Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jonas Bystrom"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immune system protects from infections and cancer through complex cellular networks. For this purpose, immune cells require well-developed mechanisms of energy generation. However, the immune system itself can also cause diseases when defective r
Externí odkaz:
https://doaj.org/article/91b79d70d4554c339a7e4f4cad32d235
Autor:
Kawa Amin, Sulaf Mosa Issa, Kosar Mohammad Ali, Muaid Ismiel Aziz, Huner Mohamed Hama Amieen, Jonas Bystrom, Christer Janson
Publikováno v:
Clinical and Molecular Allergy, Vol 18, Iss 1, Pp 1-7 (2020)
Abstract Background The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients. Subjects and methods Blood samples were taken from 88 AR patients and 88 healthy controls (HC).
Externí odkaz:
https://doaj.org/article/c0c3f3fee52b4378ba1d9e1c3b666100
Autor:
Lauren A. Callender, Elizabeth C. Carroll, Conor Garrod-Ketchley, Johannes Schroth, Jonas Bystrom, Victoria Berryman, Melanie Pattrick, Desiree Campbell-Richards, Gillian A. Hood, Graham A. Hitman, Sarah Finer, Sian M. Henson
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8+ EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of senescent CD
Externí odkaz:
https://doaj.org/article/3d785a4ee8d34e03b1e989f0b39f8d14
Autor:
Xiaodong Zhuang, Federica Maione, Joseph Robinson, Michael Bentley, Baksho Kaul, Katharine Whitworth, Neeraj Jumbu, Elizabeth Jinks, Jonas Bystrom, Pietro Gabriele, Elisabetta Garibaldi, Elena Delmastro, Zsuzsanna Nagy, David Gilham, Enrico Giraudo, Roy Bicknell, Steven P. Lee
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on hematological cancers has yielded remarkable clinical responses, but with solid tumors, benefit has been more limited. This may reflect lack of suitable target
Externí odkaz:
https://doaj.org/article/078810883ce8406690b91f1dcd2ace3b
Publikováno v:
Viruses, Vol 5, Iss 3, Pp 777-791 (2013)
Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play a central role in the immune response during such infections. However,
Externí odkaz:
https://doaj.org/article/b37d89eaa78e4fe092ece9177cd91d0f
Autor:
Jonas Bystrom, Taher E. Taher, M. Sherwan Muhyaddin, Felix I. Clanchy, Pamela Mangat, Ali S. Jawad, Richard O. Williams, Rizgar A. Mageed
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subseq
Externí odkaz:
https://doaj.org/article/4051e58643034f90be5b87e551026a7c
Autor:
Jonas Bystrom, Scott J Thomson, Jörgen Johansson, Matthew L Edin, Darryl C Zeldin, Derek W Gilroy, Andrew M Smith, David Bishop-Bailey
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75107 (2013)
The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood. Here we investigated the role of CYP2J2 in bacte
Externí odkaz:
https://doaj.org/article/902d6d2647d543048745089c3cbd7f09
Autor:
Jonas Bystrom, Jessica A Wray, Mary C Sugden, Mark J Holness, Karen E Swales, Timothy D Warner, Matthew L Edin, Darryl C Zeldin, Derek W Gilroy, David Bishop-Bailey
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26591 (2011)
Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated responses is
Externí odkaz:
https://doaj.org/article/48caab00b23e41049a4c13ab8e5fb4af
Autor:
Jonas Bystrom, Amaia Carrascal-Miniño, George P Keeling, Truc Pham, Conor Garrod-Ketchley, Johannes Schroth, Rafael T. M. De Rosales, Samantha YA Terry, Sian M. Henson
The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means to assess cells’ functional deficitsin vivoare being made available such as total-body positron emission tomography (PET) and rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea6756cdaf0b25f41b3fe3d58ede24b
https://doi.org/10.1101/2023.02.04.23285413
https://doi.org/10.1101/2023.02.04.23285413
Autor:
Felix I.L. Clanchy, Ali S. M. Jawad, Rizgar A. Mageed, Jonas Bystrom, Richard O. Williams, Pamela Mangat, Mohammed M. Al-Bogami, Taher E. Taher
Publikováno v:
Rheumatology. 60:947-957
Objectives About half of RA patients treated with TNFα inhibitors either do not respond or lose their initial therapeutic response over time. The clinical response is measured by reduction in DAS28, which primarily reflects inflammation. However, ot