Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jonas B Michaelis"'
Autor:
Iris Divé, Kevin Klann, Jonas B. Michaelis, Dennis Heinzen, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Although malignant gliomas frequently show aberrant activation of the mammalian target of rapamycin (mTOR), mTOR inhibitors have performed poorly in clinical trials. Besides regulating cell growth and translation, mTOR controls the initiatio
Externí odkaz:
https://doaj.org/article/b2d083bc71b34d12a417806d3a467b6b
Autor:
Zhixiao Wu, Lena A Berlemann, Verian Bader, Dominik A Sehr, Eva Dawin, Alberto Covallero, Jens Meschede, Lena Angersbach, Cathrin Showkat, Jonas B Michaelis, Christian Münch, Bettina Rieger, Dmitry Namgaladze, Maria Georgina Herrera, Fabienne C Fiesel, Wolfdieter Springer, Marta Mendes, Jennifer Stepien, Katalin Barkovits, Katrin Marcus, Albert Sickmann, Gunnar Dittmar, Karin B Busch, Dietmar Riedel, Marisa Brini, Jörg Tatzelt, Tito Cali, Konstanze F Winklhofer
Publikováno v:
The EMBO Journal
Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c63f16f190b57183474e40cd162e641
https://doi.org/10.15252/embj.2022112006
https://doi.org/10.15252/embj.2022112006
Autor:
Zhixiao Wu, Lena A. Berlemann, Verian Bader, Dominik Sehr, Eva Eilers, Alberto Covallero, Jens Meschede, Lena Angersbach, Cathrin Showkat, Jonas B. Michaelis, Christian Münch, Bettina Rieger, Dmitry Namgaladze, Maria Georgina Herrera, Fabienne C. Fiesel, Wolfdieter Springer, Marta Mendes, Jennifer Stepien, Katalin Barkovits, Katrin Marcus, Albert Sickmann, Gunnar Dittmar, Karin B. Busch, Dietmar Riedel, Marisa Brini, Jörg Tatzelt, Tito Cali, Konstanze F. Winklhofer
SUMMARYMitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff740e9a14981cdd6798b61dd0ae3c
https://hdl.handle.net/11577/3456968
https://hdl.handle.net/11577/3456968
Autor:
Ralf P. Brandes, Christian Münch, Yosif Manavski, Liliana Schaefer, Louise Tzung-Harn Hsieh, Renato V. Iozzo, Heiko Roedig, Madalina-Viviana Nastase, Ernst H. K. Stelzer, Jonas B. Michaelis, Chiara Poluzzi, André Bleich, Eva Miriam Buhl, Malgorzata Wygrecka, Ivan Dikic, Christian Brandts, Flávia Rezende, Jinyang Zeng-Brouwers, Josef Pfeilschifter, Peter Boor
Publikováno v:
Kidney International. 95:540-562
Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage recruitment via Toll-like receptors (TLR) 2 and 4. We have recently shown that biglycan signaling through TLR 2/4 and the CD14 co-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b12bf2e91dda29e8c1c1c297a263f5e
https://doi.org/10.1016/j.kint.2018.10.037
https://doi.org/10.1016/j.kint.2018.10.037
Publikováno v:
Molecular Cell
Summary Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochondrial protein import machinery cause human pathologies. However, a lack of suitable tools to measure protein uptake across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba229a984b99257a5ae60dde1063c9e8
http://europepmc.org/articles/PMC8791276
http://europepmc.org/articles/PMC8791276
Autor:
Simone Fulda, Christian Münch, Benedikt Linder, Nina Meyer, Svenja Zielke, Michel Mittelbronn, Jonas B. Michaelis, Donat Kögel, Heinz D. Osiewacz, Christian Behrends, Verena Warnsmann, Stefanie Rakel
Publikováno v:
Autophagy. 14:1693-1709
In most cases, macroautophagy/autophagy serves to alleviate cellular stress and acts in a pro-survival manner. However, the effects of autophagy are highly contextual, and autophagic cell death (ACD) is emerging as an alternative paradigm of (stress-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c358f38d9173e9b2c24bb7865e67e4f5
https://doi.org/10.1080/15548627.2018.1476812
https://doi.org/10.1080/15548627.2018.1476812
Assembling a Correctly Folded and Functional Heptahelical Membrane Protein by Protein Trans-splicing
Autor:
Jonas B. Michaelis, Alena Busche, Jennifer Kulhei, Carl Elias Eckert, Volker Dötsch, Clemens Glaubitz, Johanna Becker-Baldus, Michaela Mehler, Josef Wachtveitl
Publikováno v:
Journal of Biological Chemistry. 290:27712-27722
Protein trans-splicing using split inteins is well established as a useful tool for protein engineering. Here we show, for the first time, that this method can be applied to a membrane protein under native conditions. We provide compelling evidence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe81b460eddeb0557634e98ec795393
https://doi.org/10.1074/jbc.m115.681205
https://doi.org/10.1074/jbc.m115.681205
Autor:
Robert K. Ernst, Florian Wernig, Amir Houshang Bahrami, Gerhard Hummer, Claudius Stordeur, Jonas B. Michaelis, Andreas M. Ernst, Kristina Puth, Roberto Covino, Stephanie Ballweg
Publikováno v:
ResearcherID
Maintaining a fluid bilayer is essential for cell signaling and survival. Lipid saturation is a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to guarantee organelle function and identity. A dedicated eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8575417c442abaab050fd2b88129e9a
https://pubmed.ncbi.nlm.nih.gov/27320200
https://pubmed.ncbi.nlm.nih.gov/27320200