MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

Autor: Romain Sigaud, Thomas K. Albert, Caroline Hess, Thomas Hielscher, Nadine Winkler, Daniela Kocher, Carolin Walter, Daniel Münter, Florian Selt, Diren Usta, Jonas Ecker, Angela Brentrup, Martin Hasselblatt, Christian Thomas, Julian Varghese, David Capper, Ulrich W. Thomale, Pablo Hernáiz Driever, Michèle Simon, Svea Horn, Nina Annika Herz, Arend Koch, Felix Sahm, Stefan Hamelmann, Augusto Faria-Andrade, Nada Jabado, Martin U. Schuhmann, Antoinette Y. N. Schouten-van Meeteren, Eelco Hoving, Tilman Brummer, Cornelis M. van Tilburg, Stefan M. Pfister, Olaf Witt, David T. W. Jones, Kornelius Kerl, Till Milde

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors (MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify patients likely to benefit from MAPKi therapy. Here, we identi

Externí odkaz: https://doaj.org/article/87e41da8f9f6492d937e992bb05c9817

Sarcoma classification by DNA methylation profiling

Autor: Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, Andreas von Deimling

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve c

Externí odkaz: https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b

Supplemental Table Legend from A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells

Autor: Till Milde, Olaf Witt, Tilman Brummer, Marc Remke, David T.W. Jones, Stefan M. Pfister, Cornelis M. van Tilburg, Darren Hargrave, Tobias Rubner, Alexander C. Sommerkamp, Johanna Vollmer, Thomas Hielscher, Jonas Ecker, Stefan Pusch, Jennifer Jansen, David Pauck, Viktoria Marquardt, Florian Selt, Juliane L. Buhl, Romain Sigaud, Diren Usta

Includes the legends for Suppl. Table S1-S5.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0453ebece66baf8ab3886add7a01a8
https://doi.org/10.1158/1535-7163.22521343.v1

Supplementary Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Autor: Kristian W. Pajtler, Daisuke Kawauchi, Felix Sahm, Stefan M. Pfister, Andreas von Deimling, Marcel Kool, David T.W. Jones, Richard J. Gilbertson, Stephen C. Mack, Mikio Hoshino, Richard G. Grundy, Till Milde, Matija Snuderl, Johan M. Kros, Pablo Hernáiz Driever, Sebastian Brandner, Ulrich Schüller, Christel C. Herold-Mende, David W. Ellison, David Capper, Vijay Ramaswamy, Andrew M. Donson, Stefan Rutkowski, Gudrun Fleischhack, Guido Reifenberger, Dominique Figarella-Branger, Christine Haberler, Rebecca Chapman, Florian Selt, Philipp Sievers, Jonas Ecker, Dominik Sturm, Nicolas U. Gerber, Ryo Shiraishi, Toma Adachi, Shinichiro Taya, Julia Benzel, Robert Kupp, Amir Arabzade, Damian Stichel, Johannes Gojo, Marina Ryzhova, Patricia Benites Goncalves da Silva, Kendra K. Maass, Martin Sill, Andrey Korshunov, Konstantin Okonechnikov, David R. Ghasemi, Tuyu Zheng

Supplementary Figures and methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a7d8e6db43cdbe898bb8249028318d
https://doi.org/10.1158/2159-8290.22538918.v1

Supplementary Figures S1-S5 from A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells

Autor: Till Milde, Olaf Witt, Tilman Brummer, Marc Remke, David T.W. Jones, Stefan M. Pfister, Cornelis M. van Tilburg, Darren Hargrave, Tobias Rubner, Alexander C. Sommerkamp, Johanna Vollmer, Thomas Hielscher, Jonas Ecker, Stefan Pusch, Jennifer Jansen, David Pauck, Viktoria Marquardt, Florian Selt, Juliane L. Buhl, Romain Sigaud, Diren Usta

Suppl. Figure S1 shows "Initial MAPKi screen using metabolic activity as readout". Suppl. Figure S2 shows "Western blot validation of MAPK pathway alterations in HEK293T cells". Suppl. Figure S3 shows "Dose-response curves of MAPKi combination treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010f5ff900ab07314c3c4d69dde7540d
https://doi.org/10.1158/1535-7163.22521340.v1