Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jonas E. Jensen"'
Publikováno v:
Marine Drugs, Vol 10, Iss 7, Pp 1511-1527 (2012)
APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima. It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of chro
Externí odkaz:
https://doaj.org/article/42627fb81e9b4280b180887c15b87a5b
Autor:
Glenn F. King, Volker Herzig, Lachlan D. Rash, Jonas E. Jensen, Sing Yan Er, Sebastian Senff, Natalie J. Saez
Publikováno v:
Toxins, Vol 2, Iss 12, Pp 2851-2871 (2010)
Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapi
Externí odkaz:
https://doaj.org/article/792ca1e4dfdf44a7b30a6e2470d70dad
Autor:
Thomas Durek, Jonas E. Jensen, Glenn F. King, Lachlan D. Rash, David J. Adams, Paul F. Alewood
Publikováno v:
Toxicon. 54:56-61
Acid sensing ion channels (ASICs) are pH-sensitive channels that are distributed in the central and peripheral nervous system and which are believed to play a key role in pain perception. APETx2, a 42-residue peptide toxin isolated from the sea anemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee350ed7ca01bed77fce333e457c185c
https://doi.org/10.1016/j.toxicon.2009.03.014
https://doi.org/10.1016/j.toxicon.2009.03.014
Autor:
Paul F. Alewood, Mehdi Mobli, K. Johan Rosengren, Raveendra Anangi, Carus H. Y. Lau, Jonas E. Jensen, Lachlan D. Rash, Glenn F. King, Andreas Brust, Ben Cristofori-Armstrong
Publikováno v:
Journal of medicinal chemistry. 57(21)
The sea anemone peptide APETx2 is a potent and selective blocker of acid-sensing ion channel 3 (ASIC3). APETx2 is analgesic in a variety of rodent pain models, but the lack of knowledge of its pharmacophore and binding site on ASIC3 has impeded devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3934a1cbd13cd426c947f361838e53
https://pubmed.ncbi.nlm.nih.gov/25337890
https://pubmed.ncbi.nlm.nih.gov/25337890
Autor:
Sebastian Senff, Sing Yan Er, Jonas E. Jensen, Glenn F. King, Lachlan D. Rash, Natalie J. Saez, Volker Herzig
Publikováno v:
Toxins
Toxins, Vol 2, Iss 12, Pp 2851-2871 (2010)
Toxins, Vol 2, Iss 12, Pp 2851-2871 (2010)
Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121c234c0220aa0338986f8dfddb8be7
https://pubmed.ncbi.nlm.nih.gov/22069579
https://pubmed.ncbi.nlm.nih.gov/22069579
Autor:
David J. Craik, Reena Halai, Jonas E. Jensen, David J. Adams, Richard J. Clark, Simon T. Nevin
Publikováno v:
The Journal of biological chemistry. 284(30)
Vc1.1 is a disulfide-rich peptide inhibitor of nicotinic acetylcholine receptors that has stimulated considerable interest in these receptors as potential therapeutic targets for the treatment of neuropathic pain. Here we present an extensive series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe9177306d660f812e8a48c0efea43f
https://pubmed.ncbi.nlm.nih.gov/19447885
https://pubmed.ncbi.nlm.nih.gov/19447885
Autor:
Brid P Callaghan, David J. Craik, David J. Adams, Jonas E. Jensen, Richard J. Clark, Simon T. Nevin
Publikováno v:
Angewandte Chemie. 122:6606-6606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2943c47c1b06ba072da3eb852350fd9
https://doi.org/10.1002/ange.201003933
https://doi.org/10.1002/ange.201003933
Autor:
Brid P Callaghan, Richard J. Clark, David J. Adams, Simon T. Nevin, Jonas E. Jensen, David J. Craik
Publikováno v:
Angewandte Chemie International Edition. 49:6460-6460
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::826cf7a7d6b2edf3e1b3046c0a9bd7f1
https://doi.org/10.1002/anie.201003933
https://doi.org/10.1002/anie.201003933