Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jonas Benzler"'
Autor:
Domenico Sergi, Fiona M. Campbell, Christine Grant, Amanda C. Morris, Eva-Maria Bachmair, Christiane Koch, Fiona H. McLean, Aifric Muller, Nigel Hoggard, Baukje de Roos, Begona Porteiro, Mark V. Boekschoten, Fiona C. McGillicuddy, Darcy Kahn, Phyllis Nicol, Jonas Benzler, Claus-Dieter Mayer, Janice E. Drew, Helen M. Roche, Michael Muller, Ruben Nogueiras, Carlos Dieguez, Alexander Tups, Lynda M. Williams
Publikováno v:
Genes & Nutrition, Vol 13, Iss 1, Pp 1-14 (2018)
Abstract Background Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these effects, a microarray-b
Externí odkaz:
https://doaj.org/article/f5bb12ec5e87442284aa5620612107c2
Publikováno v:
Comprehensive Physiology
The ability of the brain to directly control glucose levels in the blood independently of its effects on food intake and body weight has been known ever since 1854 when Claude Bernard, a French physiologist, discovered that lesioning the floor of the
Autor:
Mohammed Z. Rizwan, Cindy Hempp, Phil Heyward, Sigrid Stoehr, Alexander Tups, Jonas Benzler, Martin Benzler
Publikováno v:
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 189(3-4)
Saturated fatty acids are implicated in the development of metabolic diseases, including obesity and type 2 diabetes. There is evidence, however, that polyunsaturated fatty acids can counteract the pathogenic effects of saturated fatty acids. To gain
Publikováno v:
Endocrinology. 157:799-809
The WNT pathway was shown to play an important role in the adult central nervous system. We previously identified the WNT pathway as a novel integration site of the adipokine leptin in mediating its neuroendocrine control of metabolism in obese mice.
Autor:
Mohammed Z. Rizwan, Phil Heyward, Jonas Benzler, Cindy Hempp, Martin Benzler, Sigrid Stoehr, Alexander Tups
Saturated fatty acids are implicated in the development of metabolic diseases, including obesity and type 2 diabetes. There is evidence, however, that polyunsaturated fatty acids can counteract the pathogenic effects of saturated fatty acids. To gain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb88c8e05754e176f46906038c713928
https://doi.org/10.20944/preprints201807.0065.v1
https://doi.org/10.20944/preprints201807.0065.v1
Autor:
Eva-Maria Bachmair, Michael Müller, Fiona C. McGillicuddy, Christiane E. Koch, Baukje de Roos, Carlos Dieguez, Claus-Dieter Mayer, Domenico Sergi, Darcy E Kahn, Lynda M. Williams, Fiona Margaret Campbell, Rubén Nogueiras, Jonas Benzler, P. Nicol, Christine Grant, Alexander Tups, Fiona H. McLean, Helen M. Roche, Aifric Muller, Nigel Hoggard, Mark V. Boekschoten, Amanda C. Morris, Janice E. Drew, Begoña Porteiro
Publikováno v:
Genes & Nutrition, Vol 13, Iss 1, Pp 1-14 (2018)
Genes and Nutrition 13 (2018)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Genes and Nutrition, 13
Genes & Nutrition
Genes and Nutrition 13 (2018)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Genes and Nutrition, 13
Genes & Nutrition
Background Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these effects, a microarray-based tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03325a93aa125e6445c440ca806af94
http://hdl.handle.net/11392/2459706
http://hdl.handle.net/11392/2459706
Autor:
Dominik Pretz, Jonas Benzler, Carsten Culmsee, Alexander Tups, Rebecca Oelkrug, Christiane E. Koch, Karen Legler, Sigrid Stöhr, Goutham K. Ganjam, Lynda M. Williams
Publikováno v:
Diabetes. 64:2015-2027
Metabolic inflammation in the central nervous system might be causative for the development of overnutrition-induced metabolic syndrome and related disorders, such as obesity, leptin and insulin resistance, and type 2 diabetes. Here we investigated w
Autor:
David R. Grattan, Michael W. Schwartz, Goutham K. Ganjam, Christiane E. Koch, Peter R. Shepherd, Rebecca Ölkrug, Alexander Tups, Maria Kutschke, Sigrid Stöhr, Olaf Pinkenburg, Juliane Steger, Manon Krüger, Jonas Benzler
Publikováno v:
Biochemical Journal. 447:175-184
GSK3β (glycogen synthase kinase 3β) is a ubiquitous kinase that plays a key role in multiple intracellular signalling pathways, and increased GSK3β activity is implicated in disorders ranging from cancer to Alzheimer's disease. In the present stud
Autor:
Sarah Kathleen Haas Lockie, Zane B. Andrews, Jonas Benzler, Dana I Briggs, Helena C. Parkington, Qunli Wu, Romana Stark, Alexander Reichenbach, Harold A. Coleman, Alexander Tups, Andrew J. Hoy, Moyra B Lemus
Publikováno v:
Endocrinology. 155(7)
High-fat diet (HFD) feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/Agouti-related peptide neurons. In the current study, we investigated the time course over which this occurs and the mechanisms responsible for ghrelin resistance.
Autor:
Gregor Böttiger, Lynda M. Williams, David R. Grattan, Chrishanthi Lowe, Jonas Benzler, Christiane E. Koch, Alexander Tups, Alisa Boucsein, Karen Legler
Publikováno v:
Endocrinology. 155(5)
Adiponectin, an adipocyte-derived hormone, regulates glucose and lipid metabolism. It is also antiinflammatory. During obesity, adiponectin levels and sensitivity are reduced. Whereas the action of adiponectin in the periphery is well established the