 28, Iss 8, Pp 832-836 (2017)
Externí odkaz:
https://doaj.org/article/134b2af04d6549a6ac542b685f8774d3
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
The contact activation system (CAS) or contact pathway is central to the crosstalk between coagulation and inflammation and contributes to diverse disorders affecting the cardiovascular system. CAS initiation contributes to thrombosis but is not requ
Externí odkaz:
https://doaj.org/article/ed20c7fe7bd14b2db144fe37597d9c8d